PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19664246-6 2009 Therefore, this review will assess our current understanding of the differential effects of ALA, EPA and DHA on cancer, insulin resistance, and cardiovascular disease. alpha-Linolenic Acid 92-95 insulin Homo sapiens 120-127 20199997-4 2010 Through different mechanisms, some components of nuts such as magnesium, fiber, alpha-linolenic acid, L-arginine, antioxidants and MUFA may protect against inflammation and insulin resistance. alpha-Linolenic Acid 80-100 insulin Homo sapiens 173-180 20211645-0 2010 Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. alpha-Linolenic Acid 25-45 insulin Homo sapiens 71-78 15776817-6 2005 Linolenic acid (C18:3) produced greater permeability of insulin through epidermis than did other fatty acids during passive (44.45 x 10(-4) cm/h) and iontophoretic (78.03 x 10(-4) cm/h) transport. alpha-Linolenic Acid 0-14 insulin Homo sapiens 56-63 16571856-1 2006 OBJECTIVE: To assess whether dietary linolenic acid is associated with fasting insulin and glucose. alpha-Linolenic Acid 37-51 insulin Homo sapiens 79-86 16571856-5 2006 RESULTS: From the lowest to the highest sex-specific quartile of dietary linolenic acid, means +/- standard error for logarithmic transformed fasting insulin were 4.06 +/- 0.02 (reference), 4.09 +/- 0.02, 4.13 +/- 0.02, and 4.17 +/- 0.02 pM, respectively (trend, p < 0.0001), after adjustment for age, sex, energy intake, waist-to-hip ratio, smoking, and high-density lipoprotein-cholesterol. alpha-Linolenic Acid 73-87 insulin Homo sapiens 150-157 16571856-8 2006 DISCUSSION: Our data suggest that higher consumption of dietary linolenic acid is associated with higher plasma insulin, but not glucose levels, in non-diabetic subjects. alpha-Linolenic Acid 64-78 insulin Homo sapiens 112-119 15776817-7 2005 Lispro insulin flux was significantly (p<0.05) greater through linolenic acid and limonene pretreated epidermis compared to untreated controls during both passive and iontophoretic transports. alpha-Linolenic Acid 66-80 insulin Homo sapiens 7-14 8022751-6 1994 The addition of a mixture of 10 mM linoleic acid (18:2, omega 6) and 5 mM linolenic acid (18:3, omega 3), to basal glucose perifusate stimulated insulin secretion from a mean basal rate of 61 +/- 2 to 220 +/- 21 pg/islet/min (p < 0.001, n = 5). alpha-Linolenic Acid 74-88 insulin Homo sapiens 145-152 35537354-3 2022 The nutritionally essential precursors alpha-linolenic acid (C18:3n-3; ALA) and linoleic acid (C18:2n-6; LA) are subjected to desaturation by Delta6D/Delta5D desaturases and elongation by elongases 2/5, enzymes that are induced by insulin and repressed by PUFA. alpha-Linolenic Acid 39-59 insulin Homo sapiens 231-238 34791007-13 2022 CONCLUSION: ALA supplementation with camelina oil did not improve vascular function but adversely affected glucose metabolism in hypertensive patients with metabolic syndrome Whether this adverse effect on insulin sensitivity is related to gondoic acid enrichment, remains to be elucidated. alpha-Linolenic Acid 12-15 insulin Homo sapiens 206-213 27941179-4 2016 Alpha-linolenic acid consumption has a negative correlation with the insulin resistance, which in turn is negatively correlated with the remaining beta-cell function. alpha-Linolenic Acid 0-20 insulin Homo sapiens 69-76 33670720-1 2021 Alpha-linolenic acid (ALA), docosahexaenoic acid (DHA), rumenic acid (RmA), and punicic acid (PunA) are claimed to influence several physiological functions including insulin sensitivity, lipid metabolism and inflammatory processes. alpha-Linolenic Acid 0-20 insulin Homo sapiens 167-174 33670720-1 2021 Alpha-linolenic acid (ALA), docosahexaenoic acid (DHA), rumenic acid (RmA), and punicic acid (PunA) are claimed to influence several physiological functions including insulin sensitivity, lipid metabolism and inflammatory processes. alpha-Linolenic Acid 22-25 insulin Homo sapiens 167-174 32832007-4 2020 In the current study, we investigated whether alpha-linolenic acid (ALA), as a