PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21664945-7 2012 High affinity equilibrium androgen binding was retained by alanine substitution mutations at Tyr-739 in AR LBD helix 5 or Lys-905 in helix 12 structurally adjacent to AF2, whereas transcriptional activity decreased and the androgen dissociation increased. Alanine 59-66 androgen receptor Homo sapiens 104-106 18289734-4 2009 An exchange of two N-terminal serine phosphorylation residues to alanine in the wild type androgen receptor (ARQ22dm) resulted in cytoplasmic accumulation and increased early hormone-dependent aggregation of the receptor. Alanine 65-72 androgen receptor Homo sapiens 90-107 16456618-2 2006 Here, we describe a new AR variant found in a hormone-refractory metastatic PCa, in which threonine 575 in the DNA binding domain, and threonine 877 in the ligand-binding domain, were both replaced by an alanine. Alanine 204-211 androgen receptor Homo sapiens 24-26 17470458-5 2007 Co-expression of constitutively active Akt and the AR has similar consequences, which are blocked by alanine substitutions at residues 215 and 792. Alanine 101-108 androgen receptor Homo sapiens 51-53 17470458-8 2007 IGF-1 rescue of AR toxicity is diminished by alanine substitutions at the Akt consensus sites. Alanine 45-52 androgen receptor Homo sapiens 16-18 12482965-3 2003 Transcriptional analysis demonstrated that activation of the androgen receptor caused an inhibition of both wild-type FKHR and a mutant in which all three known AKT sites were mutated to alanines, showing that the repression is AKT independent. Alanine 187-195 androgen receptor Homo sapiens 61-78 15239671-7 2004 The activities of the Ser-Ala substitution mutant S650A (Ser-650-->Ala) was found to be identical with wild-type AR activation in four different cell lines and three different functional analyses, e.g. transactivation, N- and C-terminal-domain interaction and co-activation by transcriptional intermediary factor 2. Alanine 26-29 androgen receptor Homo sapiens 116-118 12644579-0 2003 Mutation of the androgen receptor at amino acid 708 (Gly-->Ala) abolishes partial agonist activity of steroidal antiandrogens. Alanine 62-65 androgen receptor Homo sapiens 16-33 12466388-5 2002 The gradual impairment of binding and trans-activation efficiencies in AR mutants ranging from alanine to valine and subsequently glutamic acid were highlighted by in vitro experiments. Alanine 95-102 androgen receptor Homo sapiens 71-73 8560673-8 1996 Studies with the LNCaP cell line are particularly interesting, as these cells contain a mutated androgen receptor (codon 868, Thr-->Ala), which behaves idiosyncratically with other antiandrogens (cyproterone acetate and flutamide): both these antiandrogens act as agonists in this cell line and stimulate proliferation. Alanine 135-138 androgen receptor Homo sapiens 96-113 12006704-6 2002 RESULTS: A point mutation at codon 870 of the AR, changing alanine to valine, was detected. Alanine 59-66 androgen receptor Homo sapiens 46-48 11719283-7 2001 The 92 kDa AR did not result from alternative initiation since it was observed when the second methionine was changed to alanine. Alanine 121-128 androgen receptor Homo sapiens 11-13 9421404-1 1998 In the androgen receptor of a patient with androgen insensitivity, the alanine residue at position 564 in the first zinc cluster of the DNA-binding domain was substituted by aspartic acid. Alanine 71-78 androgen receptor Homo sapiens 7-24 8274427-4 1993 An amino acid substitution alanine-596-->threonine in the D-box of the androgen receptor was detected in 3 and 2 brothers, respectively. Alanine 27-34 androgen receptor Homo sapiens 74-91 7649358-1 1995 A single exchange of an alanine to a threonine at amino acid position 596 in the androgen receptor has been identified as an inheritable trait in patients with Reifenstein syndrome. Alanine 24-31 androgen receptor Homo sapiens 81-98 8187068-2 1994 Direct sequencing of the polymerase chain reaction-derived DNAs of 6 of 24 specimens revealed a codon 877 mutation (ACT-->GCT, Thr-->Ala) in the hormone-binding domain of the AR gene. Alanine 139-142 androgen receptor Homo sapiens 181-183 8246999-0 1993 A mutant androgen receptor from patients with Reifenstein syndrome: identification of the function of a conserved alanine residue in the D box of steroid receptors. Alanine 114-121 androgen receptor Homo sapiens 9-26 8246999-7 1993 Exchanging alanine 596 in the wild-type androgen receptor with serine or valine