PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16395068-13	2006	However, in children heterozygous for Glu at position 27 of the beta2-adrenergic receptor, the percentage of patients requiring aminophylline treatment, in addition to beta2-agonist therapy, was significantly higher than that seen in patients homozygous for Gln at that position (5/10 [50%] vs. 1/21 [5%], respectively; p = .002).	Glutamic Acid	38-41	adrenoceptor beta 2	Homo sapiens	64-89	
17374341-3	2007	In 597 patients treated by a beta-blocker and followed for 3 years after a myocardial infarction or an acute coronary syndrome, the death rate was 5.4 times higher in homozygous Arg 16 and Gln 27 B2AR genotypes than in heterozygous or homozygous Gly 16 and Glu 27 B2AR genotypes.	Glutamic Acid	257-260	adrenoceptor beta 2	Homo sapiens	196-200	
17374341-5	2007	In a second study, in a prospective cohort of 5249 patients aged > or =65 years, the incidence of sudden cardiac death was 1.56 times higher in patients with homozygous Gln 27 B2AR than in heterozygous or homozygous Glu 27 B2AR genotype.	Glutamic Acid	219-222	adrenoceptor beta 2	Homo sapiens	179-183	
16571957-15	2006	CONCLUSIONS: Glycine at position 16 and/or glutamate at position 27 of the beta2AR leads to lower vasopressor use for treatment of hypotension during spinal anesthesia.	Glutamic Acid	43-52	adrenoceptor beta 2	Homo sapiens	75-82	
16395068-14	2006	CONCLUSIONS: African American children with status asthmaticus who have the Gln/Glu genotype at amino acid position 27 of the beta2-adrenergic receptor may benefit from aminophylline treatment in addition to beta2-agonist therapy.	Glutamic Acid	80-83	adrenoceptor beta 2	Homo sapiens	126-151	
14715679-4	2004	The beta2-AR genotype also was independently associated with a-vDO2 during submaximal (P = 0.004) and approximately 100% maximal O2 uptake exercise (P = 0.006), with a 1.2-2 ml/100 ml greater a-vDO2 in the Gln/Gln than in the Glu/Glu genotype women.	Glutamic Acid	226-229	adrenoceptor beta 2	Homo sapiens	4-12	
16369119-1	2006	BACKGROUND: beta(2)-Adrenergic receptor (beta(2)-AR) polymorphisms occurring at amino acid position 16 (Arg-Gly) and 27 (Gln-Glu) are known to be functionally relevant and also disease-modifying in subjects with asthma.	Glutamic Acid	125-128	adrenoceptor beta 2	Homo sapiens	12-39	
16369119-1	2006	BACKGROUND: beta(2)-Adrenergic receptor (beta(2)-AR) polymorphisms occurring at amino acid position 16 (Arg-Gly) and 27 (Gln-Glu) are known to be functionally relevant and also disease-modifying in subjects with asthma.	Glutamic Acid	125-128	adrenoceptor beta 2	Homo sapiens	41-51	
16369119-7	2006	RESULTS: There was a significant difference of serum IgE levels among three beta(2)-AR 27 loci groups (p < 0.0001), with the highest IgE level [(1.24 +/- 0.25) x 10(6) IU/l] in the Gln/Gln group and the lowest IgE level [(0.48 +/- 0.06) x 10(6) IU/l] in the Glu/Glu group.	Glutamic Acid	261-264	adrenoceptor beta 2	Homo sapiens	76-86	
16369119-7	2006	RESULTS: There was a significant difference of serum IgE levels among three beta(2)-AR 27 loci groups (p < 0.0001), with the highest IgE level [(1.24 +/- 0.25) x 10(6) IU/l] in the Gln/Gln group and the lowest IgE level [(0.48 +/- 0.06) x 10(6) IU/l] in the Glu/Glu group.	Glutamic Acid	265-268	adrenoceptor beta 2	Homo sapiens	76-86	
