PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21158076-0 2006 [Interleukin-6 prevents cultured cerebellar granule neurons from glutamate-induced neurotoxicity]. Glutamic Acid 65-74 interleukin 6 Homo sapiens 1-14 21158076-1 2006 AIM: To explore IL-6 neuroprotection against glutamate-induced neurotoxicity and primary mechanisms involved in this neuroprotection. Glutamic Acid 45-54 interleukin 6 Homo sapiens 16-20 21158076-5 2006 RESULTS: The chronic IL-6 (2.5, 5 and 10 ng/ml) pretreatment of the cultured cerebellar granule neurons remarkably improved the decreased neuronal vitality by glutamate in a concentration-dependent manner. Glutamic Acid 159-168 interleukin 6 Homo sapiens 21-25 21158076-6 2006 The neuronal apoptosis induced by glutamate was significantly attenuated by the chronic IL-6 pretreatment. Glutamic Acid 34-43 interleukin 6 Homo sapiens 88-92 21158076-7 2006 The intracellular Ca2+ overload evoked by glutamate was also inhibited by the chronic IL-6 pretreatment. Glutamic Acid 42-51 interleukin 6 Homo sapiens 86-90 21158076-9 2006 CONCLUSION: IL-6 can protect neurons against glutamate-induced exciting neurotoxicity. Glutamic Acid 45-54 interleukin 6 Homo sapiens 12-16 21158076-10 2006 The mechanism of IL-6 neuroprotection may be closely related to the suppression of glutamate-induced intracellular Ca2+ overload and mediated by gp130 intracellular signal transduction pathways. Glutamic Acid 83-92 interleukin 6 Homo sapiens 17-21 12702735-5 2003 The arterial IL-6 concentration was lower (P < 0.05) after 120 min of exercise in GLU, but neither intramuscular glycogen nor IL-6 mRNA were different when comparing GLU with CON. Glutamic Acid 85-88 interleukin 6 Homo sapiens 13-17 15663961-0 2005 Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity. Glutamic Acid 67-76 interleukin 6 Homo sapiens 0-13 15663961-3 2005 In the present study, we explored protective effect of IL-6 that was chronically applied to cerebellar granule neurons (CGNs) in culture against neurodamage induced by glutamate and mechanisms involved in the neuroprotective effect of IL-6. Glutamic Acid 168-177 interleukin 6 Homo sapiens 55-59 15663961-4 2005 The chronic IL-6 exposure significantly prevented the CGNs from the glutamate-induced attenuation of neuronal vitality. Glutamic Acid 68-77 interleukin 6 Homo sapiens 12-16 15663961-7 2005 The glutamate-evoked neuronal apoptosis also was strikingly inhibited by the chronic IL-6 pretreatment. Glutamic Acid 4-13 interleukin 6 Homo sapiens 85-89 15663961-9 2005 Although intracellular Ca2+ in the IL-6-pretreated CGNs also produced an acute and transient elevation in response to the glutamate insult, they quickly dropped and recovered to basal levels before the glutamate application. Glutamic Acid 122-131 interleukin 6 Homo sapiens 35-39 15663961-9 2005 Although intracellular Ca2+ in the IL-6-pretreated CGNs also produced an acute and transient elevation in response to the glutamate insult, they quickly dropped and recovered to basal levels before the glutamate application. Glutamic Acid 202-211 interleukin 6 Homo sapiens 35-39 15663961-10 2005 Anti-gp130 monoclonal antibody (mAb) blocked the suppressive effect of IL-6 on the glutamate-induced intracellular Ca2+ overload. Glutamic Acid 83-92 interleukin 6 Homo sapiens 71-75 15663961-11 2005 These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. Glutamic Acid 59-68 interleukin 6 Homo sapiens 26-30 15663961-11 2005 These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. Glutamic Acid 59-68 interleukin 6 Homo sapiens 139-143 15663961-11 2005 These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. Glutamic Acid 204-213 interleukin 6 Homo sapiens 26-30 15663961-11 2005 