PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19526286-0 2009 Polychlorinated biphenyls PCB 153 and PCB 126 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. Glutamic Acid 57-66 pyruvate carboxylase Homo sapiens 26-29 20297801-0 2010 Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. Glutamic Acid 66-75 pyruvate carboxylase Homo sapiens 26-29 20297801-0 2010 Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. Glutamic Acid 66-75 pyruvate carboxylase Homo sapiens 34-37 20297801-0 2010 Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. Glutamic Acid 66-75 pyruvate carboxylase Homo sapiens 34-37 20297801-3 2010 It has been proposed that PCB-induced cognitive impairment is due to impairment of the glutamate-nitric oxide (NO)-cGMP pathway. Glutamic Acid 87-96 pyruvate carboxylase Homo sapiens 26-29 19526286-0 2009 Polychlorinated biphenyls PCB 153 and PCB 126 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. Glutamic Acid 57-66 pyruvate carboxylase Homo sapiens 38-41 19526286-3 2009 Perinatal exposure to PCB 153 or PCB 126 impairs the glutamate-nitric oxide-cGMP pathway in cerebellum in vivo and learning ability in adult rats. Glutamic Acid 53-62 pyruvate carboxylase Homo sapiens 22-25 19526286-3 2009 Perinatal exposure to PCB 153 or PCB 126 impairs the glutamate-nitric oxide-cGMP pathway in cerebellum in vivo and learning ability in adult rats. Glutamic Acid 53-62 pyruvate carboxylase Homo sapiens 33-36 19526286-4 2009 The aims of this work were: (1) to assess whether long-term exposure of primary cultures of cerebellar neurons to PCB 153 or PCB 126 reproduces the impairment in the function of the glutamate-nitric oxide-cGMP pathway found in rat cerebellum in vivo; (2) to provide some insight on the steps of the pathway affected by these PCBs; (3) to assess whether the mechanisms of interference of the pathway are different for PCB 126 and PCB 153. Glutamic Acid 182-191 pyruvate carboxylase Homo sapiens 114-117 19526286-4 2009 The aims of this work were: (1) to assess whether long-term exposure of primary cultures of cerebellar neurons to PCB 153 or PCB 126 reproduces the impairment in the function of the glutamate-nitric oxide-cGMP pathway found in rat cerebellum in vivo; (2) to provide some insight on the steps of the pathway affected by these PCBs; (3) to assess whether the mechanisms of interference of the pathway are different for PCB 126 and PCB 153. Glutamic Acid 182-191 pyruvate carboxylase Homo sapiens 125-128 19526286-4 2009 The aims of this work were: (1) to assess whether long-term exposure of primary cultures of cerebellar neurons to PCB 153 or PCB 126 reproduces the impairment in the function of the glutamate-nitric oxide-cGMP pathway found in rat cerebellum in vivo; (2) to provide some insight on the steps of the pathway affected by these PCBs; (3) to assess whether the mechanisms of interference of the pathway are different for PCB 126 and PCB 153. Glutamic Acid 182-191 pyruvate carboxylase Homo sapiens 125-128 19526286-4 2009 The aims of this work were: (1) to assess whether long-term exposure of primary cultures of cerebellar neurons to PCB 153 or PCB 126 reproduces the impairment in the function of the glutamate-nitric oxide-cGMP pathway found in rat cerebellum in vivo; (2) to provide some insight on the steps of the pathway affected by these PCBs; (3) to assess whether the mechanisms of interference of the pathway are different for PCB 126 and PCB 153. Glutamic Acid 182-191 pyruvate carboxylase Homo sapiens 125-128 19526286-8 2009 Also both PCBs impair the function of the glutamate-nitric oxide-cGMP pathway by different mechanisms, PCB 153 impairs nitric oxide-induced activation of soluble guanylate cyclase and increase in cGMP while PCB 126 does not. Glutamic Acid 42-51 pyruvate carboxylase Homo sapiens 10-13 19526286-8 2009 Also both PCBs impair the function of the glutamate-nitric oxide-cGMP pathway by different mechanisms, PCB 153 impairs nitric oxide-induced activation of soluble guanylate cyclase and increase in cGMP while PCB 126 does not. Glutamic Acid 42-51 pyruvate carboxylase Homo sapiens 103-106 16835632-4 2007 Astrocyte-selective expression of pyruvate carboxylase (PC) enables synthesis of glutamate from glucose, accounting for