PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31353207-5	2019	Either excess or insufficient C1QBP impedes the recruitment of MRE11 to DSBs and impairs the DNA damage response.	dsbs	72-76	MRE11 homolog, double strand break repair nuclease	Homo sapiens	63-68	
33918759-9	2021	Co-immunoprecipitation studies revealed interactions between RAGE and pATM and MRE11 during DNA-DSBs.	dsbs	96-100	MRE11 homolog, double strand break repair nuclease	Homo sapiens	79-84	
33087279-6	2020	Recent studies have identified a number of nucleases, especially the MRE11 nuclease, as key factors performing the removal of blocking chemical adducts to restore clean ligatable DSBs for subsequent NHEJ.	dsbs	179-183	MRE11 homolog, double strand break repair nuclease	Homo sapiens	69-74	
32313254-4	2020	The principle of this method is to track the precise recruitment of MRE11 to DSBs by chromatin immunoprecipitation followed by next-generation sequencing.	dsbs	77-81	MRE11 homolog, double strand break repair nuclease	Homo sapiens	68-73	
30510002-7	2018	We suggest that persistent Sae2 binding at DSBs in the mre11-nd mutant counteracts the inhibitory effects of Rad9 and Rad53 on Exo1 and Dna2-Sgs1-mediated resection, accounting for the different phenotypes conferred by mre11-nd and sae2Delta mutations.	dsbs	43-47	MRE11 homolog, double strand break repair nuclease	Homo sapiens	55-60	
31231660-2	2019	The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex that has structural and catalytic functions.	dsbs	25-29	MRE11 homolog, double strand break repair nuclease	Homo sapiens	75-80	
30168750-4	2019	The H2AX and MRE11 proteins generated following DSBs formation and pro-inflammatory cytokines (CKs) secreted after irradiation are relevant candidates to monitor the cellular responses induced by CBCT.	dsbs	48-52	MRE11 homolog, double strand break repair nuclease	Homo sapiens	13-18	
29420790-4	2018	By assessing the impact of these mutations at the cellular and structural levels, we found that all the mre11 alleles that restore sae2Delta resistance to both camptothecin and phleomycin affect the Mre11 N-terminus and suppress the resection defect of sae2Delta cells by lowering MRX and Tel1 association to DSBs.	dsbs	309-313	MRE11 homolog, double strand break repair nuclease	Homo sapiens	104-109	
26743002-2	2016	The yeast and mammalian Mre11-Rad50-Xrs2/Nbs1 (MRX/N)-Sae2/Ctp1 complex catalyzes the resection of DSBs induced by secondary structures, chemical adducts or covalently-attached proteins.	dsbs	99-103	MRE11 homolog, double strand break repair nuclease	Homo sapiens	24-29	
25486192-8	2014	Resection of complex DSBs is driven by meiotic recombination 11 homolog A (MRE11), CTBP-interacting protein (CtIP), and exonuclease 1 (EXO1) but seems not controlled by the Ku heterodimer or by phosphorylation of H2AX.	dsbs	21-25	MRE11 homolog, double strand break repair nuclease	Homo sapiens	39-73	
25486192-8	2014	Resection of complex DSBs is driven by meiotic recombination 11 homolog A (MRE11), CTBP-interacting protein (CtIP), and exonuclease 1 (EXO1) but seems not controlled by the Ku heterodimer or by phosphorylation of H2AX.	dsbs	21-25	MRE11 homolog, double strand break repair nuclease	Homo sapiens	75-80	
23912341-2	2013	The MRE11/RAD50/NBS1 (MRN) complex binds DSBs and initiates damage-induced signaling cascades via activation of the ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia- and rad3-related (ATR) kinases.	dsbs	41-45	MRE11 homolog, double strand break repair nuclease	Homo sapiens	4-9	
24297933-6	2013	Rsk can phosphorylate the Mre11 protein directly at S676 both in vitro and in intact cells and thereby can inhibit the binding of Mre11 to DNA with DSBs.	dsbs	148-152	MRE11 homolog, double strand break repair nuclease	Homo sapiens	26-31	
24297933-6	2013	Rsk can phosphorylate the Mre11 protein directly at S676 both in vitro and in intact cells and thereby can inhibit the binding of Mre11 to DNA with DSBs.	dsbs	148-152	MRE11 homolog, double strand break repair nuclease	Homo sapiens	130-135	
22131123-1	2012	Nibrin, product of the NBN gene, together with MRE11 and RAD50 is involved in DNA double-strand breaks (DSBs) sensing and repair, induction of apoptosis and cell cycle control.	dsbs	104-108	MRE11 homolog, double strand break repair nuclease	Homo sapiens	47-52	
