PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29061958-11 2017 ALA (100 and 300 mg/kg) intervention to estrogen-deficiency induced bone loss mice (ovariectomized) showed reductions in TRAP+ osteoclasts count, CTX-I expression, levels of IL-1beta, IL-2, IL-6, IL10, TNF-alpha and MCP-1 and iNOS and COX-2. alpha-Linolenic Acid 0-3 interleukin 6 Mus musculus 190-194 30661600-8 2019 Cells incubated with ALA had a statistically significantly lower production of VEGF, RANTES, ICAM-1, MCP-1 and IL-6 compared to cells incubated without additional ALA. alpha-Linolenic Acid 21-24 interleukin 6 Mus musculus 111-115 30661600-10 2019 Cells incubated with low LA:ALA ratios had lower production of VEGF, RANTES, MCP-1 and IL-6 when compared with a LA:ALA ratio of 19:1. alpha-Linolenic Acid 28-31 interleukin 6 Mus musculus 87-91 30661600-11 2019 These findings suggest that a low LA:ALA ratio exerts anti-inflammatory effects by lowering the production VEGF, RANTES, ICAM-1, MCP-1 and IL-6 in TNF-alpha stimulated endothelial cells compared to a high ratio. alpha-Linolenic Acid 37-40 interleukin 6 Mus musculus 139-143 28017961-5 2017 Treatment with a omega-3 fatty acid alpha-linolenic acid (ALA, 50 mumol/L) produced moderate reduction in LPS-stimulated inflammatory cytokines and NO production (TNF-alpha and IL-6 were decreased by 46% and 42%, respectively). alpha-Linolenic Acid 36-56 interleukin 6 Mus musculus 177-181 28017961-5 2017 Treatment with a omega-3 fatty acid alpha-linolenic acid (ALA, 50 mumol/L) produced moderate reduction in LPS-stimulated inflammatory cytokines and NO production (TNF-alpha and IL-6 were decreased by 46% and 42%, respectively). alpha-Linolenic Acid 58-61 interleukin 6 Mus musculus 177-181 28017961-6 2017 Pre-incubation with Rb2 (1 or 10 mumol/L) for 12 h before ALA treatment dramatically amplified the inhibitory effects of ALA (TNF-alpha and IL-6 were decreased by 74% and 86%, respectively). alpha-Linolenic Acid 121-124 interleukin 6 Mus musculus 140-144 32084579-7 2020 ALA significantly inhibited the secretion of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) and increased anti-inflammatory cytokine. alpha-Linolenic Acid 0-3 interleukin 6 Mus musculus 122-135 9610840-0 1998 Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. alpha-Linolenic Acid 8-28 interleukin 6 Mus musculus 64-68 32084579-7 2020 ALA significantly inhibited the secretion of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) and increased anti-inflammatory cytokine. alpha-Linolenic Acid 0-3 interleukin 6 Mus musculus 137-141