PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16169525-4 2005 In addition, LA, ALA, and DHA decreased IL-6, IL-1beta, and TNFalpha gene expression (P < 0.05 for all) and nuclear factor (NF)-kappaB DNA-binding activity, whereas peroxisome proliferator-activated receptor-gamma (PPARgamma) DNA-binding activity was increased. alpha-Linolenic Acid 17-20 interleukin 6 Homo sapiens 40-44 29698923-4 2018 We find that ALA treatment leads to a reduction in lipopolysaccharide (LPS)-induced interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha production. alpha-Linolenic Acid 13-16 interleukin 6 Homo sapiens 108-144 35563819-10 2022 The infiltration of T cells into the epidermis was reduced when ALA was added to the culture medium, and significant decreases in the levels of inflammatory cytokines and chemokines such as CXCL1, interleukin-6 (IL-6) and interleukin-8 (IL-8) were consequently measured in psoriatic substitutes supplemented with this n-3 PUFA. alpha-Linolenic Acid 64-67 interleukin 6 Homo sapiens 197-210 35563819-10 2022 The infiltration of T cells into the epidermis was reduced when ALA was added to the culture medium, and significant decreases in the levels of inflammatory cytokines and chemokines such as CXCL1, interleukin-6 (IL-6) and interleukin-8 (IL-8) were consequently measured in psoriatic substitutes supplemented with this n-3 PUFA. alpha-Linolenic Acid 64-67 interleukin 6 Homo sapiens 212-216 31245005-10 2019 Conversely, women with high palmitoleic, oleic, and linolenic acid levels had reduced odds (>=2-fold, p<0.01 to p<0.001) for having higher IL-8, IL-6 or tumor necrosis factor-alpha levels. alpha-Linolenic Acid 52-66 interleukin 6 Homo sapiens 145-149 15678256-6 2005 In addition, ALA supplementation resulted in a significant decrease in the serum concentration of serum amyloid A (SAA) (p=0.014), C-reactive protein (CRP) (p=0.013), macrophage colony-stimulating factor (MCSF) (p<0.001), and interleukin (IL)-6 (p=0.028). alpha-Linolenic Acid 13-16 interleukin 6 Homo sapiens 229-247 15226473-5 2004 The intake of alpha-linolenic acid was inversely related to plasma concentrations of CRP (beta = -0.55, P = 0.02), Il-6 (beta = -0.36, P = 0.01), and E-selectin (beta = -0.24, P = 0.008) after controlling for age, BMI, physical activity, smoking status, alcohol consumption, and intake of linoleic acid (n-6) and saturated fat. alpha-Linolenic Acid 14-34 interleukin 6 Homo sapiens 115-119 12818406-0 2003 Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. alpha-Linolenic Acid 8-28 interleukin 6 Homo sapiens 79-92 12818406-9 2003 RESULTS: Dietary supplementation with ALA decreased significantly CRP, SAA and IL-6 levels. alpha-Linolenic Acid 38-41 interleukin 6 Homo sapiens 79-83 12818406-13 2003 CONCLUSIONS: Dietary supplementation with ALA for 3 months decreases significantly CRP, SAA and IL-6 levels in dyslipidaemic patients. alpha-Linolenic Acid 42-45 interleukin 6 Homo sapiens 96-100 10416955-5 1999 IL-6 is released by a range of tissues in response to stimulation by the monocyte-derived cytokines interleukin-1 and tumor necrosis factor; by suppressing production of these cytokines, fish oil, alpha-linolenic acid, and pentoxifylline can reduce IL-6 synthesis. alpha-Linolenic Acid 197-217 interleukin 6 Homo sapiens 0-4 20463041-7 2010 RESULTS: A 1-g increment in habitual dietary ALA intake was associated with 11.0% lower concentrations of sIL-6R (P = 0.004) but not of IL-6 (P = 0.31), TNF-alpha (P = 0.16), or hsCRP (P = 0.36) after adjustment for energy intake, nutritional factors, known cardiovascular disease risk factors, and medications. alpha-Linolenic Acid 45-48 interleukin 6 Homo sapiens 107-111 29107850-5 2018 The increase of interleukin-6 during the 24h after implantation was associated with higher levels of pentadecanoic acid (C15:0) and lower levels of alpha-linolenic acid (C18:3 N3). alpha-Linolenic Acid 148-168 interleukin 6 Homo sapiens 16-29 26912161-7 2016 RESULTS: ALA significantly decreased plasma TG, FFA, glycerol, IL-6, and TNF-alpha levels and increased the mRNA expression levels of PPAR-gamma, G0S2, and GPR120 in PBMC, compared with the untreated control group. alpha-Linolenic Acid 9-12 interleukin 6 Homo sapiens 63-67 20463041-8 2010 After further control for shared genetic and common environmental factors by comparison of brothers within a twin pair, a twin with a 1-g higher ALA intake was likely to have 10.9% (95% CI: 3.7%, 17.6%; P = 0.004) lower sIL-6R concentrations than his co-twin with a low intake, whereas ALA intake was not significantly associated with plasma concentrations of IL-6, TNF-alpha, or hsCRP. alpha-Linolenic Acid 145-148 interleukin 6 Homo sapiens 221-225 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. alpha-Linolenic Acid 74-94 interleukin 6 Homo sapiens 165-169 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. alpha-Linolenic Acid 96-99 interleukin 6 Homo sapiens 165-169 17284733-7 2007 RESULTS: IL-6, IL-1beta, and TNF-alpha production by PBMCs and serum TNF-alpha concentrations were lower (P < 0.05 and P < 0.08, respectively) with the ALA diet than with the LA diet or AAD. alpha-Linolenic Acid 158-161 interleukin 6 Homo sapiens 9-13 19234585-2 2009 The purpose of this study was to evaluate the effects of supplementing older adults with alpha-linolenic acid (ALA) during a resistance training program, based on the hypothesis that ALA decreases the plasma concentration of the inflammatory cytokine tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, which in turn would improve muscle size and strength. alpha-Linolenic Acid 89-109 interleukin 6 Homo sapiens 289-307 19234585-2 2009 The purpose of this study was to evaluate the effects of supplementing older adults with alpha-linolenic acid (ALA) during a resistance training program, based on the hypothesis that ALA decreases the plasma concentration of the inflammatory cytokine tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, which in turn would improve muscle size and strength. alpha-Linolenic Acid 183-186 interleukin 6 Homo sapiens 289-307 19234585-5 2009 Males supplementing with ALA decreased IL-6 concentration over the 12 weeks (62 +/- 36% decrease; p = 0.003), with no other changes in inflammatory cytokines. alpha-Linolenic Acid 25-28 interleukin 6 Homo sapiens 39-43 19234585-8 2009 ALA supplementation lowers the IL-6 concentration in older men but not women, but had minimal effect on muscle mass and strength during resistance training. alpha-Linolenic Acid 0-3 interleukin 6 Homo sapiens 31-35 17284733-10 2007 CONCLUSIONS: Increased intakes of dietary ALA elicit antiinflammatory effects by inhibiting IL-6, IL-1beta, and TNF-alpha production in cultured PBMCs. alpha-Linolenic Acid 42-45 interleukin 6 Homo sapiens 92-96