PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33966123-5	2021	This enhanced meiotic mutagenicity is shown to depend on the presence of SPO11, the gene responsible for meiotic DSBs.	dsbs	113-117	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	73-78	
15514052-10	2004	Our results demonstrate that although the Spo11-induced DSBs obviously promote synapsis in yeast, the presence of Spo11 is not an absolute requirement for synapsis.	dsbs	56-60	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	42-47	
11157765-8	2001	Thus, our data show that initiation of meiotic recombination by SPO11- induced DSBs is a mechanism conserved in plants.	dsbs	79-83	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	64-69	
34108687-2	2021	Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots3,4, yet how Spo11 engages with its DNA substrate to catalyse DNA cleavage is poorly understood.	dsbs	6-10	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	0-5	
34108687-2	2021	Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots3,4, yet how Spo11 engages with its DNA substrate to catalyse DNA cleavage is poorly understood.	dsbs	6-10	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	90-95	
32842152-2	2020	In Arabidopsis, in contrast to yeast and mammals, DSBs are presumably catalyzed by two distinct SPO11 proteins, AtSPO11-1 and AtSPO11-2, together with the M-TOPOVIB.	dsbs	50-54	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	96-101	
33842461-4	2021	In budding yeast, Spo11-mediated meiotic DSBs activate Mec1/Tel1, but not Rad53; however, the mechanism underlying the insensitivity of Rad53 to meiotic DSBs remains largely unknown.	dsbs	153-157	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	18-23	
33842461-4	2021	In budding yeast, Spo11-mediated meiotic DSBs activate Mec1/Tel1, but not Rad53; however, the mechanism underlying the insensitivity of Rad53 to meiotic DSBs remains largely unknown.	dsbs	41-45	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	18-23	
32652040-3	2020	During meiosis, Spo11-induced DSB onset and repair lasts up to 5 h. We report that the NH2-terminal domain (NTD; residues 1-66) of Rad51 has dual functions for repairing DSBs during vegetative growth and meiosis.	dsbs	170-174	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	16-21	
23775120-6	2013	gammaH2A phosphorylation is Red1 independent and occurs prior to Spo11-induced DSBs.	dsbs	79-83	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	65-70	
23313097-2	2013	These DSBs, catalyzed by the evolutionary conserved Spo11 protein, are highly regulated.	dsbs	6-10	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	52-57	
21146476-2	2011	Mostly these DSBs are made by Spo11, which covalently binds to the DSB ends.	dsbs	13-17	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	30-35