PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23396537-6 2013 Using mismatched astrocyte and neuron co-cultures, we demonstrate that the loss of astroglial (but not neuronal) FMRP particularly reduces neuron-dependent GLT1 expression and glutamate uptake in co-cultures. Glutamic Acid 176-185 fragile X messenger ribonucleoprotein 1 Mus musculus 113-117 23553633-0 2013 Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion. Glutamic Acid 67-76 fragile X messenger ribonucleoprotein 1 Mus musculus 121-125 23392687-0 2013 A target cell-specific role for presynaptic Fmr1 in regulating glutamate release onto neocortical fast-spiking inhibitory neurons. Glutamic Acid 63-72 fragile X messenger ribonucleoprotein 1 Mus musculus 44-48 23396537-4 2013 We found that astroglial glutamate transporter subtype glutamate transporter 1 (GLT1) and glutamate uptake is significantly reduced in the cortex of fmr1(-/-) mice. Glutamic Acid 25-34 fragile X messenger ribonucleoprotein 1 Mus musculus 149-153 22384253-9 2012 Thus, absence of FMRP may impair the ability of cortical pyramidal neurons to respond to glutamate released from nearby pre-synaptic terminals, which may be a critical step to initiate synaptogenesis and stabilize spines. Glutamic Acid 89-98 fragile X messenger ribonucleoprotein 1 Mus musculus 17-21 16135762-3 2005 We find that in a FXS mouse model, in which the function of FMRP is suppressed, synaptically released glutamate induced prolonged epileptiform discharges resulting from enhanced group I metabotropic glutamate receptor (mGluR)-mediated responses in hippocampal slices. Glutamic Acid 102-111 fragile X messenger ribonucleoprotein 1 Mus musculus 60-64 18028882-4 2008 RESULTS: Our results show that absence of FMRP is associated with apparently normal striatal glutamate-mediated transmission, but abnormal gamma-aminobutyric acid (GABA) transmission. Glutamic Acid 93-102 fragile X messenger ribonucleoprotein 1 Mus musculus 42-46 33949019-2 2021 Electrophysiology studies in Fmr1 knockout (KO) mice, a murine model of Fragile X Syndrome, have demonstrated alterations of synaptic plasticity, with exaggerated long term depression induced by activation of metabotropic glutamate receptors (mGluR-LTD) in Fmr1 KO hippocampus. Glutamic Acid 222-231 fragile X messenger ribonucleoprotein 1 Mus musculus 29-33 32970902-3 2021 Recent evidence suggests that selective loss of astroglial FMRP is able to dysregulate glutamate uptake, increase spine density, and impair motor-skill learning. Glutamic Acid 87-96 fragile X messenger ribonucleoprotein 1 Mus musculus 59-63 31129085-2 2019 We found that the potentiation of glutamate release induced by the beta adrenergic receptor (betaAR) agonist isoproterenol is absent in cerebrocortical nerve terminals (synaptosomes) from mice lacking FMRP (Fmr1 KO), despite the normal cAMP generation. Glutamic Acid 34-43 fragile X messenger ribonucleoprotein 1 Mus musculus 201-205 31129085-2 2019 We found that the potentiation of glutamate release induced by the beta adrenergic receptor (betaAR) agonist isoproterenol is absent in cerebrocortical nerve terminals (synaptosomes) from mice lacking FMRP (Fmr1 KO), despite the normal cAMP generation. Glutamic Acid 34-43 fragile X messenger ribonucleoprotein 1 Mus musculus 207-211 27383586-8 2016 Together, these results show that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS, presumably through dysregulated astroglial glutamate transporter GLT1 and impaired glutamate uptake. Glutamic Acid 165-174 fragile X messenger ribonucleoprotein 1 Mus musculus 67-71 27517961-0 2016 Imbalance between Glutamate and GABA in Fmr1 Knockout Astrocytes Influences Neuronal Development. Glutamic Acid 18-27 fragile X messenger ribonucleoprotein 1 Mus musculus 40-44 27517961-8 2016 This neurotoxicity was triggered by an imbalanced release of glutamate and GABA from Fmr1 KO astrocytes. Glutamic Acid 61-70 fragile X messenger ribonucleoprotein 1 Mus musculus 85-89 27517961-11 2016 Vigabatrin (VGB), a GABA-T inhibitor, reversed the changes caused by glutamate and GABA release in Fmr1 KO astrocytes and the abnormal behaviors in Fmr1 KO mice. Glutamic Acid 69-78 fragile X messenger ribonucleoprotein 1 Mus musculus 99-103 28213518-9 2017 In accordance with this result, deficits in the ability of GABABRs to suppress glutamate release were seen in Fmr1-KO mice. Glutamic Acid 79-88 fragile X messenger ribonucleoprotein 1 Mus musculus 110-114 27383586-12 2016 Our current study generated astrocyte-specific Fmr1 conditional knock-out and restoration mice, and provided compelling evidence that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS, likely through the dysregulated astroglial glutamate transporter GLT1 expression and impaired glutamate uptake. Glutamic Acid 265-274 fragile X messenger ribonucleoprotein 1 Mus musculus 167-171 25568123-4 2015 We now show that glutamate exposure (10 mum for 30 min) reduced FMRP levels in wild-type mouse hippocampal slices. Glutamic Acid 17-26 fragile X messenger ribonucleoprotein 1 Mus musculus 64-68 25568123-8 2015 The results suggest that stimulation of group I mGluRs during glutamate exposure caused proteolysis of FMRP. Glutamic Acid 62-71 fragile X messenger ribonucleoprotein 1 Mus musculus 103-107 26719241-1 2016 Fragile X Mental Retardation Protein (FMRP) is a RNA-binding protein that modulates protein synthesis at the synapse and its function is regulated by glutamate. Glutamic Acid 150-159 fragile X messenger ribonucleoprotein 1 Mus musculus 0-36 26719241-1 2016 Fragile X Mental Retardation Protein (FMRP) is a RNA-binding protein that modulates protein synthesis at the synapse and its function is regulated by glutamate. Glutamic Acid 150-159 fragile X messenger ribonucleoprotein 1 Mus musculus 38-42 26427907-8 2016 Among these presynaptic FMRP functions, FMRP interaction with large-conductance calcium-activated K(+) (BK) channels, specifically their auxiliary beta4 subunit, regulates action potential waveform and glutamate release in hippocampal and cortical pyramidal neurons. Glutamic Acid 202-211 fragile X messenger ribonucleoprotein 1 Mus musculus 24-28 26427907-8 2016 Among these presynaptic FMRP functions, FMRP interaction with large-conductance calcium-activated K(+) (BK) channels, specifically their auxiliary beta4 subunit, regulates action potential waveform and glutamate release in hippocampal and cortical pyramidal neurons. Glutamic Acid 202-211 fragile X messenger ribonucleoprotein 1 Mus musculus 40-44