PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21876517-4 2011 RESULTS: Elevated PRL levels were found in about 45% of the patients and occurred more often in patients receiving risperidone or haloperidol, compared to patients receiving clozapine or olanzapine. Clozapine 174-183 prolactin Homo sapiens 18-21 23090266-7 2012 Prolactin levels were higher in the patients treated with olanzapine compared with in those treated with clozapine at study start, but there were no differences in the other parameters between the treatment groups at study start. Clozapine 105-114 prolactin Homo sapiens 0-9 21876517-9 2011 CONCLUSIONS: Our findings point to that hyperprolactinemia due to 1st and 2nd generation antipsychotics may decrease insulin sensitivity, whereas other mechanisms probably underlie insulin resistance induced by PRL-sparing antipsychotics such as clozapine and olanzapine. Clozapine 246-255 prolactin Homo sapiens 211-214 17110820-3 2006 The effect of reducing prolactin levels by switching patients" antipsychotic treatment to clozapine was ascertained by performing the measures before and after the switch to clozapine. Clozapine 90-99 prolactin Homo sapiens 23-32 19702492-2 2009 METHOD: Data on prolactin levels were available for haloperidol, pimozide, risperidone, olanzapine, clozapine, ziprasidone, and quetiapine. Clozapine 100-109 prolactin Homo sapiens 16-25 19702492-4 2009 RESULTS: All antipsychotics, except clozapine, ziprasidone, and quetiapine, increase the mean prolactin level from baseline values of 8.0 ng/mL to 25-28 ng/mL after 4 weeks of treatment (reference range 0-15 ng/mL). Clozapine 36-45 prolactin Homo sapiens 94-103 19551763-4 2009 RESULTS: For males, post-treatment PRL levels were significantly higher in the typical neuroleptic group compared with the melperone (p = 0.0001) and clozapine (p = 0.0001) groups, with no significant difference between clozapine and melperone. Clozapine 220-229 prolactin Homo sapiens 35-38 19551763-7 2009 However, the cross-sectional analysis of PRL data confirmed the results for melperone- and clozapine-treated females, and showed higher PRL levels in typical neuroleptic-treated females as compared with those who received melperone and clozapine. Clozapine 91-100 prolactin Homo sapiens 41-44 17110820-8 2006 This could be because prolactin does not have a major effect on glucose homeostasis or that the effects of prolactin reduction are countered by clozapine. Clozapine 144-153 prolactin Homo sapiens 107-116 19551763-0 2009 Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics. Clozapine 47-56 prolactin Homo sapiens 79-88 17110820-3 2006 The effect of reducing prolactin levels by switching patients" antipsychotic treatment to clozapine was ascertained by performing the measures before and after the switch to clozapine. Clozapine 174-183 prolactin Homo sapiens 23-32 17110820-5 2006 There was a large reduction in prolactin (593 mIU/L) after switching to clozapine, but this was not associated with changes in glucose-insulin measures. Clozapine 72-81 prolactin Homo sapiens 31-40 15286066-5 2004 RESULTS: Prolactin levels increased across medication groups reflecting increasingly tight D(2) receptor binding (clozapine, olanzapine, typical antipsychotics and risperidone). Clozapine 114-123 prolactin Homo sapiens 9-18 15960571-6 2005 In addition, there was a significant difference in median PRL level among the treatment groups (p < .0001), in that the PRL level was higher both in the patients treated with risperidone and in the patients treated with olanzapine, compared to those treated with clozapine. Clozapine 266-275 prolactin Homo sapiens 58-61 15960571-6 2005 In addition, there was a significant difference in median PRL level among the treatment groups (p < .0001), in that the PRL level was higher both in the patients treated with risperidone and in the patients