PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33966123-5 2021 This enhanced meiotic mutagenicity is shown to depend on the presence of SPO11, the gene responsible for meiotic DSBs. dsbs 113-117 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 73-78 15514052-10 2004 Our results demonstrate that although the Spo11-induced DSBs obviously promote synapsis in yeast, the presence of Spo11 is not an absolute requirement for synapsis. dsbs 56-60 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 42-47 11157765-8 2001 Thus, our data show that initiation of meiotic recombination by SPO11- induced DSBs is a mechanism conserved in plants. dsbs 79-83 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 64-69 34108687-2 2021 Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots3,4, yet how Spo11 engages with its DNA substrate to catalyse DNA cleavage is poorly understood. dsbs 6-10 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 0-5 34108687-2 2021 Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots3,4, yet how Spo11 engages with its DNA substrate to catalyse DNA cleavage is poorly understood. dsbs 6-10 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 90-95 32842152-2 2020 In Arabidopsis, in contrast to yeast and mammals, DSBs are presumably catalyzed by two distinct SPO11 proteins, AtSPO11-1 and AtSPO11-2, together with the M-TOPOVIB. dsbs 50-54 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 96-101 33842461-4 2021 In budding yeast, Spo11-mediated meiotic DSBs activate Mec1/Tel1, but not Rad53; however, the mechanism underlying the insensitivity of Rad53 to meiotic DSBs remains largely unknown. dsbs 153-157 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 18-23 33842461-4 2021 In budding yeast, Spo11-mediated meiotic DSBs activate Mec1/Tel1, but not Rad53; however, the mechanism underlying the insensitivity of Rad53 to meiotic DSBs remains largely unknown. dsbs 41-45 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 18-23 32652040-3 2020 During meiosis, Spo11-induced DSB onset and repair lasts up to 5 h. We report that the NH2-terminal domain (NTD; residues 1-66) of Rad51 has dual functions for repairing DSBs during vegetative growth and meiosis. dsbs 170-174 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 16-21 23775120-6 2013 gammaH2A phosphorylation is Red1 independent and occurs prior to Spo11-induced DSBs. dsbs 79-83 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 65-70 23313097-2 2013 These DSBs, catalyzed by the evolutionary conserved Spo11 protein, are highly regulated. dsbs 6-10 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 52-57 21146476-2 2011 Mostly these DSBs are made by Spo11, which covalently binds to the DSB ends. dsbs 13-17 DNA topoisomerase (ATP-hydrolyzing) Saccharomyces cerevisiae S288C 30-35