PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29061958-0 2017 alpha-Linolenic Acid Inhibits Receptor Activator of NF-kappaB Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF-kappaB-iNOS) Signaling Pathways. alpha-Linolenic Acid 0-20 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 78-83 29061958-3 2017 We investigated the effect of alpha-linolenic acid (ALA) on RANKL-stimulated osteoclast differentiation, LPS-induced and ovariectomized bone loss in mice models. alpha-Linolenic Acid 52-55 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 60-65 29061958-6 2017 RESULTS ALA intervention inhibited RANKL-induced osteoclasts proliferation and differentiation. alpha-Linolenic Acid 8-11 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 35-40 29061958-8 2017 ALA suppressed the RANKL-induced osteoclast markers c-Fos, c-Jun and NFATc1 together with transcription factor proteins TRAP, OSCAR, cathepsin K and beta3-integrin. alpha-Linolenic Acid 0-3 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 19-24 29061958-9 2017 ALA also suppressed the RANKL-stimulated phosphorylation of JNK, ERK, and AKT as well as NF-kappaB and BCL-2 proteins. alpha-Linolenic Acid 0-3 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 24-29 29061958-12 2017 CONCLUSIONS ALA suppresses RANKL-induced osteoclast differentiation and prevents inflammatory bone loss via downregulation of NF-kappaB-iNOS-COX-2 signaling. alpha-Linolenic Acid 12-15 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 27-32