PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16461339-5	2006	Whereas ATM signals DSBs arising from ionizing radiation (IR) through a Chk2-dependent pathway, ATR is activated in a variety of replication-linked DSBs and leads to activation of the checkpoints in a Chk1 kinase-dependent manner.	dsbs	148-152	checkpoint kinase 1	Homo sapiens	201-205	
24204313-3	2013	Here, we show that MUS81-induced DSBs are specifically triggered by CHK1 inhibition in a manner that is unrelated to the loss of RAD51, and does not involve formation of a RAD51 substrate.	dsbs	33-37	checkpoint kinase 1	Homo sapiens	68-72	
20421415-4	2010	We show that ATM-dependent resection at a subset of DSBs leads to ATR-dependent Chk1 activation.	dsbs	52-56	checkpoint kinase 1	Homo sapiens	80-84	
21098122-8	2011	A Tel1-to-Chk1 checkpoint pathway acting at unresected DSBs provides a mechanism for coupling Chk1 activation to the initial detection of DSBs and suggests that ATM may activate Chk1 by both direct and indirect mechanisms in mammalian cells.	dsbs	55-59	checkpoint kinase 1	Homo sapiens	10-14	
21098122-8	2011	A Tel1-to-Chk1 checkpoint pathway acting at unresected DSBs provides a mechanism for coupling Chk1 activation to the initial detection of DSBs and suggests that ATM may activate Chk1 by both direct and indirect mechanisms in mammalian cells.	dsbs	55-59	checkpoint kinase 1	Homo sapiens	94-98	
21098122-8	2011	A Tel1-to-Chk1 checkpoint pathway acting at unresected DSBs provides a mechanism for coupling Chk1 activation to the initial detection of DSBs and suggests that ATM may activate Chk1 by both direct and indirect mechanisms in mammalian cells.	dsbs	55-59	checkpoint kinase 1	Homo sapiens	94-98	
21034966-5	2010	In response to DSBs, ATM is required both for ATR-Chk1 activation and to initiate DNA repair via homologous recombination (HRR) by promoting formation of single-stranded DNA at sites of damage through nucleolytic resection.	dsbs	15-19	checkpoint kinase 1	Homo sapiens	50-54	
16618811-6	2006	These are further subclassified to proteins that connect DSBs with the rest of the nucleus (Chk1 and -2), that assemble at unprocessed DSBs (DNA-PK/Ku70), and that exist on chromatin as preassembled complexes but become locally modified after DNA damage (Smc1/Smc3).	dsbs	57-61	checkpoint kinase 1	Homo sapiens	92-103	
11533665-3	2001	Here we show that this complex is required for phosphorylation and activation of the Rad53 and Chk1 checkpoint kinases specifically in response to DSBs.	dsbs	147-151	checkpoint kinase 1	Homo sapiens	95-99