PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11008167-4 2000 To study the seizure-induced activation of glutamate decarboxylase, we investigated the expression of both embryonic and adult glutamate decarboxylase messenger RNAs in the adult rat hippocampus after kainic acid administration by semi-quantitative reverse transcription-coupled polymerase chain reaction, in situ hybridization and immunoblotting. Kainic Acid 201-212 glutamate-ammonia ligase Rattus norvegicus 127-150 11008167-6 2000 The expression of embryonic glutamate decarboxylase transcripts, identified here as the splice variant that contains exon 7/B, peaked at about 2h after kainic acid injection and gradually returned to nearly basal levels by 24h. Kainic Acid 152-163 glutamate-ammonia ligase Rattus norvegicus 28-51 11008167-11 2000 Expression of the messenger RNA encoding for an alternatively spliced, truncated form of the GABA-synthesizing enzyme glutamate decarboxylase was detected in dentate granule cells briefly after kainic acid-induced seizures. Kainic Acid 194-205 glutamate-ammonia ligase Rattus norvegicus 118-141 2141673-1 1990 Pretreatment of rats with 8-16 mg/kg of lamotrigine 1 h before intrastriatal injections of 2 nm of kainic acid significantly attenuated the neurotoxicity as evidenced by measurements of striatal choline acetyltransferase and glutamate decarboxylase activities. Kainic Acid 99-110 glutamate-ammonia ligase Rattus norvegicus 225-248 8848104-8 1995 Kainate injections in the striatum resulted in loss of choline acetyltransferase- and glutamate decarboxylase-like immunoreactive cell bodies in this area. Kainic Acid 0-7 glutamate-ammonia ligase Rattus norvegicus 86-109 8738374-0 1996 An immunocytochemical study of glutamate receptors and glutamine synthetase in the hippocampus of rats injected with kainate. Kainic Acid 117-124 glutamate-ammonia ligase Rattus norvegicus 55-75 7570642-1 1995 Incubation of coronal slices of rat brain with neurotoxic concentrations of kainate (300 microM) and N-methyl-D-aspartate (NMDA; 500 microM) for 40 min reduced the activity of the glial enzyme, glutamine synthetase, by 33% and 21%, respectively. Kainic Acid 76-83 glutamate-ammonia ligase Rattus norvegicus 194-214 1347781-2 1992 First, unilateral intrastriatal microinjection of the excitotoxin kainic acid (2 micrograms in 1 microliter) was shown to evoke vigorous contraversive circling, followed 1 or 2 weeks later by profound decreases in striatal AChE (24 and 54%), GAD (51 and 75%), and protein (36 and 47%), as well as loss of GAD (45% at 2 weeks) in the ipsilateral substantia nigra. Kainic Acid 66-77 glutamate-ammonia ligase Rattus norvegicus 242-245 1347781-2 1992 First, unilateral intrastriatal microinjection of the excitotoxin kainic acid (2 micrograms in 1 microliter) was shown to evoke vigorous contraversive circling, followed 1 or 2 weeks later by profound decreases in striatal AChE (24 and 54%), GAD (51 and 75%), and protein (36 and 47%), as well as loss of GAD (45% at 2 weeks) in the ipsilateral substantia nigra. Kainic Acid 66-77 glutamate-ammonia ligase Rattus norvegicus 305-308 1970631-0 1990 Intrahippocampal kainic acid reduces glutamine synthetase. Kainic Acid 17-28 glutamate-ammonia ligase Rattus norvegicus 37-57 1970631-2 1990 Glutamine synthetase was reduced by 38%, 24 h after the stereotaxic application of 4 nmol of kainic acid to this region. Kainic Acid 93-104 glutamate-ammonia ligase Rattus norvegicus 0-20 1970631-3 1990 The reduction in glutamine synthetase by kainic acid was not due to direct inhibition of the brain enzyme. Kainic Acid 41-52 glutamate-ammonia ligase Rattus norvegicus 17-37 1970631-6 1990 The effect of intrahippocampal kainic acid on glutamine synthetase appears to be indirect, most likely produced secondarily to its neuronal effects. Kainic Acid 31-42 glutamate-ammonia ligase Rattus norvegicus 46-66 1970631-8 1990 A reduction in glutamine synthetase by kainic acid may impair the capacity for astrocytes to metabolize glutamate. Kainic Acid 39-50 glutamate-ammonia ligase Rattus norvegicus 15-35 2902535-4 1988 Significantly