PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10648402-2 2000 The vWf-binding site on GP Ib-IX-V is within the N-terminal 282 residues of GP Ibalpha, which consist of an N-terminal flanking sequence (His-1-Ile-35), 7 leucine-rich repeats (Leu-36-Ala-200), a C-terminal flank (Phe-201-Gly-268), and a sulfated tyrosine sequence (Asp-269-Glu-282). Alanine 184-187 von Willebrand factor Homo sapiens 4-7 12969981-0 2004 Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development. Alanine 12-19 von Willebrand factor Homo sapiens 107-110 12069583-6 2002 A panel of recombinant VWF, in which alanine-scanning mutagenesis was introduced to the charged amino acid residues in the A1 domain, showed that the bitiscetin-binding activity was reduced in mutations at Arg632, Lys660, Glu666, and Lys673 of the A1 domain. Alanine 37-44 von Willebrand factor Homo sapiens 23-26 15606553-8 2005 Any alanine-substitution for T705 revealed a substantial loss in aggregatory effects - possibly as a result of structural desintegration of the VWF-A1-binding site for glycoprotein (GP) Ib. Alanine 4-11 von Willebrand factor Homo sapiens 144-147 14757772-0 2004 Identification of the amino acid residues of the platelet glycoprotein Ib (GPIb) essential for the von Willebrand factor binding by clustered charged-to-alanine scanning mutagenesis. Alanine 153-160 von Willebrand factor Homo sapiens 99-120 11876992-0 2000 [Construction and transient expression of an Ala 737-->Glu mutant of vWF]. Alanine 45-48 von Willebrand factor Homo sapiens 72-75 9865467-0 1998 Ser752 mutation to Pro or Ala in the beta3 integrin subunit differentially affects the kinetics of cell spreading to von Willebrand factor and fibrinogen. Alanine 26-29 von Willebrand factor Homo sapiens 117-138 9657753-6 1998 Insertion of an alanine residue at the N-terminus of the mature vWF subunit destroyed binding to factor VIII, indicating that the native mature N-terminus is required for factor VIII binding. Alanine 16-23 von Willebrand factor Homo sapiens 64-67 7539426-1 1995 Charged-to-alanine scanning mutagenesis of the A1 domain of human von Willebrand factor. Alanine 11-18 von Willebrand factor Homo sapiens 66-87 7539426-3 1995 The VWF-GPIb interaction was investigated by clustered charged-to-alanine scanning mutagenesis of VWF domain A1 between His-473 and Gly-716. Alanine 66-73 von Willebrand factor Homo sapiens 4-7 7539426-3 1995 The VWF-GPIb interaction was investigated by clustered charged-to-alanine scanning mutagenesis of VWF domain A1 between His-473 and Gly-716. Alanine 66-73 von Willebrand factor Homo sapiens 98-101 8120035-8 1994 Furthermore, recombinant vWF with Gly or Ala at all three positions induces platelet aggregation in the presence of ristocetin and binds to platelet glycoprotein Ib, factor VIII, and collagen in a manner similar to wild-type recombinant vWF. Alanine 41-44 von Willebrand factor Homo sapiens 25-28 24283831-5 2014 METHODS AND RESULTS: Both full-length VWF and VWF fragments with cysteine to alanine mutations of the nine cysteines and two predicted binding partners (Cys2431 and Cys2468) failed to secrete. Alanine 77-84 von Willebrand factor Homo sapiens 46-49 1737795-2 1992 A glycine to alanine substitution yielded RADS-vWF, while an aspartate to glutamate substitution resulted in RGES-vWF. Alanine 13-20 von Willebrand factor Homo sapiens 47-50 31675465-6 2020 The identified residues were replaced into alanine residues to identify their role in FIXa and VWF interaction. Alanine 43-50 von Willebrand factor Homo sapiens 95-98 31675465-10 2020 Substitution into alanine of the also surface-exposed V2125, which is spatially next to F2127, affected only VWF binding. Alanine 18-25 von Willebrand factor Homo sapiens 109-112 22754302-4 2012 In the present study, the data indicate that the S609A mutation replacing Ser(609) of GPIbalpha with alanine (S609A) significantly prevented the association of 14-3-3zeta with GPIbalpha before and after the VWF binding to GPIbalpha. Alanine 101-108 von Willebrand factor Homo sapiens 207-210 19875727-7 2009 Furthermore, a GPIb-IX mutant replacing Ser559 of GPIbalpha with alanine showed an enhanced association with the membrane skeleton, reduced ristocetin-induced VWF binding, and diminished ability to mediate cell adhesion to VWF under flow conditions. Alanine 65-72 von Willebrand factor Homo sapiens 159-162 19875727-7 2009 Furthermore, a GPIb-IX mutant replacing Ser559 of GPIbalpha with alanine showed an enhanced association with the membrane skeleton, reduced ristocetin-induced VWF binding, and diminished ability to mediate cell adhesion to VWF under flow conditions. Alanine 65-72 von Willebrand factor Homo sapiens 223-226 18369690-0 2008 Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis. Alanine 111-118 von Willebrand factor Homo sapiens 54-75 18923835-3 2009 We made an attempt to correlate the 789Ala/Ala genotype of the VWF with VWF:Ag level in different types of unrelated von Willebrand disease (VWD) patients and healthy controls. Alanine 39-42 von Willebrand factor Homo sapiens 63-66 18923835-3 2009 We made an attempt to correlate the 789Ala/Ala genotype of the VWF with VWF:Ag level in different types of unrelated von Willebrand disease (VWD) patients and healthy controls. Alanine 39-42 von Willebrand factor Homo sapiens 72-75 18923835-9 2009 These results demonstrate that mutant homozygous 789Ala/Ala genotype of this polymorphism probably have their functional implications for low plasma VWF:Ag level in quantitative type of VWD. Alanine 52-55 von Willebrand factor Homo sapiens 149-152