PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10736381-2 2000 However, only a single human study has reported that an oral load of glutamic acid induced the secretion of prolactin and probably adrenocorticotropic hormone (ACTH) (but not other pituitary hormones). Glutamic Acid 69-82 proopiomelanocortin Homo sapiens 131-158 16388118-7 2005 Changes in ACTH and cortisol release may be of importance for mood stabilizing effects of antiepileptic drugs modulating glutamate release, such as lamotrigine. Glutamic Acid 121-130 proopiomelanocortin Homo sapiens 11-15 16388118-9 2005 Little information is available on ACTH release in response to glutamate-modulating drugs used in the treatment of schizophrenia and Alzheimer disease. Glutamic Acid 63-72 proopiomelanocortin Homo sapiens 35-39 15749695-9 2005 The glutamate mutants displayed an altered cleavage profile for the peptide beta-endorphin. Glutamic Acid 4-13 proopiomelanocortin Homo sapiens 76-90 10959000-6 2000 We conclude that the biologic activity of alpha-MSH, as observed through the levels of cAMP, declines when the length of its polypeptide chain is shortened, and that the presence of glutamic acid in the molecule, as well as the core sequence, are of importance for fragments" activity. Glutamic Acid 182-195 proopiomelanocortin Homo sapiens 42-51 7641799-1 1995 The small cell lung carcinoma cell line U-1690 bound beta-endorphin via nonopioid binding sites also recognized by the C-terminal part of this opioid peptide Lys-Lys-Gly-Glu, but not by opiate alkaloids such as naloxone and morphine or other opioid peptides. Glutamic Acid 170-173 proopiomelanocortin Homo sapiens 53-67 10374630-0 1998 Enhancing effects of beta-endorphin on glutamate neurotoxicity. Glutamic Acid 39-48 proopiomelanocortin Homo sapiens 21-35 9427354-5 1997 The observations provide morphological evidence for the view that glutamate, which appears to be a major excitatory neurotransmitter in the hypothalamus, may directly stimulate GHRH and beta-endorphin neurones of the medial hypothalamus. Glutamic Acid 66-75 proopiomelanocortin Homo sapiens 186-200 8899819-2 1996 Ac-Ser.Tyr-Ser-Nle4-Glu- His-DPhe7-Arg-Trp-Gly-Lys-Pro-Val-NH2(NDP-MSH), led to the discovery of tripeptide agonists possessing prolonged bioactivity in the frog skin assay. Glutamic Acid 20-23 proopiomelanocortin Homo sapiens 67-70 11938958-0 1998 [Effects of beta-endorphin on glutamate neurotoxicity]. Glutamic Acid 30-39 proopiomelanocortin Homo sapiens 12-26 8391692-1 1993 The antisense mRNA complementary to the sense strand of Metenkephalin encodes the antisense peptides, His-Glu-Ala-Pro-Ile (compound 88/62). Glutamic Acid 106-109 proopiomelanocortin Homo sapiens 56-69 7841367-1 1994 We have previously shown that a metabolically stable analogue of MPF, the C-terminal tetrapeptide of human beta-endorphin of structure Lys-Lys-Gly-Glu, reduces the turning behaviour of rats with unilateral lesions of their nigro-striatal pathways. Glutamic Acid 147-150 proopiomelanocortin Homo sapiens 107-121 1980269-0 1990 Synthesis and 11C-labelling of the ACTH fragment analogue H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (Org 2766) via its homocystine-containing precursor. Glutamic Acid 68-71 proopiomelanocortin Homo sapiens 35-39 1320420-5 1992 Since the vestibular ganglia of mammals are known to be glutaminergic, the present data further extends possibility that ACTH is co-localized with glutamate. Glutamic Acid 147-156 proopiomelanocortin Homo sapiens 121-125 34812835-0 2021 A buried glutamate in the cross-beta core renders beta-endorphin fibrils reversible. Glutamic Acid 9-18 proopiomelanocortin Homo sapiens 50-64 34812835-5 2021 Here, we investigate the critical role of a buried glutamate, Glu8, in the pH-responsive disassembly of beta-endorphin fibrils using all-atom molecular dynamics simulations along with structure-based pKa prediction. Glutamic Acid 51-60 proopiomelanocortin Homo sapiens 104-118 2552247-4 1989 Tryptic mapping of nexly synthetized alpha-MSH generated two fragments with the following amino acid composition: (T1) Trp, Pro, Lys, Gly, Val and (T2) Tyr, Arg, Phe, His, Ser, Glu. Glutamic Acid 177-180 proopiomelanocortin Homo sapiens 37-46 2574405-4 1989 Glutamic acid may be an important modulator of PRL and ACTH secretion in humans. Glutamic Acid 0-13 proopiomelanocortin Homo sapiens 55-59 2469648-1 1989 Monoclonal antibodies (MAB) were developed which recognize a peptide, His-Glu-Ala-Pro-Ile (HEAPI), encoded by the RNA complementary to the mRNA specifying [Met]-enkephalin. Glutamic Acid 74-77 proopiomelanocortin Homo sapiens 156-171 3031217-4 1987 The release of the putative neurotransmitter AAs