PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33053951-1 2020 BACKGROUND AND PURPOSE: Liver enzymes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma-glutamyl transpeptidase [GGT]) are glutamate-regulatory enzymes, and higher glutamate levels correlated with worse prognosis of patients with neurotrauma. Glutamic Acid 150-159 solute carrier family 17 member 5 Homo sapiens 39-65 33542926-8 2021 mTORC1 upregulated NF-kappaB activation and the expression of AST and ODC in response to glutamate and ornithine treatments, whereas rapamycin inhibited the utilization of glutamate and ornithine in hepatocytes. Glutamic Acid 89-98 solute carrier family 17 member 5 Homo sapiens 62-65 33053951-1 2020 BACKGROUND AND PURPOSE: Liver enzymes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma-glutamyl transpeptidase [GGT]) are glutamate-regulatory enzymes, and higher glutamate levels correlated with worse prognosis of patients with neurotrauma. Glutamic Acid 191-200 solute carrier family 17 member 5 Homo sapiens 39-65 27051595-2 2016 Although AST and ALT play central roles in glutamate production as transaminases, peripheral blood levels of AST and ALT have been regarded only as liver injury biomarkers. Glutamic Acid 43-52 solute carrier family 17 member 5 Homo sapiens 9-12 27068062-4 2016 In the presence of inhibitor, both malate and glutamate were required to generate a high enough NADH/NAD(+) ratio to support ROS production through the coordinated activity of malate dehydrogenase (MDH) and aspartate aminotransferase (AST). Glutamic Acid 46-55 solute carrier family 17 member 5 Homo sapiens 207-233 27068062-4 2016 In the presence of inhibitor, both malate and glutamate were required to generate a high enough NADH/NAD(+) ratio to support ROS production through the coordinated activity of malate dehydrogenase (MDH) and aspartate aminotransferase (AST). Glutamic Acid 46-55 solute carrier family 17 member 5 Homo sapiens 235-238 27068062-6 2016 With malate alone, oxaloacetate accumulation limited NADH production by MDH unless glutamate was also added to promote oxaloacetate removal via AST. Glutamic Acid 83-92 solute carrier family 17 member 5 Homo sapiens 144-147 27068062-11 2016 We conclude that in mitochondria with inhibited complex I, malate/glutamate-stimulated ROS generation depends strongly on oxaloacetate removal and on the ability of KGDH to oxidize KG generated by AST. Glutamic Acid 66-75 solute carrier family 17 member 5 Homo sapiens 197-200 27051595-8 2016 RESULTS: Both plasma AST and ALT had a significant positive correlation with plasma glutamate levels. Glutamic Acid 84-93 solute carrier family 17 member 5 Homo sapiens 21-24 23377269-15 2012 Elevated concentrations of AST and ALT in plasma reflect the importance of these enzymes in the maintenance of stable blood glutamate concentrations. Glutamic Acid 124-133 solute carrier family 17 member 5 Homo sapiens 27-30 21781115-1 2011 Sialin, the protein coded by SLC17A5, is responsible for membrane potential (Deltapsi)-driven aspartate and glutamate transport into synaptic vesicles in addition to H+/sialic acid co-transport in lysosomes. Glutamic Acid 108-117 solute carrier family 17 member 5 Homo sapiens 0-6 21781115-1 2011 Sialin, the protein coded by SLC17A5, is responsible for membrane potential (Deltapsi)-driven aspartate and glutamate transport into synaptic vesicles in addition to H+/sialic acid co-transport in lysosomes. Glutamic Acid 108-117 solute carrier family 17 member 5 Homo sapiens 29-36 21781115-4 2011 Proteoliposomes containing purified heterologously expressed human sialin exhibited both Deltapsi-driven aspartate and glutamate transport activity and H+/sialic acid co-transport activity. Glutamic Acid 119-128 solute carrier family 17 member 5 Homo sapiens 67-73 21781115-6 2011 In contrast, SLC17A5 protein harboring the mutations associated with infantile sialic acid storage disease, H183R and Delta268SSLRN272 still showed normal levels of Deltapsi-driven aspartate and glutamate transport even though H+/sialic acid co-transport activity was absent. Glutamic Acid 195-204 solute carrier family 17 member 5 Homo sapiens 13-20 21380856-3 2011 Erythrocytic glutamate biosynthesis is catalyzed by three enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutamine aminohydrolase (GA). Glutamic Acid 13-22 solute carrier family 17 member 5 Homo sapiens 99-125 21380856-3 2011 Erythrocytic glutamate biosynthesis is catalyzed by three enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutamine aminohydrolase (GA). Glutamic Acid 13-22 solute carrier family 17 member 5 Homo sapiens 127-130 17270417-8 2007 The proposed l-glutamate biosensor provides adequate sensitivity for the measurement of AST and ALT and is expectable to be applied for rapid blood screening of AST and ALT activity in clinical sample. Glutamic Acid 13-24 solute carrier family 17 member 5 Homo sapiens 88-91 18695252-4 2008 RNA interference of sialin expression decreased exocytosis of aspartate and glutamate in pinealocytes. Glutamic Acid 76-85 solute carrier family 17 member 5 Homo sapiens 20-26 18695252-5 2008 Proteoliposomes containing purified sialin actively accumulated aspartate and glutamate to a similar extent when inside positive membrane potential is imposed as the driving force. Glutamic Acid 78-87 solute carrier family 17 member 5 Homo sapiens 36-42 18695252-6 2008 Sialin carrying a mutation found in people suffering from Salla disease (R39C) was completely devoid of aspartate and glutamate transport activity, although it retained appreciable H(+)/sialic acid cotransport activity. Glutamic Acid 118-127 solute carrier family 17 member 5 Homo sapiens 0-6 17270417-8 2007 The proposed l-glutamate biosensor provides adequate sensitivity for the measurement of AST and ALT and is expectable to be applied for rapid blood screening of AST and ALT activity in clinical sample. Glutamic Acid 13-24 solute carrier family 17 member 5 Homo sapiens 161-164 17045597-1 2006 A new sensitive assay for aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities in biofluids was developed, based on the separation and detection of alanine, glutamate, and aspartate using capillary electrophoresis (CE) with electrochemiluminescence (ECL) detection. Glutamic Acid 183-192 solute carrier family 17 member 5 Homo sapiens 26-52 17045597-1 2006 A new sensitive assay for aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities in biofluids was developed, based on the separation and detection of alanine, glutamate, and aspartate using capillary electrophoresis (CE) with electrochemiluminescence (ECL) detection. Glutamic Acid 183-192 solute carrier family 17 member 5 Homo sapiens 54-57 17045597-3 2006 A mass detection limit of 37.3 fmol (or 81.5 fmol) for glutamate, corresponding to the product in the enzyme reaction catalyzed by 1.24 x 10(-9)U AST (or 2.72 x 10(-9)U ALT) in a 30 min reaction period, was achieved. Glutamic Acid 55-64 solute carrier family 17 member 5 Homo sapiens 146-149 17270417-1 2007 An l-glutamate biosensor modified by cation exchanger membrane on a palladium (Pd) electrode was designed for the purpose of preventing interferences and electrode fouling during the measurement of serum AST and ALT activities. Glutamic Acid 3-14 solute carrier family 17 member 5 Homo sapiens 204-207 15044735-7 2004 This is well illustrated by AST, in which Asp 150 and Glu 221B, despite some distance from the S1 binding site, lower the electrostatic potential of the S1 site and thus enhance substrate binding. Glutamic Acid 54-57 solute carrier family 17 member 5 Homo sapiens 28-31