15946904-3	2005	RESULTS: Three common polymorphisms were abundant in at least one allele in beta2AR resulting in a cysteine to arginine in the 5" promoter region (72% of patients), an arginine to glycine at amino acid-16 (Gly16; 86%), and a glutamine to glutamic acid at amino acid-27 (Glu27; 66%), a frequency that was no different to the normal Caucasian population.	Glutamic Acid	238-251	adrenoceptor beta 2	Homo sapiens	76-83	
14715679-4	2004	The beta2-AR genotype also was independently associated with a-vDO2 during submaximal (P = 0.004) and approximately 100% maximal O2 uptake exercise (P = 0.006), with a 1.2-2 ml/100 ml greater a-vDO2 in the Gln/Gln than in the Glu/Glu genotype women.	Glutamic Acid	230-233	adrenoceptor beta 2	Homo sapiens	4-12	
12460637-4	2002	Homology of the translated protein with the human beta(2)-adrenoceptor was 88% with Ala at position 16 and Glu at position 27.	Glutamic Acid	107-110	adrenoceptor beta 2	Homo sapiens	50-70	
14510910-11	2003	CONCLUSIONS: Our results suggest that the glutamic acid 27 allele of the beta2-adrenoceptor may be a risk factor in men but not in women for the accumulation of visceral fat and for its association with the development of type 2 diabetes mellitus.	Glutamic Acid	42-55	adrenoceptor beta 2	Homo sapiens	73-91	
14557466-2	2003	The goal of the present study was to assess the association between the Gly(16)-->Arg(16) and Gln(27)-->Glu(27) polymorphisms of the beta(2)-adrenergic receptor and metabolic syndrome.	Glutamic Acid	110-113	adrenoceptor beta 2	Homo sapiens	139-166	
12885990-4	2003	METHODS: The prevalence of two ADRB2 polymorphisms, Arg16-->Gly and Gln27-->Glu, was examined in 587 smokers chosen from the NHLBI Lung Health Study for having the fastest (n=282) and slowest (n=305) 5 year rate of decline in forced expiratory volume in 1 second (FEV(1); mean DeltaFEV(1) -4.14 and +1.08% predicted/year, respectively).	Glutamic Acid	82-85	adrenoceptor beta 2	Homo sapiens	31-36	
12824951-7	2003	The blood glucose and insulin concentration during OGTT and blood FFA and TG level during OLTT was lower in patients with the Glu/Glu b2-AR polymorphism than Glu/Gln and Gln/Gln.	Glutamic Acid	126-129	adrenoceptor beta 2	Homo sapiens	134-139	
12824951-7	2003	The blood glucose and insulin concentration during OGTT and blood FFA and TG level during OLTT was lower in patients with the Glu/Glu b2-AR polymorphism than Glu/Gln and Gln/Gln.	Glutamic Acid	130-133	adrenoceptor beta 2	Homo sapiens	134-139	
12824951-7	2003	The blood glucose and insulin concentration during OGTT and blood FFA and TG level during OLTT was lower in patients with the Glu/Glu b2-AR polymorphism than Glu/Gln and Gln/Gln.	Glutamic Acid	130-133	adrenoceptor beta 2	Homo sapiens	134-139	
11879211-5	2002	Using multiple linear regression models, controlling for age, sex, weight, baseline blood pressure, heart rate and rate pressure product, we found that patients who possessed the glutamic acid homozygote of beta2AR-27 produced significantly greater changes in mean arterial pressure and rate pressure products than patients with the glutamine homozygote of beta2AR-27 (beta coefficient for mean blood pressure = 11.81, beta coefficient for pulse-pressure product = 8.76, both p-values = 0.023).	Glutamic Acid	179-192	adrenoceptor beta 2	Homo sapiens	207-214	