treated with olanzapine, compared to those treated with clozapine. Clozapine 266-275 prolactin Homo sapiens 123-126 15960571-8 2005 CONCLUSION: Treatment with risperidone was frequently associated with hyperprolactinemia and related symptoms, whereas the occurrence of PRL elevation and related symptoms was modest in patients receiving olanzapine and nonexistent in those receiving clozapine. Clozapine 251-260 prolactin Homo sapiens 137-140 15365707-0 2004 Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment. Clozapine 105-114 prolactin Homo sapiens 76-85 15365707-1 2004 In vitro, animal studies and acute short-term clinical studies suggest clozapine releases prolactin but the effect is much smaller than that of typical antipsychotics. Clozapine 71-80 prolactin Homo sapiens 90-99 15671135-4 2005 We present a patient with treatment resistant schizophrenia and a prolactin-secreting microadenoma of the pituitary who was intolerant of clozapine therapy. Clozapine 138-147 prolactin Homo sapiens 66-75 15365707-5 2004 The within-subject correlation of prolactin levels was 0.32 with clozapine levels and 0.75 with haloperidol levels. Clozapine 65-74 prolactin Homo sapiens 34-43 15365707-6 2004 An increment of 100 ng/ml in clozapine level yielded an average increment of 0.45 ng/ml of prolactin levels in females and of 0.15 ng/ml in males. Clozapine 29-38 prolactin Homo sapiens 91-100 15365707-8 2004 At least one fourth of patients demonstrated a significant and strong (r > 0.6) correlation between clozapine and prolactin levels. Clozapine 103-112 prolactin Homo sapiens 117-126 15365707-9 2004 This study suggests that clozapine has effects on prolactin levels but effects are small and may be more evident in some individuals, particularly females. Clozapine 25-34 prolactin Homo sapiens 50-59 15286066-7 2004 In patients treated with clozapine (the loosest D(2) receptor binding agent), patients with the DRD2(*)A1allele had prolactin levels twice those of patients without this allele. Clozapine 25-34 prolactin Homo sapiens 116-125 12188977-0 2002 Correlation of antipsychotic and prolactin concentrations in children and adolescents acutely treated with haloperidol, clozapine, or olanzapine. Clozapine 120-129 prolactin Homo sapiens 33-42 14744169-0 2004 Prolactin levels in schizophrenia and schizoaffective disorder patients treated with clozapine, olanzapine, risperidone, or haloperidol. Clozapine 85-94 prolactin Homo sapiens 0-9 14744169-10 2004 Clozapine and olanzapine were associated with decreases of prolactin, whereas haloperidol led to a minor, nonsignificant increase. Clozapine 0-9 prolactin Homo sapiens 59-68 12387684-12 2002 With the application of clozapine and other atypical antipsychotics, it was found that medications can successfully treat psychosis without increasing hPrl. Clozapine 24-33 prolactin Homo sapiens 151-155 12387684-13 2002 In fact, early single-dose trails found clozapine to reduce hPrl by 16%. Clozapine 40-49 prolactin Homo sapiens 60-64 12585566-5 2002 At the other end of the spectrum, clozapine and quetiapine produce minimal sustained increases in prolactin that are no different from placebo. Clozapine 34-43 prolactin Homo sapiens 98-107 11561931-3 2001 The goal of this study was to determine whether the addition of risperidone to clozapine results in an elevation of serum prolactin levels in patients with chronic schizophrenia or schizoaffective disorder. Clozapine 79-88 prolactin Homo sapiens 122-131 12084414-0 2002 Prolactin responses to acute clomipramine and haloperidol of male schizophrenic patients in a drug-free state and after treatment with clozapine or with olanzapine. Clozapine 135-144 prolactin Homo sapiens 0-9 11561931-8 2001 The mean +/- SD serum prolactin level was 8.42+/-4.17 ng/mL for clozapine monotherapy patients and 35.76+/-17.43 ng/mL for combination therapy patients. Clozapine 64-73 