two-thirds of astrocytic glucose degradation via combined pyruvate carboxylation and dehydrogenation. Glutamic Acid 81-90 pyruvate carboxylase Homo sapiens 34-54 18093177-11 2008 The impairment of the glutamate-NO-cGMP pathway function induced at young age by developmental exposure to the PCBs could be one of the mechanisms contributing to the cognitive impairment found in children whose mothers ingested PCB-contaminated food during pregnancy and lactation. Glutamic Acid 22-31 pyruvate carboxylase Homo sapiens 111-114 10736368-2 2000 This is because glutamate is in isotopic equilibrium with alpha-ketoglutarate, whose labeling pattern is influenced by the following: 1) the contributions of glucose and fatty acids to acetyl-CoA, 2) the relative contributions of pyruvate carboxylase and pyruvate dehydrogenase to the entry of pyruvate carbon into the citric acid cycle, and 3) the rate of gluconeogenesis in relation to citric acid cycle activity. Glutamic Acid 16-25 pyruvate carboxylase Homo sapiens 230-250 16359766-7 2006 Interestingly, pyruvate carboxylase and pyruvate dehydrogenase flux ratios measured by glutamate isotopomers and the production of isotopomers of several metabolites showed that the metabolic processes described could not take place simultaneously in the same macrocompartments (cells). Glutamic Acid 87-96 pyruvate carboxylase Homo sapiens 15-35 16505973-7 2006 In astrocytes, PC is important for de novo synthesis of glutamate, an important excitatory neurotransmitter supplied to neurons. Glutamic Acid 56-65 pyruvate carboxylase Homo sapiens 15-17 10736368-6 2000 In diabetic patients infused with [3-(13)C]pyruvate, the noninvasive sampling of hepatic glutamate via phenylacetylglutamine allows one to test the degree of liver insulinization via the (pyruvate carboxylase)/(pyruvate dehydrogenase) activity ratio. Glutamic Acid 89-98 pyruvate carboxylase Homo sapiens 188-208 33621827-6 2021 Glutamate transporters, pyruvate carboxylase and glutamine synthetase are involved in maintaining the physiological concentration of glutamate in the inter synaptic spaces. Glutamic Acid 133-142 pyruvate carboxylase Homo sapiens 24-44 34220417-3 2021 This requires a continuous de novo synthesis of glutamate, likely involving the action of both pyruvate carboxylase (PC) and glutamate dehydrogenase (GDH). Glutamic Acid 48-57 pyruvate carboxylase Homo sapiens 95-115 7805591-3 1993 The key reason that an interaction with astrocytes is essential is that both pyruvate carboxylase, the major enzyme in the brain for net synthesis of tricarboxylic acid cycle intermediates, and glutamine synthetase, the enzyme forming glutamine from glutamate, are specifically located in astrocytes, but not in neurons. Glutamic Acid 250-259 pyruvate carboxylase Homo sapiens 77-97 3884090-1 1985 Pyruvate carboxylase is the predominant anaplerotic enzyme in CNS tissues, and thus provides for net utilization of glucose to generate citric acid cycle intermediates such as alpha-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, GABA and aspartate. Glutamic Acid 258-267 pyruvate carboxylase Homo sapiens 0-20 34057673-2 2021 Astrocytes synthesize glutamate de novo owing to the pyruvate entry to the citric/tricarboxylic acid cycle via pyruvate carboxylase, an astrocyte specific enzyme. Glutamic Acid 22-31 pyruvate carboxylase Homo sapiens 111-131 33828523-2 2021 Exclusive expression of pyruvate carboxylase and glutamine synthetase in astrocytes positions astrocytes as essential regulators of glutamate in the central nervous system (CNS). Glutamic Acid 132-141 pyruvate carboxylase Homo sapiens 24-44 33708149-0 2021 Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis. Glutamic Acid 15-24 pyruvate carboxylase Homo sapiens 56-76 33708149-2 2021 We propose that the elevated glutamate levels in bipolar disorder can be explained by increased pyruvate carboxylase-mediated anaplerosis in brain. Glutamic Acid 29-38 pyruvate carboxylase Homo sapiens 96-116 29378296-4 2019 Among these enzymes, pyruvate carboxylase and glutamine synthetase are selectively expressed in astrocytes and thus these cells are obligatory partners in synaptic replenishment of both glutamate and GABA. Glutamic Acid 186-195 pyruvate carboxylase Homo sapiens 21-41