produced mutants with properties indistinguishable from those of the naturally occurring threonine 596 mutant receptor. Alanine 11-18 androgen receptor Homo sapiens 40-57 8246999-8 1993 These results indicate that an alanine residue at position 596 contributes important structural and functional activities to the androgen receptor. Alanine 31-38 androgen receptor Homo sapiens 129-146 8246999-9 1993 In the androgen receptor from the patients with Reifenstein syndrome, in which this alanine is converted to a threonine, wild-type receptor properties can be restored by exchanging an additional threonine at position 602 to an alanine. Alanine 84-91 androgen receptor Homo sapiens 7-24 8246999-10 1993 An alanine residue at position 596 or 602 in the DNA binding domain of the androgen receptor is therefore important for the full function of this receptor. Alanine 3-10 androgen receptor Homo sapiens 75-92 8246999-11 1993 In all steroid receptors that bind the core sequence AGAACANNNTGTTCT, an alanine residue is also present at a position equivalent to alanine 596 in the androgen receptor. Alanine 73-80 androgen receptor Homo sapiens 152-169 8246999-11 1993 In all steroid receptors that bind the core sequence AGAACANNNTGTTCT, an alanine residue is also present at a position equivalent to alanine 596 in the androgen receptor. Alanine 133-140 androgen receptor Homo sapiens 152-169 1958538-8 1991 Sequence analysis of the androgen receptor in human LNCaP-cells (lymph node carcinoma of the prostate) revealed a point mutation (A----G) in codon 868 in exon 8 resulting in the substitution of threonine by alanine. Alanine 207-214 androgen receptor Homo sapiens 25-42 8216289-1 1993 The human androgen receptor gene in the androgen sensitive prostate tumor cell line (LNCaP) contains a point mutation in codon 868 resulting in the substitution of threonine by alanine. Alanine 177-184 androgen receptor Homo sapiens 10-27 8498155-7 1993 The results demonstrate that the substitution of nucleotide (guanine-->cytosine) in exon G of the androgen receptor causes the replacement of an amino acid in position 820 (glycine-->alanine) which occurs in the hormone-binding domain of the androgen receptor. Alanine 189-196 androgen receptor Homo sapiens 101-118 8498155-7 1993 The results demonstrate that the substitution of nucleotide (guanine-->cytosine) in exon G of the androgen receptor causes the replacement of an amino acid in position 820 (glycine-->alanine) which occurs in the hormone-binding domain of the androgen receptor. Alanine 189-196 androgen receptor Homo sapiens 248-265 1426313-6 1992 CONCLUSION: The subsequent alanine to threonine amino acid conversion may have resulted in a configurational change of the androgen receptor protein leading to complete androgen insensitivity. Alanine 27-34 androgen receptor Homo sapiens 123-140 1598912-10 1992 The mutation is a guanine-to-adenine transition at nucleotide 2314, which changes the alanine codon (GCC) immediately after the first cysteine of the second zinc finger motif of the AR into a threonine codon (ACC). Alanine 86-93 androgen receptor Homo sapiens 182-184 1540595-1 1992 Previous studies from this laboratory have described that LNCaP prostate tumor cells contain an androgen receptor (AR) with a point mutation in the steroid-binding domain (codon 868, Thr to Ala). Alanine 190-193 androgen receptor Homo sapiens 96-113 1540595-1 1992 Previous studies from this laboratory have described that LNCaP prostate tumor cells contain an androgen receptor (AR) with a point mutation in the steroid-binding domain (codon 868, Thr to Ala). Alanine 190-193 androgen receptor Homo sapiens 115-117 1668832-2 1991 The gene for the androgen receptor (AR) in the androgen-sensitive human prostate cancer cell line LNCaP has a single-base mutation that produces a threonine to alanine change in the androgen-binding domain. Alanine 160-167 androgen receptor Homo sapiens 17-34 1668832-2 1991 The gene for the androgen receptor (AR) in the androgen-sensitive human prostate cancer cell line LNCaP has a single-base mutation that produces a threonine to alanine change in the androgen-binding domain. Alanine 160-167 androgen receptor Homo sapiens 36-38 2285596-8 1990 Sequence analysis showed that the androgen receptor gene from LNCaP cells contains a point mutation in the region encoding the steroid-binding domain, which confers an ACT codon encoding a threonine residue to GCT, encoding alanine. Alanine 224-231 androgen receptor Homo sapiens 34-51