PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25723475-10 2015 The protein and mRNA levels of HIF-1alpha, VEGF and TGF-beta1 increased significantly in group GLU, and decreased significantly after administration of LMWH in a dose-dependent manner. Glutamic Acid 95-98 vascular endothelial growth factor A Rattus norvegicus 43-47 26386664-3 2015 In this study, we investigated the effect of glutamate on the proliferation of rat embryonic neural stem/progenitor cells (NSCs) through regulating the vascular endothelial growth factor (VEGF) expression of astrocytes (ASTs) in vitro, and the cyclin D1 expression of NSCs. Glutamic Acid 45-54 vascular endothelial growth factor A Rattus norvegicus 152-186 26386664-3 2015 In this study, we investigated the effect of glutamate on the proliferation of rat embryonic neural stem/progenitor cells (NSCs) through regulating the vascular endothelial growth factor (VEGF) expression of astrocytes (ASTs) in vitro, and the cyclin D1 expression of NSCs. Glutamic Acid 45-54 vascular endothelial growth factor A Rattus norvegicus 188-192 26386664-4 2015 The results showed that glutamate promoted the expression and secretion of VEGF of rat astrocytes by activating group I mGluRs. Glutamic Acid 24-33 vascular endothelial growth factor A Rattus norvegicus 75-79 26386664-8 2015 These results demonstrated that glutamate could also indirectly promote the proliferation of rat embryonic NSCs through inducing the VEGF expression of ASTs in vitro, and VEGF may increase the expression of cyclin D1. Glutamic Acid 32-41 vascular endothelial growth factor A Rattus norvegicus 133-137 26386664-0 2015 Glutamate promotes neural stem cell proliferation by increasing the expression of vascular endothelial growth factor of astrocytes in vitro. Glutamic Acid 0-9 vascular endothelial growth factor A Rattus norvegicus 82-116 21293297-6 2011 These results suggest that increased VEGF and NO production in hypoxia resulted in increased vascular permeability, which, along with increased levels of glutamate, may have induced structural alterations of the neurons, dendrites, and axons. Glutamic Acid 154-163 vascular endothelial growth factor A Rattus norvegicus 37-41 23707263-10 2013 In addition, l-Glutamate and NH4Cl significantly reduced VEGF secretion. Glutamic Acid 13-24 vascular endothelial growth factor A Rattus norvegicus 57-61 21938552-4 2012 VEGF was shown to inhibit hypoosmotic swelling of rat Muller cells by inducing the release of glutamate (Wurm et al. Glutamic Acid 94-103 vascular endothelial growth factor A Rattus norvegicus 0-4 21807419-3 2011 In addition, VEGF expression was increased in neurons and over-expressed in glial cells in a model of neuroexcitotoxicity in the hippocampus, in which rats were neonatally exposed to high glutamate concentrations. Glutamic Acid 188-197 vascular endothelial growth factor A Rattus norvegicus 13-17 21575684-2 2011 It has been shown that vascular endothelial growth factor (VEGF) induces a Ca2+-dependent release of glutamate from the cells [Wurm et al. Glutamic Acid 101-110 vascular endothelial growth factor A Rattus norvegicus 23-57 21575684-2 2011 It has been shown that vascular endothelial growth factor (VEGF) induces a Ca2+-dependent release of glutamate from the cells [Wurm et al. Glutamic Acid 101-110 vascular endothelial growth factor A Rattus norvegicus 59-63 21575684-5 2011 We found that the inhibitory effect of VEGF on the osmotic swelling of retinal glial cells, used as an indicator of glutamate release, is prevented in the presence of selective blockers of T-type VGCCs (kurtoxin, mibefradil, Ni2+) and Na(v) channels (TTX, saxitoxin, phenytoin). Glutamic Acid 116-125 vascular endothelial growth factor A Rattus norvegicus 39-43 20335103-0 2010 [Effect of glutamate on vascular endothelial growth factor mRNA and protein expressions in hypoxic rat astrocytes in vitro]. Glutamic Acid 11-20 vascular endothelial growth factor A Rattus norvegicus 24-58 20335103-1 2010 OBJECTIVE: To study the effect of glutamate on the expression of vascular endothelial growth factor (VEGF) mRNA and protein in cultured rat astrocytes under hypoxia. Glutamic Acid 34-43 vascular endothelial growth factor A Rattus norvegicus 65-99 20335103-1 2010 OBJECTIVE: To study the effect of glutamate on the expression of vascular endothelial growth factor (VEGF) mRNA and protein in cultured rat astrocytes under hypoxia. Glutamic Acid 34-43 vascular endothelial growth factor A Rattus norvegicus 101-105 20335103-5 2010 RESULTS: The expressions of VEGF mRNA and protein underwent no significant changes in the control glutamate groups, but increased obviously in both hypoxia and hypoxia+glutamate groups at 2, 4, 6, 8 and 12 h of hypoxic exposure. Glutamic Acid 98-107 vascular endothelial growth factor A Rattus norvegicus 28-32 20335103-5 2010 RESULTS: The expressions of VEGF mRNA and protein underwent no significant changes in the control glutamate groups, but increased obviously in both hypoxia and hypoxia+glutamate groups at 2, 4, 6, 8 and 12 h of hypoxic exposure. Glutamic Acid 168-177 vascular endothelial growth factor A Rattus norvegicus 28-32 20335103-6 2010 At these time points, VEGF expressions at both the mRNA and protein levels were significantly higher in hypoxia+glutamate group than in hypoxia group. Glutamic Acid 112-121 vascular endothelial growth factor A Rattus norvegicus 22-26 20335103-7 2010 CONCLUSION: Glutamate at 1 micromol/L can further increase the expression of VEGF mRNA and protein in astrocytes exposed to hypoxia, which may result from the adaptive changes of glutamate receptors in hypoxic astrocytes. Glutamic Acid 12-21 vascular endothelial growth factor A Rattus norvegicus 77-81 18803284-6 2009 The results obtained from the Fluo-3 image experiments showed that VEGF pretreatment of cultured neurons at a final concentration of 50, 100, or 200 ng/ml acutely and dose dependently attenuated the Ca(2+) influx induced by application of KCl (60 mM) or glutamate (50 microM). Glutamic Acid 254-263 vascular endothelial growth factor A Rattus norvegicus 67-71 18182045-0 2008 Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase. Glutamic Acid 76-85 vascular endothelial growth factor A Rattus norvegicus 0-34 18182045-9 2008 Together, these findings indicate that VEGF has neuroprotective effects in rat spinal cord against chronic glutamate excitotoxicity by activating the PI3-K/Akt signal transduction pathway and also reinforce the hypothesis of the potential therapeutic effects of VEGF in the prevention of motoneuron degeneration in human ALS. Glutamic Acid 107-116 vascular endothelial growth factor A Rattus norvegicus 39-43