PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27126696-6 2016 We generated and employed a CHO-DG44 cell clone producing an rFVIII variant retaining a portion of the B-domain and the FVIII native cleavage site between Arg(1648) and Glu(1649). Glutamic Acid 169-172 coagulation factor VIII Homo sapiens 62-67 20735721-9 2010 FVIII bound to Glu-Gly-Arg-active-site-modified FVIIa (K(d), ~0.8 nM) with a higher affinity for the HCh than for the LCh (K(d), 5.9 and 18.9 nm). Glutamic Acid 15-18 coagulation factor VIII Homo sapiens 0-5 16839343-2 2006 Previously, we have demonstrated that region Glu(1811)-Lys(1818) within FVIII light chain constitutes an important binding region for this receptor. Glutamic Acid 45-48 coagulation factor VIII Homo sapiens 72-77 12522143-9 2003 In line with this observation, LRP binding was inhibited by a recombinant antibody fragment that specifically binds to the FVIII sequence Glu(1811)-Lys(1818). Glutamic Acid 138-141 coagulation factor VIII Homo sapiens 123-128 14629468-3 2003 Results of these studies indicate that in the presence of FX (1.5 micro m), the enzyme (active-site-inhibited Glu-Gly-Arg-FIXa, EGR-FIXa) and procofactor (FVIII) bind to an equal number (approximately 700 sites/platelet) of receptors whereas the active cofactor (FVIIIa) binds an additional approximately 500 high-affinity FVIIIa binding sites per platelet (Kd approximately 0.8 nm). Glutamic Acid 110-113 coagulation factor VIII Homo sapiens 155-160 12522143-12 2003 This suggests that multiple sites in FVIII contribute to high-affinity LRP binding, one of which is the FVIII A3 domain region Glu(1811)-Lys(1818). Glutamic Acid 127-130 coagulation factor VIII Homo sapiens 37-42 12522143-12 2003 This suggests that multiple sites in FVIII contribute to high-affinity LRP binding, one of which is the FVIII A3 domain region Glu(1811)-Lys(1818). Glutamic Acid 127-130 coagulation factor VIII Homo sapiens 104-109 7974349-3 1994 The epitopes of MAbs 418 and 522, which inhibit the binding of vWF to Factor VIII (FVIII), were localized between Leu 2 and Arg 53 and between Glu 35 and Ile 81 of the vWF subunit respectively, within the N-terminal trypsin fragment called SpIII-T4 [amino acids (aa) 1-272] which contains a binding domain for FVIII. Glutamic Acid 143-146 coagulation factor VIII Homo sapiens 70-81 7974349-3 1994 The epitopes of MAbs 418 and 522, which inhibit the binding of vWF to Factor VIII (FVIII), were localized between Leu 2 and Arg 53 and between Glu 35 and Ile 81 of the vWF subunit respectively, within the N-terminal trypsin fragment called SpIII-T4 [amino acids (aa) 1-272] which contains a binding domain for FVIII. Glutamic Acid 143-146 coagulation factor VIII Homo sapiens 83-88 3150544-2 1988 One of these new derivatives, FVIII delta II, in which amino acids 771(pro)-1666(asp) have been deleted, no longer contains the protease cleavage site at amino acid position 1648(arg)-1649(glu) known to be involved in the initial step of FVIII processing. Glutamic Acid 189-192 coagulation factor VIII Homo sapiens 30-35