PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9344561-0	1997	The distribution of beta-amyloid precursor protein in rat cortex after systemic kainate-induced seizures.	Kainic Acid	80-87	amyloid beta precursor protein	Rattus norvegicus	20-50	
12672551-2	2003	In this report, non-toxic amounts of kainate were co-injected with Abeta into rat hippocampus.	Kainic Acid	37-44	amyloid beta precursor protein	Rattus norvegicus	67-72	
12672551-3	2003	Nissl-stained brain sections revealed that Abeta/kainate co-injection exerted synergistic neuronal degeneration in the hippocampus as well as that by Abeta/ibotenate co-injection.	Kainic Acid	49-56	amyloid beta precursor protein	Rattus norvegicus	150-155	
12672551-5	2003	On the other hand, 6-cyano-7-nitroquinoxaline-2, 3-dione, a kainate receptor antagonist, suppressed the neuronal loss induced by the Abeta/kainate co-injection, but not that by the Abeta/ibotenate co-injection.	Kainic Acid	60-67	amyloid beta precursor protein	Rattus norvegicus	133-138	
9344561-1	1997	In the current study we employed immunohistochemical techniques to identify neuronal and glial cells in specific brain areas that modulate beta-amyloid precursor protein (betaAPP) synthesis following kainate-induced seizures.	Kainic Acid	200-207	amyloid beta precursor protein	Rattus norvegicus	139-169	
8381908-4	1993	We have studied the expression of four beta APP isoforms in the rat brain after intracerebroventricular application of kainic acid.	Kainic Acid	119-130	amyloid beta precursor protein	Rattus norvegicus	39-47	
1640496-1	1992	Kainic acid lesions of rat striatum caused an elevation of amyloid precursor protein (APP) immunoreactivity in neurons and neurites, some of which were then phagocytosed by reactive microglia/macrophages.	Kainic Acid	0-11	amyloid beta precursor protein	Rattus norvegicus	59-84	
29665128-4	2019	Thus, we seek to establish what role Abeta plays in kainic acid-induced toxicity using in vivo and in vitro paradigms.	Kainic Acid	52-63	amyloid beta precursor protein	Rattus norvegicus	37-42	
29665128-5	2019	Our results show that systemic injection of kainic acid to adult rats triggers seizures, gliosis and loss of hippocampal neurons, along with increased levels/processing of amyloid precursor protein (APP), resulting in the enhanced production of Abeta-related peptides.	Kainic Acid	44-55	amyloid beta precursor protein	Rattus norvegicus	172-197	
29665128-5	2019	Our results show that systemic injection of kainic acid to adult rats triggers seizures, gliosis and loss of hippocampal neurons, along with increased levels/processing of amyloid precursor protein (APP), resulting in the enhanced production of Abeta-related peptides.	Kainic Acid	44-55	amyloid beta precursor protein	Rattus norvegicus	245-250	
29665128-6	2019	The changes in APP levels/processing were evident primarily in activated astrocytes, implying a role for astrocytic Abeta in kainic acid-induced toxicity.	Kainic Acid	125-136	amyloid beta precursor protein	Rattus norvegicus	116-121	
29665128-7	2019	Accordingly, we showed that treating rat primary cultured astrocytes with kainic acid can lead to increased Abeta production/secretion without any compromise in cell viability.	Kainic Acid	74-85	amyloid beta precursor protein	Rattus norvegicus	108-113	
29665128-8	2019	Additionally, we revealed that kainic acid reduces neuronal viability more in neuronal/astrocyte co-cultures than in pure neuronal culture, and this is attenuated by precluding Abeta production.	Kainic Acid	31-42	amyloid beta precursor protein	Rattus norvegicus	177-182	
29665128-9	2019	Collectively, these results indicate that increased production/secretion of Abeta-related peptides from activated astrocytes can contribute to neurotoxicity in kainic acid-treated rats.	Kainic Acid	160-171	amyloid beta precursor protein	Rattus norvegicus	76-81	
1306490-0	1992	Amyloid precursor protein mRNA encoding the Kunitz protease inhibitor domain is increased by kainic acid-induced seizures in rat hippocampus.	Kainic Acid	93-104	amyloid beta precursor protein	Rattus norvegicus	0-25