These results reveal that IL-6 can protect neurons against glutamate-induced neurotoxicity, and suggest that the neuroprotective effect of IL-6 may be via gp130 signal transducing pathway to suppress the glutamate-evoked intracellular Ca2+ overload. Glutamic Acid 204-213 interleukin 6 Homo sapiens 139-143 12702735-6 2003 However, net leg IL-6 release was attenuated (P < 0.05) in GLU compared with CON. Glutamic Acid 62-65 interleukin 6 Homo sapiens 17-21 12044971-3 2002 IL6 upregulated the expression of the neuroprotective acidic fibroblast growth factor (aFGF) and reduced the glutamate-induced cytotoxicity. Glutamic Acid 109-118 interleukin 6 Homo sapiens 0-3 34547109-8 2021 Moreover, in MS patients, significant correlations were found between L-Glu and both CSF levels of lactate and the inflammatory molecules interleukin (IL)-2, IL-6, and IL-1 receptor antagonist. Glutamic Acid 70-75 interleukin 6 Homo sapiens 158-162 10485589-9 1999 It is likely that the molecular mechanisms underlying the actions of IL-6 on the HPA axis and its other brain functions involve the integrated effects of glutamate, Ca2+, 3",5"-cyclic AMP, protein kinase C, and other metabolic pathways. Glutamic Acid 154-163 interleukin 6 Homo sapiens 69-73 9672141-0 1998 Influence of L-glutamic acid on binding of interleukin-1beta, tumour necrosis factor-alpha and interleukin-6 to HL-60 cells. Glutamic Acid 13-28 interleukin 6 Homo sapiens 95-108 7913397-1 1994 We examined the effect of interleukin-6 (human recombinant) on glutamate-induced neuronal death of cultured 20-day fetal rat hippocampal neurons. Glutamic Acid 63-72 interleukin 6 Homo sapiens 26-39 9269644-15 1997 Il-6 release: Amino/Bic, 33.0 +/- 6.6%; Glu/Bic, 65.5 +/- 10.3%; Glu/Lac, 1.5 +/- 0.7% referred to RPMI). Glutamic Acid 40-43 interleukin 6 Homo sapiens 0-4 9269644-15 1997 Il-6 release: Amino/Bic, 33.0 +/- 6.6%; Glu/Bic, 65.5 +/- 10.3%; Glu/Lac, 1.5 +/- 0.7% referred to RPMI). Glutamic Acid 65-68 interleukin 6 Homo sapiens 0-4 1558971-1 1992 IL-6-PE4E is a recombinant protein consisting of interleukin-6 (IL-6) fused to a mutant form of Pseudomonas exotoxin in which four basic amino acids are changed to glutamate (PE4E). Glutamic Acid 164-173 interleukin 6 Homo sapiens 0-4 33997590-9 2021 IL-6 showed a significant positive correlation with insulin sensitivity and significant negative correlation with insulin resistance and serum glutamate pyruvate transaminase. Glutamic Acid 143-152 interleukin 6 Homo sapiens 0-4 34075143-9 2021 HREC, which became senescent in the presence of GLU, demonstrated higher expression of genes regulating the synthesis of Il6 and VEGF-A, which was reflected by increased secretion of these cytokines (IL6 + 125%, p < 0.001 vs control and VEGF-A + 124% p < 0.001 vs control). Glutamic Acid 48-51 interleukin 6 Homo sapiens 121-124 34075143-9 2021 HREC, which became senescent in the presence of GLU, demonstrated higher expression of genes regulating the synthesis of Il6 and VEGF-A, which was reflected by increased secretion of these cytokines (IL6 + 125%, p < 0.001 vs control and VEGF-A + 124% p < 0.001 vs control). Glutamic Acid 48-51 interleukin 6 Homo sapiens 200-203 33935833-5 2021 In the 31 adolescents with usable cytokine and Glu data, we found that IL-6 was significantly positively associated with dorsal ACC Glu (beta = 0.466 +- 0.199, p = 0.029). Glutamic Acid 47-50 interleukin 6 Homo sapiens 71-75 33935833-5 2021 In the 31 adolescents with usable cytokine and Glu data, we found that IL-6 was significantly positively associated with dorsal ACC Glu (beta = 0.466 +- 0.199, p = 0.029). Glutamic Acid 132-135 interleukin 6 Homo sapiens 71-75 33935833-6 2021 Of the 16 participants who had usable