PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8530505-3 1995 An aspartic acid (residue 289 or 478) that is invariant in repeats a and b of all known cGMP-binding PDEs was changed to alanine by site-directed mutagenesis of cGB-PDE, and wild type (WT) and mutant cGB-PDEs were expressed in COS-7 cells. Alanine 121-128 phosphodiesterase 5A Bos taurus 161-168