PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12477263-6 2002 Epo (i) decreases glutamate toxicity, (ii) induces the generation of neuronal anti-apoptotic factors, (iii) reduces inflammation, (iv) decreases nitric oxide-mediated injury, and (v) has direct antioxidant effects. Glutamic Acid 18-27 erythropoietin Homo sapiens 0-3 16595066-4 2005 The neuroprotective effects of EPO have various complementary actions including antagonism of the effects of glutamate, increased expression of antioxidant enzymes, changes in production of neurotransmitters and induction of neuroglobin. Glutamic Acid 109-118 erythropoietin Homo sapiens 31-34 15979589-0 2005 Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells. Glutamic Acid 45-54 erythropoietin Homo sapiens 27-41 15979589-2 2005 Because retinal ganglion cell (RGC) death is a common cause of reduced visual function in several ocular diseases, we explored whether Epo might potentially be beneficial in protecting RGCs from glutamate and nitric oxide (NO)-induced cytotoxicity, using isolated RGCs by a two-step panning method. Glutamic Acid 195-204 erythropoietin Homo sapiens 135-138 15979589-8 2005 Both Epo and BDNF significantly reduced RGC death induced by glutamate and NO. Glutamic Acid 61-70 erythropoietin Homo sapiens 5-8 15727557-8 2005 In vitro EPO protects against glutamate-induced cell death in a dose-dependent way. Glutamic Acid 30-39 erythropoietin Homo sapiens 9-12 15322761-6 2004 Epo prevents neuronal cells from hypoxia-induced and glutamate-induced cell death. Glutamic Acid 53-62 erythropoietin Homo sapiens 0-3 14582001-6 2003 The mechanisms of EPO-induced neuroprotection include prevention of glutamate-induced toxicity, inhibition of apoptosis, anti-inflammatory effects, antioxidant effects, and stimulation of angiogenesis. Glutamic Acid 68-77 erythropoietin Homo sapiens 18-21 16440497-4 2005 In addition erythropoietin is protective against several mechanisms of neuronal injury: it alleviates the outcome of hypoxia and glutamate toxicity and has antiapoptotic effects. Glutamic Acid 129-138 erythropoietin Homo sapiens 12-26 12324729-1 2002 OBJECTIVE: Recent studies have shown that erythropoietin protects neurons from glutamate toxicity and ischemia. Glutamic Acid 79-88 erythropoietin Homo sapiens 42-56 12324729-6 2002 The erythropoietin group had higher vascular resistance and mean arterial pressure values, lower intracerebral concentrations of glutamate and glycerol, higher brain tissue oxygen tension, and lower apoptotic index. Glutamic Acid 129-138 erythropoietin Homo sapiens 4-18 1761028-8 1991 Mutagenesis of wild-type human erythropoietin cDNA was used to produce a series of mutant proteins with sequential deletion of three adjacent amino acids and insertion of the sequence Glu-Phe across the two domains. Glutamic Acid 184-187 erythropoietin Homo sapiens 31-45 11504731-0 2001 Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia. Glutamic Acid 58-67 erythropoietin Homo sapiens 0-14 11504731-1 2001 Erythropoietin (EPO) reduced Ca(2+)-induced glutamate (Glu) release from cultured cerebellar granule neurons. Glutamic Acid 44-53 erythropoietin Homo sapiens 0-14 11504731-1 2001 Erythropoietin (EPO) reduced Ca(2+)-induced glutamate (Glu) release from cultured cerebellar granule neurons. Glutamic Acid 44-53 erythropoietin Homo sapiens 16-19 11504731-1 2001 Erythropoietin (EPO) reduced Ca(2+)-induced glutamate (Glu) release from cultured cerebellar granule neurons. Glutamic Acid 55-58 erythropoietin Homo sapiens 0-14 11504731-1 2001 Erythropoietin (EPO) reduced Ca(2+)-induced glutamate (Glu) release from cultured cerebellar granule neurons. Glutamic Acid 55-58 erythropoietin Homo sapiens 16-19 11504731-4 2001 Furthermore, genistein, but not genistin, antagonized both the phosphorylation of JAK2 and the suppression of Glu release induced by EPO and EMP1. Glutamic Acid 110-113 erythropoietin Homo sapiens 133-136 10987435-2 2000 Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10-50 microM) affinity for EBP; "dimerization" of the most potent analogues by coupling with linear diamines led to EPO competitors having 1-2 microM binding affinities. Glutamic Acid 38-51 erythropoietin Homo sapiens 200-203 10936493-1 2000 Erythropoietin prevents in vitro glutamate-induced neuronal death and could play a role in the central nervous system. Glutamic Acid 33-42 erythropoietin Homo sapiens 0-14 28629519-8 2017 Preclinical research demonstrates erythropoietin"s ability to suppress glutamate excitotoxicity and intracellular Ca2+ overload, dampen oxidative stress and inflammation, interrupt the apoptotic cascade, and preserve BBB integrity. Glutamic Acid 71-80 erythropoietin Homo sapiens 34-48 25255196-3 2014 Here, we achieved selective delivery of recombinant human erythropoietin (rHuEPO) to bone marrow, via its encapsulation in liposomes with l-glutamic acid, N-(3-carboxy-1-oxopropyl)-, 1,5-dihexadecyl ester (SA) (liposome-EPO). Glutamic Acid 138-153 erythropoietin Homo sapiens 58-72 25753141-1 2015 A method based on CZE for the determination of glutamic acid, glycine, and alanine in a biopharmaceutical formulation containing recombinant human erythropoietin was developed. Glutamic Acid 47-60 erythropoietin Homo sapiens 147-161 25259652-5 2015 Recombinant erythropoietin treatment increased mitochondrial O2 flux during ADP stimulated state 3 respiration in the presence of complex I and II substrates (malate, glutamate, pyruvate, succinate) with additional electron input from beta-oxidation (octanoylcarnitine) (from 60 +- 13 to 87 +- 24 pmol s(-1) mg(-1) P < 0.01). Glutamic Acid 167-176 erythropoietin Homo sapiens 12-26 25255196-3 2014 Here, we achieved selective delivery of recombinant human erythropoietin (rHuEPO) to bone marrow, via its encapsulation in liposomes with l-glutamic acid, N-(3-carboxy-1-oxopropyl)-, 1,5-dihexadecyl ester (SA) (liposome-EPO). Glutamic Acid 138-153 erythropoietin Homo sapiens 77-80 19609278-6 2009 All their functional deficits observed under hypoxia, Glu exposure and APPsw-PC12 cocultivation were reversed by the application of EPO, which increased the expression of Wnt3a. Glutamic Acid 54-57 erythropoietin Homo sapiens 132-135 25958529-0 2014 Protective effects of poly(lactic-co-glycolic acid) nanoparticles loaded with erythropoietin stabilized by sodium cholate against glutamate-induced neurotoxicity. Glutamic Acid 130-139 erythropoietin Homo sapiens 78-92 17624659-4 2007 As erythropoietin having direct and indirect effect on nerve cells, enhances antioxidotic enzyme production, antagonizes glutamate"s cytotoxic action, metabolizes free radicals, normalizes cerebral blood flow, affects neurotransmitters release and stimulates neoangiogenesis. Glutamic Acid 121-130 erythropoietin Homo sapiens 3-17