PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26861418-12 2016 These results indicate that local PVN glutamate neurotransmission is involved in the neural pathway mediating cardiovascular responses to hemorrhage, via an integrated control involving autonomic nervous system activity and vasopressin release into the circulation. Glutamic Acid 38-47 arginine vasopressin Rattus norvegicus 224-235 31369731-5 2019 We show that stimulation with l-glutamate robustly induced AVP gene expression in acute hypothalamic brain slices containing the PVN. Glutamic Acid 30-41 arginine vasopressin Rattus norvegicus 59-62 28862781-4 2017 The vasopressin neurones are predominantly located in the layer II of the PC and the majority co-express the excitatory transmitter glutamate. Glutamic Acid 132-141 arginine vasopressin Rattus norvegicus 4-15 25043186-5 2014 Ang II does this by inducing cell-autonomous release of nitric oxide by VP neurons and endocannabinoids by OT neurons to respectively enhance and reduce glutamate release by osmoreceptor afferents. Glutamic Acid 153-162 arginine vasopressin Rattus norvegicus 72-74 27065810-0 2016 Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway? Glutamic Acid 131-140 arginine vasopressin Rattus norvegicus 119-130 22396452-1 2012 We report changes in plasma arginine vasopressin (AVP) and oxytocin (OT) concentrations evoked by the microinjection of l-glutamate (l-glu) into the hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN) of unanesthetized rats, as well as which local mechanisms are involved in their mediation. Glutamic Acid 120-131 arginine vasopressin Rattus norvegicus 37-48 23525323-5 2013 Peripheral treatment with the combination of prazosin, atenolol and the vasopressin V1 antagonist abolished the pressor effect of glutamate; however, this treatment produced only a small decrease in the pressor effect of angiotensin-(1-7) at the rostral ventrolateral medulla. Glutamic Acid 130-139 arginine vasopressin Rattus norvegicus 72-83 22396452-1 2012 We report changes in plasma arginine vasopressin (AVP) and oxytocin (OT) concentrations evoked by the microinjection of l-glutamate (l-glu) into the hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN) of unanesthetized rats, as well as which local mechanisms are involved in their mediation. Glutamic Acid 120-125 arginine vasopressin Rattus norvegicus 37-48 22279215-3 2012 Whereas glutamate release was facilitated in oxytocin (OT) neurons, it was inhibited in vasopressin (VP) cells. Glutamic Acid 8-17 arginine vasopressin Rattus norvegicus 88-99 12535160-2 2003 To test whether synaptic glutamate release is modulated by these neuropeptides, we examined the combined effect of vasopressin and oxytocin on depolarization-induced glutamate and aspartate release from acutely dissected rat SON or fronto-parietal cortex punches. Glutamic Acid 166-175 arginine vasopressin Rattus norvegicus 115-126 20163519-1 2010 Release of arginine vasopressin (AVP) and oxytocin from magnocellular neurosecretory cells (MNCs) of the supraoptic nucleus (SON) is under the control of glutamate-dependent excitation and GABA-dependent inhibition. Glutamic Acid 154-163 arginine vasopressin Rattus norvegicus 11-37 18280467-14 2008 Central vasopressin can modulate cardiovascular parameters by causing excitation of spinal sympathetic preganglionic neurons, by increasing the inhibitory input to cardiac parasympathetic neurons in the nucleus ambiguus, by depressing the excitatory input to parabrachial neurons, or by inhibiting glutamate release at solitary tract axon terminals. Glutamic Acid 298-307 arginine vasopressin Rattus norvegicus 8-19 17877638-0 2007 Arginine vasopressin increases glutamate release and intracellular Ca2+ concentration in hippocampal and cortical astrocytes through two distinct receptors. Glutamic Acid 31-40 arginine vasopressin Rattus norvegicus 9-20 17367824-5 2007 The pressor and bradycardic response to L-glu was potentiated by intravenous pretreatment with the ganglion blocker pentolinium and was blocked by intravenous pretreatment with the V1-vasopressin receptor antagonist