Asc data, we found that at higher levels of dorsal ACC Asc, there was a negative association between IL-6 and Glu (interaction effect: beta = -0.906 +- 0.433, p = 0.034). Glutamic Acid 148-151 interleukin 6 Homo sapiens 139-143 33277657-11 2021 CONCLUSIONS: Elevated plasma glutamate levels are associated with increased cIMT, independently of established CVD risk factors and this relationship may in part be explained by IL-6-associated subclinical inflammation. Glutamic Acid 29-38 interleukin 6 Homo sapiens 178-182 21651918-13 2011 Moreover, reduction in the levels of IL-6, IL-1Ra, MCP-1/CCL2 and IL-8/CXCL8 was observed in the presence of APE1 Glu allele in BM patients. Glutamic Acid 114-117 interleukin 6 Homo sapiens 37-41 32313211-6 2021 Further, glutamate had extensive effects on gene expression in the mast cells, including the upregulation of pro-inflammatory components such as IL-6 and CCL2. Glutamic Acid 9-18 interleukin 6 Homo sapiens 145-149 23131831-8 2012 Replacement of the IKKgamma/NEMO S377 residue by alanine (S377A) or glutamic acid (S377E) resulted in a significant increase or decrease of NF-kappaB activity and TNF-alpha-mediated IL-6 cytokine production, respectively. Glutamic Acid 68-81 interleukin 6 Homo sapiens 182-186 23226414-2 2012 Biochemical evidence demonstrates that in primary cortical neurons and SH-SY5Y neuroblastoma cells, IL-6 cytokine family members, OSM and IL-6 plus the soluble IL-6R (IL-6/R), prevent NMDA and glutamate-induced neuronal toxicity. Glutamic Acid 193-202 interleukin 6 Homo sapiens 100-104 31102177-7 2020 Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis. Glutamic Acid 0-3 interleukin 6 Homo sapiens 90-94 25986861-1 2015 Oncostatin M (OSM), a cytokine in the interleukin-6 (IL-6) family, has been proposed to play a protective role in the central nervous system, such as attenuation of excitotoxicity induced by N-methyl-D-aspartate (NMDA) and glutamate. Glutamic Acid 223-232 interleukin 6 Homo sapiens 53-57 19061939-3 2009 We previously indicated that exogenous IL-6 protected neurons against glutamate and N-methyl-d-aspartate (NMDA) attacks and the effects of IL-6 was blocked by anti-gp130 antibody. Glutamic Acid 70-79 interleukin 6 Homo sapiens 39-43 20717763-1 2011 We have previously shown that interleukin-6 (IL-6)-protected neurons against the suppression of neuronal vitality and overload of intracellular Ca(2+) induced by glutamate or N-methyl-D: -aspartate (NMDA). Glutamic Acid 162-171 interleukin 6 Homo sapiens 30-43 20717763-1 2011 We have previously shown that interleukin-6 (IL-6)-protected neurons against the suppression of neuronal vitality and overload of intracellular Ca(2+) induced by glutamate or N-methyl-D: -aspartate (NMDA). Glutamic Acid 162-171 interleukin 6 Homo sapiens 45-49 18022595-9 2007 Synthesis of Il-6, vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFbeta), and fibronectin was higher in GLU group as compared with control: + 86%, P < 0.001, +38%, P < 0.05, +51%, P < 0.001, +38%, P < 0.05, respectively. Glutamic Acid 135-138 interleukin 6 Homo sapiens 13-17 18971377-3 2009 Using immunocytochemistry, Western blot, and patch-clamp recording, we demonstrate that H-IL-6 induces the differentiation of neural stem cells (NSCs) specifically into glutamate-responsive neurons and two morphological distinctive astroglia cell types. Glutamic Acid 169-178 interleukin 6 Homo sapiens 90-94 17987062-5 2008 IL-6-induced amplification of A1 receptor function enhances the responses to readily released adenosine during hypoxia, enables neuronal rescue from glutamate-induced death, and protects animals from chemically induced convulsing seizures. Glutamic Acid 149-158 interleukin 6 Homo sapiens 0-4