PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16216697-7 2005 DR significantly enhanced the expression of HSP 70 in kainic acid (KA)-treated rats, whereas KA treatment of ad libitum fed rats resulted in decreased HSP 70 expression. Kainic Acid 54-65 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 44-50 19777341-5 2010 Heat-shock protein 70 (Hsp70) immunopositive cells were also observed in the ipsilateral dentate gyrus (DG) following kainic acid injection. Kainic Acid 118-129 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 0-21 19777341-5 2010 Heat-shock protein 70 (Hsp70) immunopositive cells were also observed in the ipsilateral dentate gyrus (DG) following kainic acid injection. Kainic Acid 118-129 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 23-28 16216697-8 2005 The DR was observed to exert neuroprotection by enhancing the expression of HSP 70 in kainic acid treated rats. Kainic Acid 86-97 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 76-82 14580286-0 2003 Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures. Kainic Acid 130-141 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 22-43 11018788-0 2000 Metyrapone, an inhibitor of corticosterone synthesis, blocks the kainic acid-induced expression of HSP 70. Kainic Acid 65-76 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 99-105 11018788-4 2000 Despite the fact that metyrapone blocked/attenuated the kainic acid-evoked induction of HSP 70, its administration did not affect the behavioral effects of kainic acid, regarded as "limbic status epilepticus." Kainic Acid 56-67 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 88-94 11018788-1 2000 It is shown in the present study that metyrapone (100 mg/kg), an inhibitor of corticosterone synthesis, given twice, 30 min before and 6 h after kainic acid (10 mg/kg) administration, blocks the kainic acid-evoked induction of heat shock proteins 72 kDa (HSP 70). Kainic Acid 195-206 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 255-261 11018788-2 2000 Specifically, it was observed that metyrapone completely prevented kainic acid-induced appearance of HSP 70 in the rat amygdala, habenula, parietal cortex, and significantly decreased the number of HSP 70-positive neurons in the CA1, CA3, and CA4 subregions of hippocampus. Kainic Acid 67-78 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 101-107 11018788-2 2000 Specifically, it was observed that metyrapone completely prevented kainic acid-induced appearance of HSP 70 in the rat amygdala, habenula, parietal cortex, and significantly decreased the number of HSP 70-positive neurons in the CA1, CA3, and CA4 subregions of hippocampus. Kainic Acid 67-78 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 198-204 11018788-3 2000 The reduction in HSP 70 induction was paralleled by a complete prevention of the kainic acid-induced rise in the circulating corticosterone level by metyrapone; however, in applied doses metyrapone evoked slight enhancement of blood corticosterone. Kainic Acid 81-92 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 17-23 10521581-0 1999 Cell specific expression of Hsp70 in neurons and glia of the rat hippocampus after hyperthermia and kainic acid-induced seizure activity. Kainic Acid 100-111 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 28-33 10521581-1 1999 In this study we investigated the time course, cell-type and stress-specific expression of hsp70 mRNA and Hsp70 protein in glial cells and neurons in the rat brain following heat shock treatment and kainic acid-induced status epilepticus. Kainic Acid 199-210 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 91-96 10521581-2 1999 Transcripts for hsp70 were detected in hippocampal homogenates from 1.5 to 6 h following hyperthermia and from 3 to 24 h following kainic acid-induced seizures. Kainic Acid 131-142 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 16-21 10521581-3 1999 In situ hybridization revealed hsp70 mRNA to be region specific and time-dependent following hyperthermia and kainic acid-induced seizures. Kainic Acid 110-121 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 31-36 10521581-4 1999 Western analysis indicated that Hsp70 reached maximal levels at 3 h after hyperthermia and 12 h after kainic acid-induced seizures. Kainic Acid 102-113 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 32-37 10521581-8 1999 In contrast, high levels of Hsp70 protein were detected in neurons of the pyramidal cell layer and dentate hilus at 24 h after seizure-inducing kainic acid injection. Kainic Acid 144-155 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 28-33 8848100-1 1995 Induction of heat-shock protein-70 was studied using in situ hybridization and immunohistochemistry in the adult rat at different times following intraperitoneal injection of kainate. Kainic Acid 175-182 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 13-34 9757041-10 1998 The present study suggest that the behavioral changes (seizure intensity and body temperature) and neuropathological damage after systemic administration of kainic acid are inconsistent between animals, and that these behavioral changes (severity of kainic acid-induced limbic seizures) might be correlated with gene expression of hsp-70 mRNA, COX-2 mRNA, and BDNF mRNA in rat brain. Kainic Acid 157-168 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 331-337 9757041-10 1998 The present study suggest that the behavioral changes (seizure intensity and body temperature) and neuropathological damage after systemic administration of kainic acid are inconsistent between animals, and that these behavioral changes (severity of kainic acid-induced limbic seizures) might be correlated with gene expression of hsp-70 mRNA, COX-2 mRNA, and BDNF mRNA in rat brain. Kainic Acid 250-261 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 