dTyr(CH2)5(Me)AVP, suggesting involvement of circulating vasopressin in this response. Glutamic Acid 40-45 arginine vasopressin Rattus norvegicus 184-195 17367824-5 2007 The pressor and bradycardic response to L-glu was potentiated by intravenous pretreatment with the ganglion blocker pentolinium and was blocked by intravenous pretreatment with the V1-vasopressin receptor antagonist dTyr(CH2)5(Me)AVP, suggesting involvement of circulating vasopressin in this response. Glutamic Acid 40-45 arginine vasopressin Rattus norvegicus 273-284 17367824-6 2007 Additionally L-glu microinjection into the SON increased plasma vasopressin levels (control: 1.3 +/- 0.2 pg/mL, n = 6; L-glu: 14.7+/-2.3 pg/mL, n=6). Glutamic Acid 13-18 arginine vasopressin Rattus norvegicus 64-75 17367824-7 2007 In conclusion the results suggest that pressor responses to SON microinjection of L-glu are caused by activation of non-NMDA glutamate receptors and mediated by vasopressin release into systemic circulation. Glutamic Acid 82-87 arginine vasopressin Rattus norvegicus 161-172 12535160-5 2003 In the presence of vasopressin/oxytocin, K+-stimulated glutamate and aspartate release were significantly reduced by 34% and 62%, respectively, in the SON. Glutamic Acid 55-64 arginine vasopressin Rattus norvegicus 19-30 12535160-7 2003 The effects of exogenous neuropeptides are likely mediated by oxytocin and/or vasopressin receptors, as the oxytocin- and V1a-receptor antagonist, Manning Compound (10-100 micro m), partially reversed the effects of vasopressin/oxytocin on SON glutamate release. Glutamic Acid 244-253 arginine vasopressin Rattus norvegicus 78-89 8758945-1 1996 The present ultrastructural study analysed the distribution of glutamatergic synapses on oxytocin- and vasopressin-secreting neurons in the rat supraoptic nucleus (SON) after post-embedding immunogold labelling for glutamate immunoreactivity, visible over synaptic-like vesicles, mitochondria and synaptic densities. Glutamic Acid 63-72 arginine vasopressin Rattus norvegicus 103-114 11457436-4 2001 Iontophoresis of L-glutamate or vasopressin into the vicinity of a vasomotor neurone increased activity, effects which were blocked by simultaneous iontophoretic application of a glutamate receptor antagonist, or a vasopressin V(1a) antagonist respectively. Glutamic Acid 17-28 arginine vasopressin Rattus norvegicus 215-226 11208557-1 2001 Glutamate is recognized as a prominent excitatory transmitter in the supraoptic nucleus (SON) and is involved in transmission of osmoregulatory information from the osmoreceptors to the vasopressin (VP) and oxytocin (OT) neurons. Glutamic Acid 0-9 arginine vasopressin Rattus norvegicus 186-197 10515959-2 1999 AVP reversibly decreased the amplitude of the evoked, glutamate-mediated, excitatory postsynaptic current (EPSC) with an increase in paired-pulse ratio. Glutamic Acid 54-63 arginine vasopressin Rattus norvegicus 0-3 10074795-4 1998 Microinotophoretically administered VP excited single neurons in the lateral septum of ventral hippocampus, and/or facilitated the responses of these neurons to glutamate and to stimulation of the glutamatergic afferent fibers in the fimbria bundle. Glutamic Acid 161-170 arginine vasopressin Rattus norvegicus 36-38 12493620-8 2003 The pressor response to L-glutamate (30 nmol/200 nl) into the dbB was blocked by intravenous pretreatment with the vasopressin antagonist dTyr(CH(2))(5)(Me)AVP (50 microg/kg), suggesting the involvement of circulating vasopressin in this response. Glutamic Acid 24-35 arginine vasopressin Rattus norvegicus 115-126 12493620-8 2003 The pressor response to L-glutamate (30 nmol/200 nl) into the dbB was blocked by intravenous pretreatment with the vasopressin antagonist dTyr(CH(2))(5)(Me)AVP (50 microg/kg), suggesting the involvement of circulating vasopressin in this response. Glutamic Acid 24-35 arginine vasopressin Rattus norvegicus 218-229 12493620-9 2003 Further evidence of the involvement of the endocrine vasopressin system in the pressor response to L-glutamate injected into the dbB was provided by hypophysectomy since L-glutamate (30 nmol/200 nl) microinjection