11879211-5	2002	Using multiple linear regression models, controlling for age, sex, weight, baseline blood pressure, heart rate and rate pressure product, we found that patients who possessed the glutamic acid homozygote of beta2AR-27 produced significantly greater changes in mean arterial pressure and rate pressure products than patients with the glutamine homozygote of beta2AR-27 (beta coefficient for mean blood pressure = 11.81, beta coefficient for pulse-pressure product = 8.76, both p-values = 0.023).	Glutamic Acid	179-192	adrenoceptor beta 2	Homo sapiens	357-364	
11434877-5	2001	RESULTS: Twenty-five (12.4%) breast cancer patients and 32 (17.6%) control individuals were found to bear a glutamic acid (Glu) allele for the ADRB2 gene (odds ratio [OR] 0.67, 95% confidence interval [CI] 0.38-1.18), and 60 (30.0%) breast cancer patients and 61 (33.5%) control individuals were found to bear an Arg allele for the ADRB3 gene (OR 0.85, 95% CI 0.55-1.31).	Glutamic Acid	108-121	adrenoceptor beta 2	Homo sapiens	143-148	
11434877-5	2001	RESULTS: Twenty-five (12.4%) breast cancer patients and 32 (17.6%) control individuals were found to bear a glutamic acid (Glu) allele for the ADRB2 gene (odds ratio [OR] 0.67, 95% confidence interval [CI] 0.38-1.18), and 60 (30.0%) breast cancer patients and 61 (33.5%) control individuals were found to bear an Arg allele for the ADRB3 gene (OR 0.85, 95% CI 0.55-1.31).	Glutamic Acid	123-126	adrenoceptor beta 2	Homo sapiens	143-148	
10652295-7	2000	In addition, we found that the pH sensitivity of beta(2)AR activation is not abrogated by mutation of Asp(130), which is homologous to the highly conserved acidic amino acids that link protonation to activation of rhodopsin (Glu(134)) and the alpha(1B) adrenergic receptor (Asp(142)).	Glutamic Acid	225-228	adrenoceptor beta 2	Homo sapiens	49-58	
10872649-1	2000	BACKGROUND AND OBJECTIVES: The most common polymorphisms of the human beta2-adrenergic receptor--Arg16-->Gly and Gln27-->Glu--are associated with alterations in beta2-adrenergic receptor responses, both in vitro and in vivo.	Glutamic Acid	127-130	adrenoceptor beta 2	Homo sapiens	70-95	
10872649-5	2000	A polymerase chain reaction-based single-stranded conformational polymorphism method with direct sequencing of the bands of interest was used to detect the two frequently occurring beta2-adrenergic receptor variants (Arg16-->Gly, Gln27-->Glu).	Glutamic Acid	244-247	adrenoceptor beta 2	Homo sapiens	181-206	
11778498-4	2000	The beta 2-AR 27 loci: Gln/Gln genotype accounts for 36%, Gln/Glu 55% and Glu/Glu 9%.	Glutamic Acid	62-65	adrenoceptor beta 2	Homo sapiens	4-13	
11778498-4	2000	The beta 2-AR 27 loci: Gln/Gln genotype accounts for 36%, Gln/Glu 55% and Glu/Glu 9%.	Glutamic Acid	74-77	adrenoceptor beta 2	Homo sapiens	4-13	
11778498-4	2000	The beta 2-AR 27 loci: Gln/Gln genotype accounts for 36%, Gln/Glu 55% and Glu/Glu 9%.	Glutamic Acid	74-77	adrenoceptor beta 2	Homo sapiens	4-13	
11778498-8	2000	The frequency of genotype beta 2-AR 27 loci in asthmatics: Gln/Gln genotype accounts for 34%, Gln/Glu 56% and Glu/Glu 10%.	Glutamic Acid	98-101	adrenoceptor beta 2	Homo sapiens	26-35	
11778498-8	2000	The frequency of genotype beta 2-AR 27 loci in asthmatics: Gln/Gln genotype accounts for 34%, Gln/Glu 56% and Glu/Glu 10%.	Glutamic Acid	110-113	adrenoceptor beta 2	Homo sapiens	26-35	
