PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32054416-5 2020 Alanine scanning of CTLA-4 using mammalian cell expression cassette identified the unique epitopes of this novel antibody. Alanine 0-7 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 20-26 8981012-7 1996 This study also confirms that the allele HLA DQA1* 0501 confers susceptibility to Graves" disease, furthermore, that the CTLA4-alanine 17 allele is an additional predisposing factor. Alanine 127-134 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 121-126 8989248-0 1997 CTLA4 alanine-17 confers genetic susceptibility to Graves" disease and to type 1 diabetes mellitus. Alanine 6-13 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 0-5 8989248-8 1997 In conclusion, an alanine at codon 17 of CTLA4 is associated with genetic susceptibility to Graves" disease as well as to IDDM. Alanine 18-25 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 41-46 31340988-5 2019 AtoG polymorphism at position +49 of CTLA4 gene is the only polymorphism which changes amino acid sequence from alanine to threonine in the leader sequence, which may affect the function of CTLA-4. Alanine 112-119 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 37-42 31340988-5 2019 AtoG polymorphism at position +49 of CTLA4 gene is the only polymorphism which changes amino acid sequence from alanine to threonine in the leader sequence, which may affect the function of CTLA-4. Alanine 112-119 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 190-196 16405845-12 2005 CONCLUSION: CTLA-4 gene exon 1 A49-->G substitution is associated with an increased IDC genetic susceptibility, which implicates that the CTLA-4 gene may have a significant role in IDC, possibly via a Thr-->Ala change in CTLA-4 signal peptide, with a result of functional change of sCTLA-4. Alanine 213-216 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 12-18 18757416-6 2008 We found that the 49G>A polymorphism in the CTLA-4 leading sequence causing (17)Ala to (17)Thr amino acid substitution is associated with increased susceptibility to multiple cancers, including lung, breast, esophagus, and gastric cardia cancers. Alanine 80-83 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 44-50 16405845-12 2005 CONCLUSION: CTLA-4 gene exon 1 A49-->G substitution is associated with an increased IDC genetic susceptibility, which implicates that the CTLA-4 gene may have a significant role in IDC, possibly via a Thr-->Ala change in CTLA-4 signal peptide, with a result of functional change of sCTLA-4. Alanine 213-216 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 141-147 16405845-12 2005 CONCLUSION: CTLA-4 gene exon 1 A49-->G substitution is associated with an increased IDC genetic susceptibility, which implicates that the CTLA-4 gene may have a significant role in IDC, possibly via a Thr-->Ala change in CTLA-4 signal peptide, with a result of functional change of sCTLA-4. Alanine 213-216 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 141-147 11788096-3 2001 A polymorphism at position 49 in the CTLA-4 gene, causing a substitution of Thr --> Ala, has been associated with various autoimmune diseases, including diabetes. Alanine 87-90 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 37-43 15218356-1 2004 The exon 1 polymorphism (49A/G) of ctla-4 gene corresponds to an amino acid exchange (threonine to alanine) in the leader peptide of the expressed protein. Alanine 99-106 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 35-41 12047362-2 2002 Several studies have demonstrated an association of cytotoxic T lymphocyte-associated molecule 4 (CTLA-4) (IDDM 12) alanine 17 with type 1 diabetes, but we wished to study the parental effect of CTLA-4 49 A/G dimorphism in diabetic families. Alanine 116-123 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 52-96 12047362-2 2002 Several studies have demonstrated an association of cytotoxic T lymphocyte-associated molecule 4 (CTLA-4) (IDDM 12) alanine 17 with type 1 diabetes, but we wished to study the parental effect of CTLA-4 49 A/G dimorphism in diabetic families. Alanine 116-123 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 98-104 12047362-2 2002 Several studies have demonstrated an association of cytotoxic T lymphocyte-associated molecule 4 (CTLA-4) (IDDM 12) alanine 17 with type 1 diabetes, but we wished to study the parental effect of CTLA-4 49 A/G dimorphism in diabetic families. Alanine 116-123 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 107-114 11880164-2 2002 The CTLA-4 polymorphisms genotyped were a 3" untranslated (AT)(n) microsatellite and an alanine/threonine RFLP of exon 1. Alanine 88-95 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 4-10 11900275-5 2002 Moreover, we assessed the CTLA-4 49 (Thr/Ala) polymorphism in