into the dbB of hypophysectomized rats caused only depressor responses. Glutamic Acid 99-110 arginine vasopressin Rattus norvegicus 53-64 12493620-9 2003 Further evidence of the involvement of the endocrine vasopressin system in the pressor response to L-glutamate injected into the dbB was provided by hypophysectomy since L-glutamate (30 nmol/200 nl) microinjection into the dbB of hypophysectomized rats caused only depressor responses. Glutamic Acid 170-181 arginine vasopressin Rattus norvegicus 53-64 12493620-10 2003 We presently report that chemical stimulation of the dbB with L-glutamate caused only pressor responses in unanesthetized rats that were mediated by vasopressin release into the systemic circulation. Glutamic Acid 62-73 arginine vasopressin Rattus norvegicus 149-160 11535665-1 2001 Oxytocin and vasopressin release from magnocellular neurons of the supraoptic nucleus is under the control of glutamate-dependent excitation. Glutamic Acid 110-119 arginine vasopressin Rattus norvegicus 13-24 10422942-7 1999 This inhibition by propofol was not reversed by picrotoxin, a gamma-aminobutyric acid(A)(GABA(A)) receptor antagonist, whereas arginine vasopressin release induced by glutamate (10(-3) M) was also inhibited by propofol at a clinically relevant concentration (10(-6) M). Glutamic Acid 167-176 arginine vasopressin Rattus norvegicus 136-147 9650803-9 1998 Our results document: i) the importance of the PAG area in the control of cardiovascular system; ii) the involvement of excitatory amino acids in the neural control of vasopressin release; iii) the close relationship between glutamate and vasopressin in the central blood pressure regulation. Glutamic Acid 225-234 arginine vasopressin Rattus norvegicus 168-179 8762104-0 1996 Presynaptic modulation by L-glutamate and GABA of sympathetic co-transmission in rat isolated vas deferens. Glutamic Acid 26-37 arginine vasopressin Rattus norvegicus 94-97 7799221-5 1994 Trains of repetitive 5-30 Hz stimulation, or microinfusion of glutamate into the MnPO, similarly induced a cessation in spontaneous phasic or continuous firing in 17/18 and 17/20 vasopressin neurones, respectively. Glutamic Acid 62-71 arginine vasopressin Rattus norvegicus 179-190 8713175-5 1995 injection of vasopressin V1-receptor antagonist, (d(CH2)5(1), O-Me-Tyr2, Arg8)-vasopressin (10 micrograms/kg), markedly attenuated the effects of L-glutamate but not of L-cysteine. Glutamic Acid 146-157 arginine vasopressin Rattus norvegicus 13-24 8713175-5 1995 injection of vasopressin V1-receptor antagonist, (d(CH2)5(1), O-Me-Tyr2, Arg8)-vasopressin (10 micrograms/kg), markedly attenuated the effects of L-glutamate but not of L-cysteine. Glutamic Acid 146-157 arginine vasopressin Rattus norvegicus 79-90 7709793-1 1994 Studies were carried out in the rat to investigate whether glutamic acid is involved in the regulation of vasopressin (VP) release. Glutamic Acid 59-72 arginine vasopressin Rattus norvegicus 106-117 7709793-1 1994 Studies were carried out in the rat to investigate whether glutamic acid is involved in the regulation of vasopressin (VP) release. Glutamic Acid 59-72 arginine vasopressin Rattus norvegicus 119-121 7709793-2 1994 For this purpose plasma VP levels were measured in rats treated with the glutamate agonist N-methyl-D-aspartate (NMDA). Glutamic Acid 73-82 arginine vasopressin Rattus norvegicus 24-26 7709793-5 1994 These data show that glutamate may contribute to the physiological release of VP from the neurohypophysis. Glutamic Acid 21-30 arginine vasopressin Rattus norvegicus 78-80 1687373-5 1991 Stimulation of the vasopressin/oxytocin neurosecretory system by water deprivation increased glutamate content in pituicytes and mitochondria within neurosecretory endings but had little influence on microvesicle glutamate content. Glutamic Acid 93-102 arginine vasopressin Rattus norvegicus 19-30 7904278-4 1993 Parabrachial nucleus injections of the neuroexcitant glutamate (0.2, 10 or 200 mM) altered the activity of only 6% of vasopressin cells tested (118 tests). Glutamic Acid 53-62 arginine vasopressin Rattus norvegicus 118-129 19215500-2 