increased levels of somatostatin (by 60%), neuropeptide Y (135%) and increased activity of glutamate decarboxylase (22%) were found in the frontal cortex of rats previously treated with kainic acid. Kainic Acid 200-211 glutamate-ammonia ligase Rattus norvegicus 105-128 2902535-6 1988 Michaelis-Menten kinetics of glutamate decarboxylase revealed an increased maximal velocity (Vmax) in the frontal cortex of kainic acid-treated rats, but no change in the Km value was found. Kainic Acid 124-135 glutamate-ammonia ligase Rattus norvegicus 29-52 2448011-6 1987 In contrast, the level of glutamine synthetase (an enzyme localized to glia) mRNA was increased approximately 290% in the kainic acid-lesioned striatum. Kainic Acid 122-133 glutamate-ammonia ligase Rattus norvegicus 26-46 3114666-5 1987 Similarly loss of glutamate decarboxylase activity in dorsal hippocampus induced by kainic acid was prevented by mannitol treatment. Kainic Acid 84-95 glutamate-ammonia ligase Rattus norvegicus 18-41 3626200-3 1987 After a unilateral injection of kainic acid into the right ventral globus pallidus, the GAD levels remained unaffected, but the CAT levels decreased to 63.4% after 7 days. Kainic Acid 32-43 glutamate-ammonia ligase Rattus norvegicus 88-91 20492920-0 1985 Activities of glutamine synthetase, glutaminase and arginase in kainic acid lesioned rat brain corpus striatum. Kainic Acid 64-75 glutamate-ammonia ligase Rattus norvegicus 14-34 20492920-1 1985 Intrastriatal kainic acid (2 ?g/?l) administration gave rise to significant increase in activities of glutamine synthetase and arginase along with a significant decrease in the activity of glutaminase in the lesioned striatal tissue 7 days after the administration of kainic acid. Kainic Acid 14-25 glutamate-ammonia ligase Rattus norvegicus 102-122 6144364-1 1984 Injections of kainic acid into the rostral pontine tegmentum in rats caused not only local lesions but destruction of GABAergic and dopaminergic cells in the substantia nigra (SN), as indicated histologically and by measurements of tyrosine hydroxylase (TH) and glutamate decarboxylase (GAD). Kainic Acid 14-25 glutamate-ammonia ligase Rattus norvegicus 262-285 6144364-1 1984 Injections of kainic acid into the rostral pontine tegmentum in rats caused not only local lesions but destruction of GABAergic and dopaminergic cells in the substantia nigra (SN), as indicated histologically and by measurements of tyrosine hydroxylase (TH) and glutamate decarboxylase (GAD). Kainic Acid 14-25 glutamate-ammonia ligase Rattus norvegicus 287-290 7024401-0 1981 Decrease of glutamate decarboxylase (GAD)-immunoreactive nerve terminals in the substantia nigra after kainic acid lesion of the striatum. Kainic Acid 103-114 glutamate-ammonia ligase Rattus norvegicus 12-35 7024401-0 1981 Decrease of glutamate decarboxylase (GAD)-immunoreactive nerve terminals in the substantia nigra after kainic acid lesion of the striatum. Kainic Acid 103-114 glutamate-ammonia ligase Rattus norvegicus 37-40 7024401-3 1981 Seven days after the injection of 1 microgram kainic acid into the striatum, a 65% decrease in GAD-enzyme activity occurred in the ipsilateral SN. Kainic Acid 46-57 glutamate-ammonia ligase Rattus norvegicus 95-98 6125916-3 1982 In the piriform cortex and amygdaloid complex, the kainic acid lesion was accompanied by a reduction in the high affinity uptake of glutamate and in the activities of glutamate decarboxylase and choline acetyltransferase, whereas in the hippocampus there was a reduction in the high affinity uptake of glutamate and in glutamate decarboxylase activity. Kainic Acid 51-62 glutamate-ammonia ligase Rattus norvegicus 167-190 6125916-3 1982 In the piriform cortex and amygdaloid complex, the kainic acid lesion was accompanied by a reduction in the high affinity uptake of glutamate and in the activities of glutamate decarboxylase and choline acetyltransferase, whereas in the hippocampus there was a reduction in the high affinity uptake of glutamate and in glutamate decarboxylase activity. Kainic Acid 51-62 glutamate-ammonia ligase Rattus norvegicus 319-342