PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28701926-12 2017 Regional alterations in glutamate secretion can be further driven by PSD95-mediated spatial recruitment of signaling complexes including glutamate receptors and calcium pumps, representing a novel mechanism of psychogenic action of ketamine. Glutamic Acid 24-33 discs large MAGUK scaffold protein 4 Rattus norvegicus 69-74 33420680-12 2021 Similarly, glutamate-mediated increase in acetylcholinesterase expression corroborated downregulation of synaptophysin and PSD-95, coupled with initiation of reactive astrogliosis (GFAP). Glutamic Acid 11-20 discs large MAGUK scaffold protein 4 Rattus norvegicus 123-129 30092246-7 2018 The expression of PSD-95 and Arc/Arg3.1, which play structural and functional roles in glutamate neurons, was also similarly reduced. Glutamic Acid 87-96 discs large MAGUK scaffold protein 4 Rattus norvegicus 18-24 28701926-0 2017 Glutamate Deregulation in Ketamine-Induced Psychosis-A Potential Role of PSD95, NMDA Receptor and PMCA Interaction. Glutamic Acid 0-9 discs large MAGUK scaffold protein 4 Rattus norvegicus 73-78 34884781-6 2021 Furthermore, in the hippocampi of KA rats, enmein increased the expression of synaptic markers (synaptophysin and postsynaptic density protein 95) and excitatory amino acid transporters 2 and 3, which are responsible for glutamate clearance, whereas enmein decreased the expression of glial fibrillary acidic protein (GFAP) and CD11b. Glutamic Acid 221-230 discs large MAGUK scaffold protein 4 Rattus norvegicus 114-145 34206065-8 2021 Moreover, exogenous glutamate also reduced the expression of synaptic markers (PSD-95, SYP) and induced apoptotic neurodegeneration in the cortical and hippocampal regions by dysregulating the expression of Bax, Bcl-2 and caspase-3 in the developing rat brain. Glutamic Acid 20-29 discs large MAGUK scaffold protein 4 Rattus norvegicus 79-85 24350898-0 2014 Melatonin improves neuroplasticity by upregulating the growth-associated protein-43 (GAP-43) and NMDAR postsynaptic density-95 (PSD-95) proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to transient focal cerebral ischemia even during a long-term recovery period. Glutamic Acid 176-185 discs large MAGUK scaffold protein 4 Rattus norvegicus 128-134 22218046-10 2011 PSD95 gene silencing enhanced neuronal tolerance against the glutamate excitotoxicity, meanwhile the phosphorylation of CaMKIIalpha Thr286 was attenuated. Glutamic Acid 61-70 discs large MAGUK scaffold protein 4 Rattus norvegicus 0-5 22031893-6 2011 Using an in vitro model of glutamate-induced toxicity in rat hippocampal cultures, we found that cypin overexpression or PSD-95 knockdown increases the percentage of neurons with varicosities and the number of varicosities along dendrites, decreases the size of varicosities after sublethal NMDA exposure, and protects neurons from NMDA-induced death. Glutamic Acid 27-36 discs large MAGUK scaffold protein 4 Rattus norvegicus 121-127 18721130-8 2009 In cultured hippocampal neurons, overexpression of PSD-95 Y523F, but not PSD-95 Y533F, abolishes the facilitating effect of PSD-95 on the glutamate- or NMDA-mediated currents, implying that PSD-95 Tyr(523) phosphorylation contributes to the post-ischaemic over-activation of NMDA receptors. Glutamic Acid 138-147 discs large MAGUK scaffold protein 4 Rattus norvegicus 51-57 21102461-5 2010 Disrupting nNOS-PSD-95 interaction via overexpressing the N-terminal amino acid residues 1-133 of nNOS (nNOS-N(1-133)) prevented glutamate-induced excitotoxicity and cerebral ischemic damage. Glutamic Acid 129-138 discs large MAGUK scaffold protein 4 Rattus norvegicus 16-22 18248606-8 2008 We hypothesize that the GLT1b/PSD-95 interaction, characterized here in vitro, might anchor this transporter close to the post-synaptic glutamate receptors, thereby permitting the fine regulation of glutamate concentrations in this microenvironment. Glutamic Acid 136-145 discs large MAGUK scaffold protein 4 Rattus norvegicus 30-36 17944868-9 2008 Cells expressing p14ARF, which inhibits ubiquitination of post-synaptic density protein 95 and prevents loss of synaptic sites, displayed an increased sensitivity to glutamate-induced cell death. Glutamic Acid 166-175 discs large MAGUK scaffold protein 4 Rattus norvegicus 58-90