23770241-5	2013	The Ku mutants fail to regulate Exo1 activity, and bypass the requirement for Mre11 nuclease activity in the repair of camptothecin-induced single-ended DSBs.	dsbs	153-157	MRE11 homolog, double strand break repair nuclease	Homo sapiens	78-83	
20064462-5	2009	We find that CtIP translocates to DSBs, a process dependent on the DSB sensor complex Mre11-Rad50-NBS1, the kinase activity of ATM, and a direct DNA-binding motif in CtIP, and then promotes DSB resection.	dsbs	34-38	MRE11 homolog, double strand break repair nuclease	Homo sapiens	86-91	
21150274-2	2010	In response to DSBs, ATM dimers dissociate into active monomers in a process promoted by the Mre11-Rad50-Nbs1 (MRN) complex.	dsbs	15-19	MRE11 homolog, double strand break repair nuclease	Homo sapiens	93-98	
21290468-2	2010	The Mre11 complex (composed of Mre11, Rad50, and Nbs1) is involved in DSB repair and forms foci at sites of radiation-induced DSBs.	dsbs	126-130	MRE11 homolog, double strand break repair nuclease	Homo sapiens	4-9	
21290468-2	2010	The Mre11 complex (composed of Mre11, Rad50, and Nbs1) is involved in DSB repair and forms foci at sites of radiation-induced DSBs.	dsbs	126-130	MRE11 homolog, double strand break repair nuclease	Homo sapiens	31-36	
20081839-10	2010	53BP1 amplifies Mre11-NBS1 accumulation at late-repairing DSBs, concentrating active ATM and leading to robust, localized pKAP-1.	dsbs	58-62	MRE11 homolog, double strand break repair nuclease	Homo sapiens	16-21	
11832209-5	2002	Failure of the mre11, rad50, xrs2, and sae2 mutants to process the hairpins blocks recombinational repair of the DSBs and leads to generation of chromosome inverted duplications.	dsbs	113-117	MRE11 homolog, double strand break repair nuclease	Homo sapiens	15-20	
14657032-3	2003	It is unclear which proteins recognize DSBs and activate these pathways, but the Mre11/Rad50/NBS1 complex has been suggested to act as a damage sensor.	dsbs	39-43	MRE11 homolog, double strand break repair nuclease	Homo sapiens	81-86	
14657032-6	2003	Using these viral proteins, we show that the Mre11 complex is required for both ATM activation and the ATM-dependent G(2)/M checkpoint in response to DSBs.	dsbs	150-154	MRE11 homolog, double strand break repair nuclease	Homo sapiens	45-50	
14532133-4	2003	The MRN complex, whose core contains the Mre11, Rad50 and Nbs1 proteins, is involved in the initial processing of DSBs.	dsbs	114-118	MRE11 homolog, double strand break repair nuclease	Homo sapiens	41-46	
18632984-4	2008	The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci.	dsbs	26-30	MRE11 homolog, double strand break repair nuclease	Homo sapiens	83-88	
16879433-1	2006	Together with the Tel1 PI3 kinase, the Mre11/Rad50/Xrs2 (MRX) complex is involved in checkpoint activation in response to double-strand breaks (DSBs), a function also conserved in human cells by Mre11/Rad50/Nbs1 acting with ATM.	dsbs	144-148	MRE11 homolog, double strand break repair nuclease	Homo sapiens	39-44	
16879433-1	2006	Together with the Tel1 PI3 kinase, the Mre11/Rad50/Xrs2 (MRX) complex is involved in checkpoint activation in response to double-strand breaks (DSBs), a function also conserved in human cells by Mre11/Rad50/Nbs1 acting with ATM.	dsbs	144-148	MRE11 homolog, double strand break repair nuclease	Homo sapiens	195-200	
15908798-2	2005	Recent evidence suggests that the DNA repair complex containing Mre11, Rad50 and Nbs1 (MRN) is important for the activation of ATM by DSBs in cells.	dsbs	134-138	MRE11 homolog, double strand break repair nuclease	Homo sapiens	64-69	
11533665-7	2001	Thus, the integrity of the Mre11/Rad50/Xrs2 complex is specifically required for checkpoint activation after the formation of DSBs.	dsbs	126-130	MRE11 homolog, double strand break repair nuclease	Homo sapiens	27-32	
33789097-3	2021	Mre11 endonuclease activity is stimulated by Sae2, whose lack increases MRX persistence at DSBs and checkpoint activation.	dsbs	91-95	MRE11 homolog, double strand break repair nuclease	Homo sapiens	0-5	
11418077-6	2001	The nuclear protein MRE11 is a component of a multi-protein complex involved in nonhomologous end joining (NHEJ) of radiation-induced DSBs.	dsbs	134-138	MRE11 homolog, double strand break repair nuclease	Homo sapiens	20-25	
35076389-3	2022	In response to DSBs, ATM is activated by the MRN (Mre11-Rad50-Nbs1) protein complex through a poorly-understood process that also requires double-stranded DNA.	dsbs	15-19	MRE11 homolog, double strand break repair nuclease	Homo sapiens	50-55