11778498-8	2000	The frequency of genotype beta 2-AR 27 loci in asthmatics: Gln/Gln genotype accounts for 34%, Gln/Glu 56% and Glu/Glu 10%.	Glutamic Acid	110-113	adrenoceptor beta 2	Homo sapiens	26-35	
7915137-9	1994	Arg16-->Gly+Gln27-->Glu also underwent an increased downregulation compared to wild-type beta 2AR (39 +/- 4%).	Glutamic Acid	26-29	adrenoceptor beta 2	Homo sapiens	95-103	
7739309-0	1995	Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects.	Glutamic Acid	15-18	adrenoceptor beta 2	Homo sapiens	22-41	
7739309-1	1995	Cells expressing the Glu 27 beta 2-adrenoceptor polymorphism show attenuated down-regulation of the receptor after long-term exposure to agonist.	Glutamic Acid	21-24	adrenoceptor beta 2	Homo sapiens	28-47	
7739309-2	1995	We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma.	Glutamic Acid	52-55	adrenoceptor beta 2	Homo sapiens	11-30	
29658513-5	2018	The presence of heterozygous Arg-Gly and Gln-Glu gives a better response to drug therapy than the presence of Gly-Gly and Glu-Glu genotypes at codons 16 and 27.ConclusionPolymorphism of beta2AR at codons 16 and 27 correlates with asthma severity and response to treatment in asthmatic children.	Glutamic Acid	45-48	adrenoceptor beta 2	Homo sapiens	186-193	
27330078-9	2016	Residue Glu-355 in Galphaq prevents this peptide from interacting strongly with beta2-AR.	Glutamic Acid	8-11	adrenoceptor beta 2	Homo sapiens	80-88	
27027728-6	2016	Four selected polymorphisms were determined: beta1 -adrenergic receptor polymorphisms Ser(49) Gly and Arg(389) Gly and beta2 -adrenergic receptor polymorphisms Arg(16) Gly and Gln(27) Glu.	Glutamic Acid	184-187	adrenoceptor beta 2	Homo sapiens	119-145	
21613201-14	2011	In a multiple linear regression model (R2 = 63.6%; P = 0.03), neonatal ADRB2 genotypes (p.16Arg/Arg and p.27Gln/Glu) and lower neonatal birth weight predicted lower UA lactate concentrations.	Glutamic Acid	112-115	adrenoceptor beta 2	Homo sapiens	71-76	
23911093-6	2013	Gln/Gln carriers of the ADRB2 gene had smaller gynoid fat-% compared with both the Gln/Glu and Glu/Glu carriers (p=0.050 and p=0.009, respectively).	Glutamic Acid	87-90	adrenoceptor beta 2	Homo sapiens	24-29	
23911093-6	2013	Gln/Gln carriers of the ADRB2 gene had smaller gynoid fat-% compared with both the Gln/Glu and Glu/Glu carriers (p=0.050 and p=0.009, respectively).	Glutamic Acid	95-98	adrenoceptor beta 2	Homo sapiens	24-29	
23911093-6	2013	Gln/Gln carriers of the ADRB2 gene had smaller gynoid fat-% compared with both the Gln/Glu and Glu/Glu carriers (p=0.050 and p=0.009, respectively).	Glutamic Acid	95-98	adrenoceptor beta 2	Homo sapiens	24-29	
22048503-1	2011	BACKGROUND AND OBJECTIVES: Several polymorphisms of the beta2-adrenergic receptor (beta2-AR) gene have been identified, including the amino acid substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic acid (Glu) at codon 27.	Glutamic Acid	235-248	adrenoceptor beta 2	Homo sapiens	56-81	
22048503-1	2011	BACKGROUND AND OBJECTIVES: Several polymorphisms of the beta2-adrenergic receptor (beta2-AR) gene have been identified, including the amino acid substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic acid (Glu) at codon 27.	Glutamic Acid	235-248	adrenoceptor beta 2	Homo sapiens	83-91	
