PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35234137-3 2022 The discovery of new scaffold molecules, a pyrano-1,3-oxazine derivative (NSC 328111; NS5) and phenanthridinone-based derivatives (L10 and its core moiety L10a), as inhibitors of BRD2 bromodomains BD1 and BD2, respectively, has recently been reported. phenanthridone 95-111 immunoglobulin kappa variable 3-7 (non-functional) Homo sapiens 155-159 28696179-3 2018 We have recently reported the discovery of a new scaffold of the phenanthridinone-based inhibitor (L10) of the second bromodomain of BRD2 (BRD2-BD2). phenanthridone 65-81 immunoglobulin kappa variable 3-7 (non-functional) Homo sapiens 99-102 28696179-7 2018 Next, to confirm whether phenanthridionone scaffold is a new inhibitor family of BRD2-BD2, we have determined the crystal structure of BD2 in complex with 6(5H)-Phenanthridinone (a core moiety of L10), refined to 1.28 A resolution. phenanthridone 155-177 immunoglobulin kappa variable 3-7 (non-functional) Homo sapiens 196-199