glutamate (Glu), taurine (Tau), and glycine (Gly) were similarly increased by 50-150% with m-ENK in slices of CS, but not Cx. Glutamic Acid 49-58 proopiomelanocortin Homo sapiens 140-145 2898899-4 1988 These results suggest that ACTH and its fragments may act as anticonvulsants by antagonizing glutamate binding, their interaction with GABA-A sites may relate to the other central nervous effects of ACTH than the anticonvulsant activity. Glutamic Acid 93-102 proopiomelanocortin Homo sapiens 27-31 3031217-4 1987 The release of the putative neurotransmitter AAs glutamate (Glu), taurine (Tau), and glycine (Gly) were similarly increased by 50-150% with m-ENK in slices of CS, but not Cx. Glutamic Acid 60-63 proopiomelanocortin Homo sapiens 140-145 6111337-4 1981 beta-Endorphin has one Glu inside a predicted helical segment; its helicity in a NaDodSO4 solution is enhanced at pH below 4. Glutamic Acid 23-26 proopiomelanocortin Homo sapiens 0-14 6111337-5 1981 alpha-Melanocyte-stimulating hormone having a Glu in a beta segment undergoes a pH-induced coil to beta transition in 1.25 mM NaDodSO4 (excess surfactant will disrupt the beta form). Glutamic Acid 46-49 proopiomelanocortin Homo sapiens 0-36 223580-4 1978 The ACTH 4--9 analog H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (Org 2766) has behavioral activity after oral administration. Glutamic Acid 31-34 proopiomelanocortin Homo sapiens 4-8 33046908-3 2020 We find that beta-endorphin fibrils are in a beta-solenoid conformation with a protonated glutamate residue in their fibrillar core. Glutamic Acid 90-99 proopiomelanocortin Homo sapiens 13-27 212233-6 1976 The following conclusion was drawn: alpha-MSH possesses (in contrast to ACTH) two message sequences (active sites), (i)-Glu-His-Phe-Arg-Trp-, and (ii)-Gly-Lys-Pro-Val-NH2 which are capable of independently triggering the hormone receptor responsible for melanin dispersion. Glutamic Acid 120-123 proopiomelanocortin Homo sapiens 36-45 4375978-4 1974 It appears to be related to the beta-MSH species of mammalian species but has only the sequence -His-Phe-Arg-Trp- in common with the heptapeptide core -Met-Glu-His-Phe-Arg-Trp-Gly- which is characteristic not only of the MSH peptides but also of the adrenocorticotrophins and lipotrophins studied so far. Glutamic Acid 156-159 proopiomelanocortin Homo sapiens 32-40 194605-1 1977 The polypeptides ACTH and ATCH4-10 (OI 63) witha sequence of amino acids H-Met-Glu-His-Phe-Arg-Trp-Gly-OH, have similar stimulating effects on motor units in lower mammals. Glutamic Acid 79-82 proopiomelanocortin Homo sapiens 17-21 26944112-6 2016 CM from AS treated with ACTH protected OL from glutamate, NMDA, AMPA, quinolinic acid and ROS but not from kainate, staurosporine, NO or kynurenic acid. Glutamic Acid 47-56 proopiomelanocortin Homo sapiens 24-28 20642005-12 2004 A lactam bridge-cyclized alpha-MSH analog, GlyGlu-c[Lys-Nlc-Glu-His-d-Phe-Arg-Trp-Gly-Arg-Pro-Val-Asp] (GlyGlu-CycMSH), was conjugated with DOTA (11). Glutamic Acid 46-49 proopiomelanocortin Homo sapiens 25-34 25637483-9 2015 Central administration of alpha-MSH prevented the decrease in glutamate release, ERK phosphorylation and zif268 expression induced by IL-1beta. Glutamic Acid 62-71 proopiomelanocortin Homo sapiens 26-35 23440036-5 2013 Are GABA and glutamate or neuropeptides released from POMC neurons more crucial for modulating feeding and metabolism? Glutamic Acid 13-22 proopiomelanocortin Homo sapiens 54-58 24705707-0 2014 Reduction in glutamine/glutamate levels in the cerebral cortex after adrenocorticotropic hormone therapy in patients with west syndrome. Glutamic Acid 23-32 proopiomelanocortin Homo sapiens 69-96 23318874-10 2013 Dynorphin attenuated glutamate and GABA neurotransmission to POMC neurons. Glutamic Acid 21-30 proopiomelanocortin Homo sapiens 61-65 22522889-2 2012 Recent work shows that POMC neurons can also release the amino acid transmitters gamma-aminobutyric acid (GABA) and glutamate, although studying GABAergic and glutamatergic populations of POMC neurons has been hindered by the difficulty in reliably identifying amino acid (AA) transmitter phenotypes. Glutamic Acid 116-125 proopiomelanocortin Homo sapiens 23-27 17545153-7 2007 Further mutagenesis studies indicate that conserved residues Glu(100) in TM2, Asp(122), Asp(126) in TM3 and Trp(258), Phe(261), His(264) in TM6 are involved in alpha-MSH binding and signaling. Glutamic Acid 61-64 proopiomelanocortin Homo sapiens 160-169 19486656-11 2009 A glutamate mechanism is implied in the long-term amphetamine-induced effects at immune level and in the met-enkephalin from NAc and spleen. Glutamic Acid 2-11 proopiomelanocortin Homo sapiens 105-119