prolactin Homo sapiens 22-31 11561931-11 2001 CONCLUSION: The combination of risperidone and clozapine appears to result in a moderate elevation of serum prolactin levels. Clozapine 47-56 prolactin Homo sapiens 108-117 9619161-5 1998 RESULTS: The prolactin response was significantly blunted in these 20 patients treated with clozapine. Clozapine 92-101 prolactin Homo sapiens 13-22 11155212-5 2000 The mean prolactin concentration (all ng/mL +/- standard deviation) was also significantly higher in patients taking risperidone (women, 125.0 +/- 56.6; men, 37.3 +/- 23.9) than clozapine (women, 22.0 +/- 25.9; men, 13.3 +/- 22.4) (female patients, P = 0.0004; male patients, P<0.0001) or typical antipsychotic agents (women, 69.0 +/- 59.8; men, 13. Clozapine 178-187 prolactin Homo sapiens 9-18 9989565-2 1999 The new antipsychotics clozapine, risperidone, and olanzapine obtain antipsychotic response with few extrapyramidal side effects and little prolactin elevation. Clozapine 23-32 prolactin Homo sapiens 140-149 9829289-2 1998 The study aimed to search for the effect of clozapine on the levels of the main metabolites of dopamine homovanillic acid (HVA), serotonin 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine 3-methoxy-4-hydroxyphenylglycol (MHPG) in urine as well as on plasma levels of HVA, 5-HIAA, prolactin (PRL) and cortisol. Clozapine 44-53 prolactin Homo sapiens 297-300 11156818-0 2001 Increased dopamine d(2) receptor occupancy and elevated prolactin level associated with addition of haloperidol to clozapine. Clozapine 115-124 prolactin Homo sapiens 56-65 11156818-5 2001 CONCLUSIONS: Adding a modest dose of haloperidol to clozapine results in the high D(2) receptor occupancy and sustained prolactin elevation usually associated with typical antipsychotics. Clozapine 52-61 prolactin Homo sapiens 120-129 11156818-6 2001 These findings suggest that the lack of prolactin elevation associated with clozapine derives mainly from low D(2) receptor occupancy and not from the medication"s effects on other receptors. Clozapine 76-85 prolactin Homo sapiens 40-49 26976681-2 2000 The atypical antipsychotic clozapine barely increases prolactin levels. Clozapine 27-36 prolactin Homo sapiens 54-63 10630453-5 1999 Prolactin was increased above the upper limit of normal for 100% of 10 patients on haloperidol, 70% of 10 patients on olanzapine, and 0% of 15 patients on clozapine (chi2 analyses: H > C, p = 0.004; O > C, p = 0.001). Clozapine 155-164 prolactin Homo sapiens 0-9 9619161-7 1998 CONCLUSIONS: Blunted 5-HT-mediated prolactin responses in schizophrenic patients receiving clozapine monotherapy for up to 20 months were correlated with reductions in positive symptoms. Clozapine 91-100 prolactin Homo sapiens 35-44 8453823-11 1993 Clozapine transiently increases serum prolactin levels with minimal changes in homovanillic acid plasma levels. Clozapine 0-9 prolactin Homo sapiens 38-47 9192542-3 1997 We describe a case of attenuated serum prolactin levels after conversion to clozapine therapy in an adolescent. Clozapine 76-85 prolactin Homo sapiens 39-48 9192542-7 1997 Clozapine 150 mg twice daily improved her psychiatric status and corrected her serum prolactin concentrations after 2 weeks; bromocriptine was able to be discontinued. Clozapine 0-9 prolactin Homo sapiens 85-94 8740053-3 1996 This study investigated the relationship between receptor occupancy and plasma prolactin levels in 12 male patients treated with haloperidol, benperidol or clozapine. Clozapine 156-165 prolactin Homo sapiens 79-88 2573106-2 1989 Compared to classical neuroleptics, clozapine causes only a short-lasting elevation of plasma prolactin levels, elevates both striatal homovanillic acid and dopamine content, is devoid of marked apomorphine-inhibitory or cataleptogenic activity and fails to induce supersensitivity of striatal dopaminergic systems after chronic