PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27348077-7	2016	However, our findings suggest that when challenged by DSBs, BRCA1- and 53BP1-deficient cells may become hypersensitive to, and be eliminated by, RAD52 inhibition.	dsbs	54-58	BRCA1 DNA repair associated	Homo sapiens	60-65	
34385259-5	2021	In the second S phase, BRCA1/2-deficient cells are unable to suppress origin firing through ATR, resulting in continuous DNA synthesis and more DSBs.	dsbs	144-148	BRCA1 DNA repair associated	Homo sapiens	23-30	
34385259-7	2021	Thus, PARPi induces DSBs progressively through trans cell cycle ssDNA gaps, and BRCA1/2-deficient cells fail to slow down and repair DSBs over multiple cell cycles, explaining the unique efficacy of PARPi in BRCA1/2-deficient cells.	dsbs	20-24	BRCA1 DNA repair associated	Homo sapiens	208-215	
28406400-2	2017	DSBs elicit a cascade of events controlled by the ubiquitin ligase RNF168, which promotes the accumulation of repair factors such as 53BP1 and BRCA1 on the chromatin flanking the break site.	dsbs	0-4	BRCA1 DNA repair associated	Homo sapiens	143-148	
20876283-6	2010	Further, the destabilization of nucleosomes by p400 is required for the RNF8-dependent ubiquitination of chromatin, and for the subsequent recruitment of brca1 and 53BP1 to DSBs.	dsbs	173-177	BRCA1 DNA repair associated	Homo sapiens	154-159	
24464432-2	2014	In response to DSBs, the ATM kinase is activated and subsequently phosphorylates numerous downstream substrates, including p53, Chk2, BRCA1, and KAP1, which affect processes such as cell cycle progression and DNA repair.	dsbs	15-19	BRCA1 DNA repair associated	Homo sapiens	134-139	
20921134-4	2010	In the absence of BMI1, several proteins dependent on ubiquitin signaling, including 53BP1, BRCA1, and RAP80, are impaired in recruitment to DSBs.	dsbs	141-145	BRCA1 DNA repair associated	Homo sapiens	92-97	
22942284-3	2012	A key early event in the DDR is the phosphorylation of histone H2AX around DSBs, which forms a binding site for the tandem BRCA1 C-terminal (tBRCT) domain of MDC1.	dsbs	75-79	BRCA1 DNA repair associated	Homo sapiens	123-128	
20725033-3	2010	DSBs elicit a signalling cascade that modifies the chromatin surrounding the break, first by ATM-dependent phosphorylation and then by RNF8-, RNF168- and BRCA1-dependent regulatory ubiquitination.	dsbs	0-4	BRCA1 DNA repair associated	Homo sapiens	154-159	
20423312-6	2010	Here, we provide an overview about DSBs damage response, focusing on the role of the DSBs repair mechanisms, of chromatin modifications, and of the cancer susceptibility gene BRCA1 which plays a multifunctional role in controlling genome integrity.	dsbs	35-39	BRCA1 DNA repair associated	Homo sapiens	175-180