PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34337561-1 2021 Hereditary sensory neuropathy type 1 (HSN1) is caused by mutations in the SPTLC1 or SPTLC2 sub-units of the enzyme serine palmitoyltransferase, resulting in the production of toxic 1-deoxysphingolipid bases (DSBs). dsbs 208-212 serine palmitoyltransferase long chain base subunit 1 Homo sapiens 38-42 34337561-1 2021 Hereditary sensory neuropathy type 1 (HSN1) is caused by mutations in the SPTLC1 or SPTLC2 sub-units of the enzyme serine palmitoyltransferase, resulting in the production of toxic 1-deoxysphingolipid bases (DSBs). dsbs 208-212 serine palmitoyltransferase long chain base subunit 1 Homo sapiens 74-80 20097765-3 2010 Here we show that the HSAN1 mutations induce a shift in the substrate specificity of SPT, which leads to the formation of the two atypical deoxy-sphingoid bases (DSBs) 1-deoxy-sphinganine and 1-deoxymethyl-sphinganine. dsbs 162-166 serine palmitoyltransferase long chain base subunit 1 Homo sapiens 22-27