PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15732101-5 2005 We have identified four mutations in senataxin in the French-Canadian population including two novel missense mutations: the 5927T-->G mutation changes the leucine encoded by codon 1976 to an arginine in the helicase domain (L1976R), and the 193G-->A mutation changes a glutamic acid encoded by codon 65 into a lysine in the N-terminal domain of the protein (E65K). Glutamic Acid 276-289 senataxin Homo sapiens 37-46