natural product, would increase insulin and IGF-I (insulin-like growth factor I) release from astrocytes. alpha-Linolenic Acid 46-66 insulin Homo sapiens 111-118 32832007-4 2020 In the current study, we investigated whether alpha-linolenic acid (ALA), as a natural product, would increase insulin and IGF-I (insulin-like growth factor I) release from astrocytes. alpha-Linolenic Acid 68-71 insulin Homo sapiens 111-118 32832007-6 2020 The results showed that ALA induced insulin and IGF-I secretion from astrocytes. alpha-Linolenic Acid 24-27 insulin Homo sapiens 36-43 30871233-14 2019 Our findings demonstrate that, in the context of a low-fat vegan diet, decreased intake of saturated and trans fats and increased relative content of polyunsaturated fatty acids, particularly linoleic and alpha-linolenic acids, are associated with decreased fat mass and insulin resistance, and enhanced insulin secretion. alpha-Linolenic Acid 205-226 insulin Homo sapiens 271-278 25933493-0 2015 Supplementation of alpha-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes. alpha-Linolenic Acid 19-39 insulin Homo sapiens 78-85 26912497-0 2016 Adipose tissue alpha-linolenic acid is inversely associated with insulin resistance in adults. alpha-Linolenic Acid 15-35 insulin Homo sapiens 65-72 26912497-8 2016 CONCLUSIONS: Higher adipose tissue ALA was inversely associated with insulin resistance in this cohort of healthy adult men and women. alpha-Linolenic Acid 35-38 insulin Homo sapiens 69-76 23648351-0 2013 [Alpha-linolenic acid improves insulin sensitivity in obese patients]. alpha-Linolenic Acid 1-21 insulin Homo sapiens 31-38 23648351-1 2013 OBJECTIVE: To explore the effects of alpha-linolenic acid on insulin sensitivity in obese patients. alpha-Linolenic Acid 37-57 insulin Homo sapiens 61-68 23648351-9 2013 CONCLUSION: alpha-linolenic acid increases peripheral insulin sensitivity in obese patients and it may aid the prevention and treatment of type 2 diabetes mellitus and atherosclerotic vascular diseases. alpha-Linolenic Acid 12-32 insulin Homo sapiens 54-61 23053988-4 2012 Insulin (1 muM) alone or co-treated with ALA improved IGF-I secretion and the expression of IGFBP3 mRNA, but decreased IGFBP1 mRNA versus appropriate control across ALA. Insulin also up-regulated the expression of GHR, IR, IGFBP3, and IGFBP4 mRNAs, and tended to prevent the transcript levels of IGF-I and IGFBP4 improved by ALA. alpha-Linolenic Acid 165-168 insulin Homo sapiens 0-7 23053988-1 2012 The main purposes of this study were to investigate the effects of alpha-linolenic acid (ALA) on the insulin-like growth factor (IGF) system of porcine primary hepatocytes with or without growth hormone (GH) or insulin and the potential role of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha/gamma) pathway. alpha-Linolenic Acid 67-87 insulin Homo sapiens 101-108 23053988-1 2012 The main purposes of this study were to investigate the effects of alpha-linolenic acid (ALA) on the insulin-like growth factor (IGF) system of porcine primary hepatocytes with or without growth hormone (GH) or insulin and the potential role of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha/gamma) pathway. alpha-Linolenic Acid 89-92 insulin Homo sapiens 101-108 23053988-4 2012 Insulin (1 muM) alone or co-treated with ALA improved IGF-I secretion and the expression of IGFBP3 mRNA, but decreased IGFBP1 mRNA versus appropriate control across ALA. Insulin also up-regulated the expression of GHR, IR, IGFBP3, and IGFBP4 mRNAs, and tended to prevent the transcript levels of IGF-I and IGFBP4 improved by ALA. alpha-Linolenic Acid 41-44 insulin Homo sapiens 0-7 23053988-4 2012 Insulin (1 muM) alone or co-treated with ALA improved IGF-I secretion and the expression of IGFBP3 mRNA, but decreased IGFBP1 mRNA versus appropriate control across ALA. Insulin also up-regulated the expression of GHR, IR, IGFBP3, and IGFBP4 mRNAs, and tended to prevent the transcript levels of IGF-I and IGFBP4 improved by ALA. alpha-Linolenic Acid 41-44 insulin Homo sapiens 170-177