PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11353811-4 2001 Studying cardiac energy metabolism in Langendorff heart perfusion system by (31)P NMR, we found that PARP inhibitors (3-aminobenzamide, nicotinamide, BGP-15, and 4-hydroxyquinazoline) improved the recovery of high-energy phosphates (ATP, creatine phosphate) and accelerated the reutilization of inorganic phosphate formed during the ischemic period, showing that PARP inhibitors facilitate the faster and more complete recovery of the energy production. Phosphocreatine 238-256 poly(ADP-ribose) polymerase 1 Homo sapiens 101-105 16337154-7 2006 Blocking PI3-kinase by wortmannin or LY294002 reduced the PARP inhibitor-elicited robust Akt and GSK-3beta phosphorylation upon ischemia-reperfusion, and significantly diminished the recovery of ATP and creatine phosphate showing the importance of Akt activation in the recovery of energy metabolism. Phosphocreatine 203-221 poly(ADP-ribose) polymerase 1 Homo sapiens 58-62