PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24410629-2 2014 The major event of the mechanism of their mutagenicity is N-hydroxylation by P450 enzymes, primarily P450 1A2 (CYP1A2), which leads to the formation of nitrenium ions that covalently modify nucleobases of DNA. nitrenium 152-161 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 111-117