22048503-1	2011	BACKGROUND AND OBJECTIVES: Several polymorphisms of the beta2-adrenergic receptor (beta2-AR) gene have been identified, including the amino acid substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic acid (Glu) at codon 27.	Glutamic Acid	250-253	adrenoceptor beta 2	Homo sapiens	56-81	
22048503-1	2011	BACKGROUND AND OBJECTIVES: Several polymorphisms of the beta2-adrenergic receptor (beta2-AR) gene have been identified, including the amino acid substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic acid (Glu) at codon 27.	Glutamic Acid	250-253	adrenoceptor beta 2	Homo sapiens	83-91	
21038778-1	2010	The genetic polymorphisms at the 16th (Arg--> Gly) and 27th (Gln-->Glu) amino acid positions of the beta2-adrenergic receptor (ADRB2) may be linked to various asthma-related phenotypes.	Glutamic Acid	73-76	adrenoceptor beta 2	Homo sapiens	106-131	
21572694-1	2011	BACKGROUND AND OBJECTIVES: Two polymorphisms of beta(2)-adrenergic receptor (beta(2)-AR) gene, namely the substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic (Glu) at codon 27, are linked with functional changes in the beta(2)-AR in the respiratory system even though they are not deemed to be susceptibility genes for asthma per se.	Glutamic Acid	206-209	adrenoceptor beta 2	Homo sapiens	48-75	
21572694-1	2011	BACKGROUND AND OBJECTIVES: Two polymorphisms of beta(2)-adrenergic receptor (beta(2)-AR) gene, namely the substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic (Glu) at codon 27, are linked with functional changes in the beta(2)-AR in the respiratory system even though they are not deemed to be susceptibility genes for asthma per se.	Glutamic Acid	206-209	adrenoceptor beta 2	Homo sapiens	77-87	
19441602-1	2009	BACKGROUND: Beta 2-Adrenergic receptor polymorphisms occurring at amino acid positions 16 (arginine/glycine) and 27 (glutamine/glutamic acid) are known to be functionally relevant.	Glutamic Acid	127-140	adrenoceptor beta 2	Homo sapiens	12-38	
19301767-7	2008	Furthermore, the frequency of beta2-AR Glu allele was higher among patients with a history of acute myocardial infarction (with infarction: 0.534, without: 0.313, p = 0.01).	Glutamic Acid	39-42	adrenoceptor beta 2	Homo sapiens	30-38	
19301767-5	2008	RESULTS: The presence of beta2-AR Glu allele was a risk predictor for HF (odds ratio (OR) = 2.81; 95% confidence intervals (CI) = 1.49-5.31).	Glutamic Acid	34-37	adrenoceptor beta 2	Homo sapiens	25-33	
19301767-6	2008	Interactions that increased the risk for HF were found in patients carrying at least one of the beta2-AR Glu and beta2-AR Gly allele (OR = 3.81; 95% CI = 1.50-0.70) and beta2-AR Glu and beta1-AR Gly allele combination (OR = 5.51; 95% CI = 2.19-13.86).	Glutamic Acid	105-108	adrenoceptor beta 2	Homo sapiens	96-104	
18714823-5	2008	beta2-AR genotypes and allele frequencies at amino acid positions 16 (beta2-AR-16: Arg-->Gly) and 27 (beta2-AR-27: Gln-->Glu) were identified by PCR-RFLP.	Glutamic Acid	127-130	adrenoceptor beta 2	Homo sapiens	0-8	
17094995-11	2007	CONCLUSIONS: In patients at high risk for CAD and/or angina-like pain, Glu-27 allele of beta2 adrenergic receptor polymorphism is an independent risk factor for CAD and appears to be associated with higher incidence of myocardial revascularization.	Glutamic Acid	71-74	adrenoceptor beta 2	Homo sapiens	88-113