PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24225957-4	2014	We have determined the first crystal structure of a disaccharide analog of Gb3 bound to the B5 pentamer of Stx2a holotoxin.	stichoposide	113-122	syntaxin 2	Homo sapiens	107-112	
28398250-3	2017	However, it is not clear why Shiga toxin 1 (Stx1) or Shiga toxin 2 (Stx2) holotoxin is not active in a cell-free system.	stichoposide	74-83	syntaxin 2	Homo sapiens	68-72	
19400587-4	2009	Using temperature-controlled ES-MS, it is shown that the Stx1 and Stx2 holotoxins exhibit differences in their resistance to temperature- and acid-induced dissociation.	stichoposide	71-81	syntaxin 2	Homo sapiens	66-70	
16242986-3	2006	The purpose of the present study was to examine the cytotoxicity of Stx type 2 (Stx2 holotoxin) and its B subunit (Stx2 B subunit) on human renal tubular epithelial cells (HRTEC), in the presence and absence of inflammatory factors.	stichoposide	85-94	syntaxin 2	Homo sapiens	80-84	
16242986-5	2006	HRTEC are sensitive to both Stx2 holotoxin and Stx2 B subunit in a dose- and time-dependent manner.	stichoposide	33-42	syntaxin 2	Homo sapiens	28-32	
16242986-7	2006	The effects of Stx2 B subunit appear at doses higher than those used for Stx2 holotoxin.	stichoposide	78-87	syntaxin 2	Homo sapiens	15-21	
16242986-7	2006	The effects of Stx2 B subunit appear at doses higher than those used for Stx2 holotoxin.	stichoposide	78-87	syntaxin 2	Homo sapiens	15-19	
11133375-7	2001	Although their immune response to the Stx2 B subunit was variable, rabbits that developed Stx2 B subunit-specific antibodies, as determined by immunoblot and in vitro cytotoxicity neutralization assays, survived a challenge with Stx2 holotoxin.	stichoposide	234-243	syntaxin 2	Homo sapiens	90-96	
28398250-4	2017	Here, we compare the ribosome binding and depurination activity of Stx1 and Stx2 holotoxins with the A1 subunits of Stx1 and Stx2 using either the ribosome or a 10-mer RNA mimic of the sarcin/ricin loop as substrates.	stichoposide	81-91	syntaxin 2	Homo sapiens	76-80	
28398250-5	2017	Our results demonstrate that the active sites of Stx1 and Stx2 holotoxins are blocked by the A2 chain and the B subunit, while the ribosome binding sites are exposed to the solvent.	stichoposide	63-73	syntaxin 2	Homo sapiens	58-62	
28398250-6	2017	Unlike ricin, which is enzymatically active, but cannot interact with the ribosome, Stx1 and Stx2 holotoxins are enzymatically inactive but can interact with the ribosome.	stichoposide	98-108	syntaxin 2	Homo sapiens	93-97	
24983355-5	2014	Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids.	stichoposide	28-37	syntaxin 2	Homo sapiens	62-67	
24983355-5	2014	Here, we studied binding of holotoxin and B-subunits of Stx1, Stx2a, Stx2b, Stx2c and Stx2d to glycolipid receptors globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) in the presence of cell membrane components such as phosphatidylcholine (PC), cholesterol (Ch) and other neutral glycolipids.	stichoposide	28-37	syntaxin 2	Homo sapiens	69-74	
24983355-6	2014	In the absence of PC and Ch, holotoxins of Stx2 variants bound to mixtures of Gb3 with other glycolipids but not to Gb3 or Gb4 alone.	stichoposide	29-39	syntaxin 2	Homo sapiens	43-47