PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27940557-5	2017	These findings collectively demonstrate a hitherto unknown role of MDC1 And-1 CtIP axis that regulates CtIP-mediated DNA end resection and cellular response to DSBs.	dsbs	160-164	mediator of DNA damage checkpoint 1	Homo sapiens	67-71	
22942284-3	2012	A key early event in the DDR is the phosphorylation of histone H2AX around DSBs, which forms a binding site for the tandem BRCA1 C-terminal (tBRCT) domain of MDC1.	dsbs	75-79	mediator of DNA damage checkpoint 1	Homo sapiens	158-162	
26845027-2	2016	The Mediator of DNA damage Checkpoint protein 1 (MDC1) is essential for spreading of the DDR signaling on chromatin surrounding Double Strand Breaks (DSBs) by acting as a scaffold for PI3K kinases and for ubiquitin ligases.	dsbs	150-154	mediator of DNA damage checkpoint 1	Homo sapiens	4-47	
26845027-2	2016	The Mediator of DNA damage Checkpoint protein 1 (MDC1) is essential for spreading of the DDR signaling on chromatin surrounding Double Strand Breaks (DSBs) by acting as a scaffold for PI3K kinases and for ubiquitin ligases.	dsbs	150-154	mediator of DNA damage checkpoint 1	Homo sapiens	49-53	
19450528-5	2009	MDC1 is essential for gamma-H2AX formation at high densities near DSBs, but not for generation of gamma-H2AX over distal sequences.	dsbs	66-70	mediator of DNA damage checkpoint 1	Homo sapiens	0-4	
21676867-6	2011	As a functional consequence, we show that the H2AX K120R mutant abolishes H2AX monoubiquitination, impairs the recruitment of p-ATM (Ser(1981)) to DSBs, and thereby reduces the formation of gamma-H2AX and the recruitment of MDC1 to DNA damage sites.	dsbs	147-151	mediator of DNA damage checkpoint 1	Homo sapiens	224-228	
21293379-6	2011	Furthermore, we found that the recruitment of MMSET to DSBs requires the gammaH2AX-MDC1 pathway; specifically, the interaction between the MDC1 BRCT domain and phosphorylated Ser 102 of MMSET.	dsbs	55-59	mediator of DNA damage checkpoint 1	Homo sapiens	83-87	
21293379-6	2011	Furthermore, we found that the recruitment of MMSET to DSBs requires the gammaH2AX-MDC1 pathway; specifically, the interaction between the MDC1 BRCT domain and phosphorylated Ser 102 of MMSET.	dsbs	55-59	mediator of DNA damage checkpoint 1	Homo sapiens	139-143	
21293379-7	2011	Thus, we propose that a pathway involving gammaH2AX-MDC1-MMSET regulates the induction of H4K20 methylation on histones around DSBs, which, in turn, facilitates 53BP1 recruitment.	dsbs	127-131	mediator of DNA damage checkpoint 1	Homo sapiens	52-56	
20026654-5	2009	Autophosphorylated ATM interacts with MDC1 and the latter is required for the prolonged association of ATM to DSBs.	dsbs	110-114	mediator of DNA damage checkpoint 1	Homo sapiens	38-42	
16009723-6	2005	Furthermore, short interfering RNA-mediated ablation of Mdc1/NFBD1 drastically impaired 53BP1 redistribution to DSBs and triggered premature dissociation of 53BP1 from these regions.	dsbs	112-116	mediator of DNA damage checkpoint 1	Homo sapiens	56-60	
18757370-9	2008	Consistent with this observation, chromatin immunoprecipitation experiments reveal increased MDC1 protein at site-specific DSBs.	dsbs	123-127	mediator of DNA damage checkpoint 1	Homo sapiens	93-97	
16009723-6	2005	Furthermore, short interfering RNA-mediated ablation of Mdc1/NFBD1 drastically impaired 53BP1 redistribution to DSBs and triggered premature dissociation of 53BP1 from these regions.	dsbs	112-116	mediator of DNA damage checkpoint 1	Homo sapiens	61-66	
15201865-2	2004	Here, we show that in live human cells, the transient interaction of Nbs1 with DSBs and its phosphorylation by ATM are Mdc1-independent.	dsbs	79-83	mediator of DNA damage checkpoint 1	Homo sapiens	119-123