1991 Glutamate immunoreactivity has been found in axon terminals forming asymmetric synapses on to magnocellular neurosecretory cells and kynurenic acid, a broad spectrum glutamate receptor antagonist inhibits 1) spontaneous electrical activity in vivo, 2) excitatory postsynaptic potentials in hypothalamic slices, and 3) osmotically-evoked vasopressin release from hypothalamic explants. Glutamic Acid 0-9 arginine vasopressin Rattus norvegicus 337-348 1971460-4 1990 The remaining DLS neurons treated with these vasopressin concentrations showed an increase in glutamate-mediated excitatory postsynaptic potentials (EPSPs), evoked by stimulation of the fimbria fibers. Glutamic Acid 94-103 arginine vasopressin Rattus norvegicus 45-56 1979156-3 1990 A selective antagonist of vasopressin V1 receptors suppressed the VP-induced excitation and, in addition, suppressed the excitations induced by Glu but not those by ACh. Glutamic Acid 144-147 arginine vasopressin Rattus norvegicus 26-37 1979156-5 1990 Two excitatory amino acid antagonists, D(-)-2-amino-5-phosphonovaleric acid (2APV) and glutamic acid diethyl ester (GDEE), suppressed the responses to Glu and also those to VP. Glutamic Acid 151-154 arginine vasopressin Rattus norvegicus 173-175 1979156-9 1990 The increase in Glu responses induced by VP could not be prevented by the VP or excitatory amino acid receptor antagonists applied before the peptide. Glutamic Acid 16-19 arginine vasopressin Rattus norvegicus 41-43 1979156-10 1990 The possibility that the excitation and the potentiation of Glu responses caused by VP originated from two different actions of the peptide is discussed. Glutamic Acid 60-63 arginine vasopressin Rattus norvegicus 84-86 2896801-0 1988 Glutamate and kainate effects on the noradrenergic neurons innervating the rat vas deferens. Glutamic Acid 0-9 arginine vasopressin Rattus norvegicus 79-82 34423030-1 2021 Here, we report the participation of N-methyl-D-aspartate (NMDA) glutamate receptor in the mediation of cardiovascular and circulating vasopressin responses evoked by a hemorrhagic stimulus. Glutamic Acid 65-74 arginine vasopressin Rattus norvegicus 135-146 2563205-2 1989 Activation of PVN neurons with L-glutamate led to increases in plasma ACTH, vasopressin, and oxytocin and a profound bradycardia (approximately 80 beats/min) with little change in arterial blood pressure. Glutamic Acid 31-42 arginine vasopressin Rattus norvegicus 76-87 3044528-6 1988 Iontophoretic studies indicate that AVP inhibits glutamate-stimulated activity of thermoresponsive and other VSA neurons. Glutamic Acid 49-58 arginine vasopressin Rattus norvegicus 36-39 3857466-4 1985 Bilateral microinjections of kainic acid (50 ng) into the ventrolateral glutamate-sensitive area markedly reduced a vasopressin-induced pressor response to kainic acid (30 ng), injected bilaterally into the nucleus tractus solitarii. Glutamic Acid 72-81 arginine vasopressin Rattus norvegicus 116-127 3567716-0 1987 Modulation by arginine vasopressin of glutamate excitation in the ventral septal area of the rat brain. Glutamic Acid 38-47 arginine vasopressin Rattus norvegicus 23-34 3567716-3 1987 Applied in this manner, vasopressin reduced glutamate-evoked excitation in 32 of the 47 cells studied. Glutamic Acid 44-53 arginine vasopressin Rattus norvegicus 24-35 3567716-6 1987 These observations suggest that vasopressin may be acting on a V1-like receptor on specific neurons in the ventral septal area as a modulator of glutamate actions. Glutamic Acid 145-154 arginine vasopressin Rattus norvegicus 32-43 3857466-5 1985 It is concluded that the glutamate-sensitive neurons in the caudal ventrolateral medulla are involved in mediation of the vasopressin-induced pressor response arising from the nucleus tractus solitarii. Glutamic Acid 25-34 arginine vasopressin Rattus norvegicus 122-133 6149788-2 1984 In the majority of the lateral septal neurons, iontophoretically applied AVP induced a marked increase in the excitatory responses to glutamate, aspartate, quisqualate and N-methyl-D-aspartate. Glutamic Acid 134-143 arginine vasopressin Rattus norvegicus 73-76