331-337 9252233-0 1997 Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid. Kainic Acid 137-148 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 51-56 9252233-4 1997 At 6 h after kainic acid, some co-localization of Hsp70 with c-Fos and cyclooxygenase-2 was seen in pyramidal hippocampal neurons and superficial cortical layers, however by 24 h such colocalization became rare within the cortex but was partially maintained in the hippocampus. Kainic Acid 13-24 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 50-55 8758950-1 1996 The effect of MK-801, a non-competitive N-methyl-D-aspartate (NMDA) antagonist, on the kainic acid-induced expression of the inducible heat shock protein 70 kDa (HSP70) and on neuronal death in the rat hippocampus was investigated. Kainic Acid 87-98 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 135-160 8758950-1 1996 The effect of MK-801, a non-competitive N-methyl-D-aspartate (NMDA) antagonist, on the kainic acid-induced expression of the inducible heat shock protein 70 kDa (HSP70) and on neuronal death in the rat hippocampus was investigated. Kainic Acid 87-98 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 162-167 8758950-2 1996 HSP70 is expressed in approximately 80% of the pyramidal neurons in the CA1 field 1 day after kainic acid injection. Kainic Acid 94-105 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 0-5 8758950-3 1996 The majority of these HSP70-immunopositive neurons exhibited swelling and a hollow appearance in the perikaryon, indicating that they had been injured following kainic acid-elicited limbic seizures. Kainic Acid 161-172 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 22-27 8758950-10 1996 When a single dose of MK-801 was given 4 h after kainic acid treatment, HSP70 expression was partially blocked; 18% of neurons expressed HSP70 on day 1 and 37% on day 4 in CA1 pyramidal neurons in comparison to the kainic acid controls. Kainic Acid 49-60 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 72-77 10386975-0 1999 Responses of heat shock proteins hsp27, alphaB-crystallin, and hsp70 in rat brain after kainic acid-induced seizure activity. Kainic Acid 88-99 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 63-68 9153582-0 1997 Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70. Kainic Acid 13-24 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 83-104 8848100-7 1995 Since inducible heat-shock protein-70 keeps native proteins unfolded to prevent abnormal configuration following diverse insults, heat-shock protein-70 is proposed as a marker of transient impaired assembly of native proteins in sensitive neurons and axons following intraperitoneal kainate injection. Kainic Acid 283-290 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 130-151 7655348-3 1995 Kainic acid causes an increase in metallothionein-I and heme oxygenase-I mRNAs, as well as an increase in c-fos, heat shock protein-70, and interleukin-1 beta mRNAs. Kainic Acid 0-11 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 113-134 7757264-7 1995 In addition, MK-801 inhibited the kainic acid-induced expression of HSP-70 mRNA and protein in certain brain regions, notably the cortex, the pyramidal cell layer of CA1, and discrete thalamic nuclei. Kainic Acid 34-45 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 68-74 7757264-2 1995 Five hours after administration of kainic acid alone, dense expression of HSP-70 mRNA was found within the limbic system, mainly in the hippocampus, piriform and entorhinal cortices, amygdaloid complex, thalamic nuclei, subiculum and in other cortical areas in rats that had shown convulsive behaviour. Kainic Acid 35-46 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 74-80 7757264-10 1995 These results show that early regional expression of inducible HSP-70 mRNA allows the visualization of regions affected by kainic acid and maps regions inhibited by MK-801. Kainic Acid 123-134 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 63-69 8051566-11 1994 Kainic acid induced large amounts of hsp70 in both hippocampus and frontal cortex of sham-operated rats that was markedly attenuated (85-95%) by ADX. Kainic Acid 0-11 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 37-42 7533233-3 1994 Kainic acid treatment in rats, showing severe limbic convulsions, caused intense expression of hsp-70 mRNA and protein (HSP-70). Kainic Acid 0-11 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 95-101 7533233-3 1994 Kainic acid treatment in rats, showing severe limbic convulsions, caused intense expression of hsp-70 mRNA and protein (HSP-70). Kainic Acid 0-11 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 120-126 8281126-0 1993 Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia. Kainic Acid 113-124 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 61-86 8271311-5 1993 hsp70 mRNA was markedly induced in rat brain 8 hours following global ischemia and kainic acid-induced seizures. Kainic Acid 83-94 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 0-5 8271311-6 1993 Northern blots showed a approximately 2.9kb hsp70 mRNA band from control, kainic acid, and ischemic brains. Kainic Acid 74-85 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 44-49 2761775-2 1989 After kainic acid (KA) induced status epilepticus we observed HSP70 immunoreactivity in the hippocampal CA4 and CA1 sectors, the subiculum, the basolateral and the lateral nuclei of the amygdala, the mediodorsal nucleus of the thalamus, the caudal part of the striatum, the claustrum and in neurons of certain neocortical areas. Kainic Acid 6-17 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 62-67 3402596-0 1988 Stereotaxic injection of kainic acid into the striatum of rats induces synthesis of mRNA for heat shock protein 70. Kainic Acid 25-36 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 93-114