PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30155524-2 2018 To investigate co-expression of vesicular GABA transporter (VGAT, a marker of GABA neurons) and the vesicular glutamate transporter-2 (VGLUT2, a marker of glutamate neurons) in orexin and MCH neurons, we generated two transgenic mouse lines. Glutamic Acid 110-119 hypocretin Mus musculus 177-183 31159922-3 2019 However, orexin neurons produce and release orexin as well as several co-transmitters including dynorphin and glutamate. Glutamic Acid 110-119 hypocretin Mus musculus 9-15 30253175-4 2019 Studies in hypothalamic slices from drug-naive animals indicate that agonism of group III metabotropic glutamate receptors (mGluRs) reduces presynaptic glutamate release onto orexin cells. Glutamic Acid 103-112 hypocretin Mus musculus 175-181 30465812-9 2019 Finally, in vivo microdialysis experiments showed that amphetamine potentiated orexin A-induced dopamine and glutamate release in the ventral tegmental area (VTA). Glutamic Acid 109-118 hypocretin Mus musculus 79-87 24951857-2 2014 Past studies have shown the role of the orexin peptide itself; however, orexin neurons contain not only orexin but also other neurotransmitters such as glutamate and dynorphin. Glutamic Acid 152-161 hypocretin Mus musculus 72-78 29315422-2 2018 TBI was speculated to reduce orexin neuronal activity through decreased regional excitatory (glutamate) and/or increased inhibitory (GABA) input. Glutamic Acid 93-102 hypocretin Mus musculus 29-35 29315422-10 2018 Conclusions: These results suggest TBI compromises orexin neuron function via decreased glutamate density and highlight BCAA supplementation as a potential therapy to restore glutamate density to orexin neurons. Glutamic Acid 175-184 hypocretin Mus musculus 196-202 24297328-0 2015 Hypocretin (orexin) regulates glutamate input to fast-spiking interneurons in layer V of the Fr2 region of the murine prefrontal cortex. Glutamic Acid 30-39 hypocretin Mus musculus 0-10 24297328-6 2015 Finally, hypocretin increased the firing frequency in FS cells, and the effect was blocked when the ionotropic glutamate transmission was inhibited. Glutamic Acid 111-120 hypocretin Mus musculus 9-19 24297328-10 2015 We conclude that 1) hypocretin regulates glutamate release in Fr2; 2) the effect presents a presynaptic component; 3) the peptide control of FS cells is indirect, and probably mediated by the regulation of glutamatergic input onto these cells. Glutamic Acid 41-50 hypocretin Mus musculus 20-30 28966976-7 2017 Virtually all MCH and approximately half of the Hcrt/Ox neurons sampled express both the machinery for glutamate release and GABA synthesis in the absence of a vesicular GABA release pathway. Glutamic Acid 103-112 hypocretin Mus musculus 48-52 24951857-2 2014 Past studies have shown the role of the orexin peptide itself; however, orexin neurons contain not only orexin but also other neurotransmitters such as glutamate and dynorphin. Glutamic Acid 152-161 hypocretin Mus musculus 72-78 23959674-10 2013 In addition, these results indicate the possible involvement of glutamate in orexin neurons implicated in PGE2-induced fever. Glutamic Acid 64-73 hypocretin Mus musculus 77-83 25107627-12 2014 Thus, decreased glucose increases orexin-dependent excitatory glutamate neurotransmission onto VTA DA neurons. Glutamic Acid 62-71 hypocretin Mus musculus 34-40 24790280-3 2014 In the PF-LHA, HCRT neurons are intermingled with glutamate-expressing neurons and also co-express glutamate. Glutamic Acid 99-108 hypocretin Mus musculus 15-19 24790280-4 2014 Evidence suggests that HCRT-glutamate interactions within the PF-LHA may play a critical role in maintaining behavioral arousal. Glutamic Acid 28-37 hypocretin Mus musculus 23-27 18551194-6 2008 N/OFQ also modulated presynaptic release of GABA and glutamate onto Hcrt neurons in mouse hypothalamic slices. Glutamic Acid 53-62 hypocretin Mus musculus 68-72 19321767-8 2009 In contrast, TRH significantly reduced the frequency, but not amplitude, of miniature excitatory PSCs without affecting miniature inhibitory PSC frequency or amplitude, indicating that TRH also reduces the probability of glutamate release onto Hcrt neurons. Glutamic Acid 221-230 hypocretin Mus musculus 244-248 19750917-1 2009 STUDY OBJECTIVES: The orexin-producing neurons are hypothesized to be essential for the circadian control of sleep/wake behavior, but it remains unknown whether these rhythms are mediated by the orexin peptides or by other signaling molecules released by these neurons such as glutamate or dynorphin. Glutamic Acid 277-286 hypocretin Mus musculus 22-28 16492946-10 2006 The robust excitation evoked by Hcrt-2 on cortically projecting glutamate PVT neurons could generate substantial excitation in multiple layers of the mPFC, adding to the more selective direct excitatory actions of Hcrt in the mPFC and potentially increasing cortical arousal and attention to limbic or visceral states. Glutamic Acid 64-73 hypocretin Mus musculus 32-36 16492946-10 2006 The robust excitation evoked by Hcrt-2 on cortically projecting glutamate PVT neurons could generate substantial excitation in multiple layers of the mPFC, adding to the more selective direct excitatory actions of Hcrt in the mPFC and potentially increasing cortical arousal and attention to limbic or visceral states. Glutamic Acid 64-73 hypocretin Mus musculus 214-218 12495630-0 2002 Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Glutamic Acid 57-66 hypocretin Mus musculus 0-17 12495630-4 2002 The mechanism for this appears to be hypocretin-mediated excitation of local glutamatergic neurons that regulate hypocretin neuron activity, in part by presynaptic facilitation of glutamate release. Glutamic Acid 77-86 hypocretin Mus musculus 37-47 12495630-4 2002 The mechanism for this appears to be hypocretin-mediated excitation of local glutamatergic neurons that regulate hypocretin neuron activity, in part by presynaptic facilitation of glutamate release. Glutamic Acid 77-86 hypocretin Mus musculus 113-123