diabetic patients and first-degree relatives as compared to control subjects. Alanine 41-44 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 26-32 11900275-11 2002 CONCLUSION: The CTLA-4 49 Ala allele confers an increased risk of type 1 diabetes, independent of age and HLA-DQ genetic markers. Alanine 26-29 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 16-22 9459504-6 1998 In contrast, analyses of the CTLA4 exon 1 polymorphism with respect to HLA-DRB1*04 revealed significantly more patients with Ala in the homozygous (19% versus 15% controls) or heterozygous state (54% versus 39% controls) and less homozygous for Thr (27% versus 46% controls), with a particular increase of Ala/Ala genotypes among rheumatoid arthritis patients carrying the HLA-DRB1*0401 subtype. Alanine 125-128 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 29-34 10724097-5 1999 CTLA4 exon 1 position 49 (A/G: codon 17: Thr/Ala) polymorphism was defined, employing PCR-RFLP. Alanine 45-48 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 0-5 11158025-1 2001 Several studies have demonstrated an association of CTLA4 (IDDM12) alanine-17 with type 1 diabetes, but CTLA4 variants have not yet been investigated in type 2 diabetes. Alanine 67-74 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 52-57 11158025-1 2001 Several studies have demonstrated an association of CTLA4 (IDDM12) alanine-17 with type 1 diabetes, but CTLA4 variants have not yet been investigated in type 2 diabetes. Alanine 67-74 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 59-65 11288988-4 2001 We evaluated the allele distribution of the following loci: CTLA-4 exon 1 A49G dimorphism, which resulted in an amino acidic exchange (Thr/Ala) in the leader peptide, CTLA-4 3" microsatellite, HLA DRB1 and DQB1 in 126 patients with HT and in 301 control subjects from an Italian population (Lazio region). Alanine 139-142 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 60-66 10782900-5 2000 METHODS: The CTLA-4 exon 1 polymorphism (A/G encoding for threonine or alanine, respectively) was genotyped via polymerase chain reaction in 200 Caucasoid PBC patients and 200 non-related geographically matched Caucasoid controls. Alanine 71-78 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 13-19 9459504-6 1998 In contrast, analyses of the CTLA4 exon 1 polymorphism with respect to HLA-DRB1*04 revealed significantly more patients with Ala in the homozygous (19% versus 15% controls) or heterozygous state (54% versus 39% controls) and less homozygous for Thr (27% versus 46% controls), with a particular increase of Ala/Ala genotypes among rheumatoid arthritis patients carrying the HLA-DRB1*0401 subtype. Alanine 306-309 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 29-34 9459504-6 1998 In contrast, analyses of the CTLA4 exon 1 polymorphism with respect to HLA-DRB1*04 revealed significantly more patients with Ala in the homozygous (19% versus 15% controls) or heterozygous state (54% versus 39% controls) and less homozygous for Thr (27% versus 46% controls), with a particular increase of Ala/Ala genotypes among rheumatoid arthritis patients carrying the HLA-DRB1*0401 subtype. Alanine 306-309 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 29-34 9398726-2 1997 Because the cytotoxic T lymphocyte antigen 4 (CTLA4) alanine-17 encoded by the CTLA4 gene on chromosome 2q33 confers susceptibility to Graves" disease, as well as to type 1 (insulin-dependent) diabetes mellitus, we investigated this dimorphism in the other endocrine autoimmune disorders: Hashimoto"s thyroiditis and Addison"s disease. Alanine 53-60 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 12-44 9398726-2 1997 Because the cytotoxic T lymphocyte antigen 4 (CTLA4) alanine-17 encoded by the CTLA4 gene on chromosome 2q33 confers susceptibility to Graves" disease, as well as to type 1 (insulin-dependent) diabetes mellitus, we investigated this dimorphism in the other endocrine autoimmune disorders: Hashimoto"s thyroiditis and Addison"s disease. Alanine 53-60 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 46-51 9398726-2 1997 Because the cytotoxic T lymphocyte antigen 4 (CTLA4) alanine-17 encoded by the CTLA4 gene on chromosome 2q33 confers susceptibility to Graves" disease, as well as to type 1 (insulin-dependent) diabetes mellitus, we investigated this dimorphism in the other endocrine autoimmune disorders: Hashimoto"s thyroiditis and Addison"s disease. Alanine 53-60 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 79-84 9398726-9 1997 In conclusion, an alanine at codon 17 of CTLA4 confers genetic susceptibility to Hashimoto"s thyroiditis, whereas this applies only to the subgroup of DQA1*0501+ patients with Addison"s disease. Alanine 18-25 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 41-46