PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Sertraline	58-68	interleukin 6	Homo sapiens	344-357	
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Sertraline	58-68	interleukin 6	Homo sapiens	359-363	
19641491-5	2009	Levels of CRP and IL-6 also decreased after 20 weeks of sertraline treatment, whereas they did not significantly change in the placebo group.	Sertraline	56-66	interleukin 6	Homo sapiens	18-22	
31383995-0	2020	Sertraline treatment decreased the serum levels of interleukin-6 and high-sensitivity C-reactive protein in hematopoietic stem cell transplantation patients with depression; a randomized double-blind, placebo-controlled clinical trial.	Sertraline	0-10	interleukin 6	Homo sapiens	51-64	
25522414-8	2014	Unexpectedly, sertraline and DHA had pro-inflammatory effects, with sertraline increasing IFN-alpha and IL-6 and DHA increasing IL-15, IL-1RA, IFN-alpha, and IL-6, though these changes were also associated with a decrease in NF-kB activity, suggesting distinct modes of action.	Sertraline	68-78	interleukin 6	Homo sapiens	104-108	
24121064-0	2013	Sertraline decreases serum level of interleukin-6 (IL-6) in hemodialysis patients with depression: results of a randomized double-blind, placebo-controlled clinical trial.	Sertraline	0-10	interleukin 6	Homo sapiens	36-49	
24121064-0	2013	Sertraline decreases serum level of interleukin-6 (IL-6) in hemodialysis patients with depression: results of a randomized double-blind, placebo-controlled clinical trial.	Sertraline	0-10	interleukin 6	Homo sapiens	51-55	
24121064-1	2013	BACKGROUND: This study was designed to assess the effect of sertraline on serum concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), IL-10 and high-sensitivity C-reactive protein (hs-CRP) of depressed hemodialysis (HD) patients.	Sertraline	60-70	interleukin 6	Homo sapiens	98-111	
24121064-7	2013	Compared with placebo, serum levels of IL-6 significantly decreased (P<0.01) in the sertraline group at week 12 of the study.	Sertraline	87-97	interleukin 6	Homo sapiens	39-43	
24121064-12	2013	CONCLUSIONS: Compared with placebo, sertraline significantly decreased serum level of IL-6.	Sertraline	36-46	interleukin 6	Homo sapiens	86-90