PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29075122-0 2017 Adeno-associated virus-mediated neuroglobin overexpression ameliorates the N-methyl-N-nitrosourea-induced retinal impairments: a novel therapeutic strategy against photoreceptor degeneration. Methylnitrosourea 75-97 neuroglobin Mus musculus 32-43 29075122-3 2017 The present study found the retinal neuroglobin (NGB) expression in the MNU-administered mice was significantly lower than in normal controls, suggesting NGB was correlated with RD. Methylnitrosourea 72-75 neuroglobin Mus musculus 36-47 29075122-3 2017 The present study found the retinal neuroglobin (NGB) expression in the MNU-administered mice was significantly lower than in normal controls, suggesting NGB was correlated with RD. Methylnitrosourea 72-75 neuroglobin Mus musculus 49-52 29075122-3 2017 The present study found the retinal neuroglobin (NGB) expression in the MNU-administered mice was significantly lower than in normal controls, suggesting NGB was correlated with RD. Methylnitrosourea 72-75 neuroglobin Mus musculus 154-157 29075122-4 2017 Subsequently, an adeno-associated virus (AAV)-2-mCMV-NGB vector was delivered into the subretinal space of the MNU-administered mice. Methylnitrosourea 111-114 neuroglobin Mus musculus 53-56 29075122-6 2017 Further, we found NGB overexpression could alleviate visual impairments and morphological devastations in MNU-administered mice. Methylnitrosourea 106-109 neuroglobin Mus musculus 18-21 29075122-7 2017 NGB overexpression could rectify apoptotic abnormalities and ameliorate oxidative stress in MNU-administered mice, thereby promoting photoreceptor survival. Methylnitrosourea 92-95 neuroglobin Mus musculus 0-3 29075122-8 2017 The cone photoreceptors in MNU-administered mice were also sensitive to AAV-mediated NGB overexpression. Methylnitrosourea 27-30 neuroglobin Mus musculus 85-88 29038003-4 2018 The retinal Ngb expression in MNU administered mice attenuated following a time dependent manner, suggesting Ngb was involved in the photoreceptor degeneration. Methylnitrosourea 30-33 neuroglobin Mus musculus 12-15 29038003-4 2018 The retinal Ngb expression in MNU administered mice attenuated following a time dependent manner, suggesting Ngb was involved in the photoreceptor degeneration. Methylnitrosourea 30-33 neuroglobin Mus musculus 109-112 29038003-5 2018 Conversely, the intravenous delivery of Hemin, a Ngb up-regulator, enhanced the Ngb expressions in the retinas of MNU administered mice. Methylnitrosourea 114-117 neuroglobin Mus musculus 49-52 29038003-5 2018 Conversely, the intravenous delivery of Hemin, a Ngb up-regulator, enhanced the Ngb expressions in the retinas of MNU administered mice. Methylnitrosourea 114-117 neuroglobin Mus musculus 80-83 29038003-10 2018 In conclusion, the intraperitoneally delivery of Hemin can enhance the Ngb expressions in the MNU administered retinas, thereby ameliorating the photoreceptor degeneration and associated visual impairments. Methylnitrosourea 94-97 neuroglobin Mus musculus 71-74