administration. Clozapine 36-45 prolactin Homo sapiens 94-103 34581701-0 2021 Metabolic Effects of Clozapine Administration Based on Sex Differences and the Relationships Between Dosage and Prolactin Levels: An Observational Study. Clozapine 21-30 prolactin Homo sapiens 112-121 34581701-3 2021 This study aimed to investigate the effects of clozapine treatment on metabolic and neuroendocrine parameters, and the relationships between prescribed clozapine dosage and prolactin levels that may be associated with plasma clozapine concentrations, in 24 female and 24 male Japanese schizophrenia inpatients switched to clozapine. Clozapine 152-161 prolactin Homo sapiens 173-182 34581701-3 2021 This study aimed to investigate the effects of clozapine treatment on metabolic and neuroendocrine parameters, and the relationships between prescribed clozapine dosage and prolactin levels that may be associated with plasma clozapine concentrations, in 24 female and 24 male Japanese schizophrenia inpatients switched to clozapine. Clozapine 225-234 prolactin Homo sapiens 173-182 2682729-3 1989 These PRL results are consistent with the observation that clozapine may increase DA release. Clozapine 59-68 prolactin Homo sapiens 6-9 2682729-6 1989 We hypothesize that antagonism of D-2 and 5-HT2 receptors and enhancement of DA and 5-HT release are critical elements in the action of clozapine to minimize both positive and negative symptoms without producing significant extrapyramidal symptoms or plasma PRL increases. Clozapine 136-145 prolactin Homo sapiens 258-261 7831446-4 1993 This study investigated the effects of cimetidine on plasma PRL levels in unmedicated schizophrenic patients versus normal controls and the effect of chronic treatment with clozapine on the cimetidine-induced PRL response. Clozapine 173-182 prolactin Homo sapiens 209-212 7831446-7 1993 Chronic treatment with clozapine completely suppressed the plasma PRL response following cimetidine. Clozapine 23-32 prolactin Homo sapiens 66-69 1586397-4 1992 The failure of clozapine to elevate serum prolactin concentrations may be related to the stimulatory effect of clozapine on tuberoinfundibular dopamine neurons and/or the failure of clozapine to achieve effective blockade of pituitary dopamine D2 receptors. Clozapine 15-24 prolactin Homo sapiens 42-51 2325501-12 1990 These observations suggest that the transient PRL-releasing effects which have been observed in both animal and human studies after clozapine administration are mediated via supra-pituitary actions of the drug. Clozapine 132-141 prolactin Homo sapiens 46-49 507205-1 1979 The authors determined serum prolactin levels in 13 patients receiving clozapine, an antipsychotic drug that does not produce extrapyramidal side effects. Clozapine 71-80 prolactin Homo sapiens 29-38 431802-2 1979 Clozapine caused a slight (17%) but significant elevation in basal serum prolactin levels. Clozapine 0-9 prolactin Homo sapiens 73-82 507205-0 1979 Effect of clozapine on human serum prolactin levels. Clozapine 10-19 prolactin Homo sapiens 35-44 507205-3 1979 Serum prolactin levels were moderately increased between 90 minutes and 4 hours after administration of very high doses of oral clozapine in 4 patients but were smaller than those produced by chlorpromazine in other subjects. Clozapine 128-137 prolactin Homo sapiens 6-15 1160505-0 1975 Clozapine increases rat serum prolactin levels. Clozapine 0-9 prolactin Homo sapiens 30-39 26816428-0 2015 Comparative study of sexual dysfunction and serum prolactin level associated with olanzapine, risperidone, and clozapine in patients with remitted schizophrenia. Clozapine 111-120 prolactin Homo sapiens 50-59 26816428-13 2015 Prolactin level elevation was statistically significant in risperidone group followed by clozapine and olanzapine groups, respectively. Clozapine 89-98 prolactin Homo sapiens 0-9