PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24348338-7 2013 Finally, we locally injected the GABAA agonist Muscimol into layer CA1 of the hippocampus while simultaneously recording somatic activity and SDWs on the same tetrodes. Muscimol 47-55 carbonic anhydrase 1 Rattus norvegicus 67-70 31981675-6 2020 The microinjection of a GABA-A receptor agonist, muscimol (0.01-0.03 microg/rat) into the CA1 region increased the response of an ineffective dose of morphine (0.5 mg/kg, i.p.) Muscimol 49-57 carbonic anhydrase 1 Rattus norvegicus 90-93 31981675-11 2020 It should be noted that the intra-CA1 microinjection of muscimol, intra-BLA microinjection of WIN55,212-2 or AM251 alone could not affect memory consolidation. Muscimol 56-64 carbonic anhydrase 1 Rattus norvegicus 34-37 24710315-4 2014 An intra-CA1 injection of (+)-MK-801 (2 mug/rat) and muscimol (0.5 mug/rat; a GABAA receptor agonist) increased %OAT and %OAE by themselves while not altering the closed arm entries, indicating an anxiolytic-like effect of these drugs. Muscimol 53-61 carbonic anhydrase 1 Rattus norvegicus 9-12 24710315-7 2014 The isobologram analysis of these findings suggested a synergistic anxiety-like effect of intra-CA1 (+)-MK-801 and muscimol. Muscimol 115-123 carbonic anhydrase 1 Rattus norvegicus 96-99 24342568-4 2014 Additionally, a low dose of the GABAA agonist muscimol was used to temporarily inactivate CA1 to observe its effect in extinction. Muscimol 46-54 carbonic anhydrase 1 Rattus norvegicus 90-93 24342568-6 2014 Moreover, muscimol infused into CA1 before extinction training resulted in impaired extinction and down-regulation of NR2B activity and phosphorylated GluR1 (at Ser845) in CA1, and the expression levels of NR2B and GluR1 were decreased significantly in the basolateral amygdala (BLA). Muscimol 10-18 carbonic anhydrase 1 Rattus norvegicus 32-35 24342568-6 2014 Moreover, muscimol infused into CA1 before extinction training resulted in impaired extinction and down-regulation of NR2B activity and phosphorylated GluR1 (at Ser845) in CA1, and the expression levels of NR2B and GluR1 were decreased significantly in the basolateral amygdala (BLA). Muscimol 10-18 carbonic anhydrase 1 Rattus norvegicus 172-175 2792064-2 1989 Quantitative film autoradiography was used to study muscimol binding in the CA1 region and 3 other brain areas (dentate gyrus, cerebral cortex, and thalamus). Muscimol 52-60 carbonic anhydrase 1 Rattus norvegicus 76-79 32471158-6 2020 Our findings show that BLA GABAAR activation via muscimol mimicked the previously reported effects of electrical BLA priming on LTP in the perforant path and the ventral hippocampal commissure-CA1 pathways, decreasing CA1 LTP and increasing DG LTP. Muscimol 49-57 carbonic anhydrase 1 Rattus norvegicus 193-196 32471158-6 2020 Our findings show that BLA GABAAR activation via muscimol mimicked the previously reported effects of electrical BLA priming on LTP in the perforant path and the ventral hippocampal commissure-CA1 pathways, decreasing CA1 LTP and increasing DG LTP. Muscimol 49-57 carbonic anhydrase 1 Rattus norvegicus 218-221 32471158-7 2020 Furthermore, muscimol application before or after tetanic stimulation of the ventral hippocampal commissure-CA1 pathways attenuated the BLA priming-induced decrease in CA1 LTP. Muscimol 13-21 carbonic anhydrase 1 Rattus norvegicus 108-111 32471158-7 2020 Furthermore, muscimol application before or after tetanic stimulation of the ventral hippocampal commissure-CA1 pathways attenuated the BLA priming-induced decrease in CA1 LTP. Muscimol 13-21 carbonic anhydrase 1 Rattus norvegicus 168-171 28843666-4 2017 We performed bilateral inactivation of dorsal CA1 with the GABAA agonist muscimol previously to the task. Muscimol 73-81 carbonic anhydrase 1 Rattus norvegicus 46-49 21925239-4 2011 Post-training intra-CA1 administration of a GABA-A receptor agonist, muscimol (0.01-0.02 mug/rat) dose-dependently impaired memory retrieval. Muscimol 69-77 carbonic anhydrase 1 Rattus norvegicus 20-23 23438692-7 2013 Pre-training intra-CA1 microinjection of muscimol, a GABA-A receptor agonist, at the dose of 0.01 or 0.02mug/rat, increased the traveled distance or the escape latency and traveled distance to the hidden platform, respectively, indicating a water maze spatial acquisition impairment. Muscimol 41-49 carbonic anhydrase 1 Rattus norvegicus 19-22 22909986-3 2012 The results showed that pre-training intra-MS/CA1 administration of nonselective muscarinic Ach antagonist, scopolamine (0.5, 1 and 2 mug/rat) and GABA(A) receptor agonist, muscimol (0.01 and 0.02 mug/rat) impaired, while acetylcholinesterase inhibitor, physostigmine (0.5 and 1 mug/rat) and GABA(A) receptor antagonist, bicuculline (0.25 mug/rat) improved memory acquisition. Muscimol 173-181 carbonic anhydrase 1 Rattus norvegicus 46-49 22909986-4 2012 Moreover, intra-CA1/MS administration of a subthreshold dose of muscimol or bicuculline increased and reversed the impairment induced by scopolamine in MS/CA1 respectively (cross injection). Muscimol 64-72 carbonic anhydrase 1 Rattus norvegicus 16-19 22909986-4 2012 Moreover, intra-CA1/MS administration of a subthreshold dose of muscimol or bicuculline increased and reversed the impairment induced by scopolamine in MS/CA1 respectively (cross injection). Muscimol 64-72 carbonic anhydrase 1 Rattus norvegicus 155-158 22909986-5 2012 Also, the result revealed that, intra-CA1/MS administration subthreshold dose of muscimol reduced improvement of memory induced by physostigmine in the MS/CA1, respectively (cross injection). Muscimol 81-89 carbonic anhydrase 1 Rattus norvegicus 38-41 22909986-5 2012 Also, the result revealed that, intra-CA1/MS administration subthreshold dose of muscimol reduced improvement of memory induced by physostigmine in the MS/CA1, respectively (cross injection). Muscimol 81-89 carbonic anhydrase 1 Rattus norvegicus 155-158 22546523-11 2012 Rats treated with muscimol in CA1 explored all the objects equally well, irrespective of place or presentation time. Muscimol 18-26 carbonic anhydrase 1 Rattus norvegicus 30-33 21925239-9 2011 Furthermore, the amnesic effect of intra-VTA administration of muscimol was significantly decreased by intra-CA1 administration of sulpiride (0.5 and 1 mug/rat, intra-CA1), but not SCH23390. Muscimol 63-71 carbonic anhydrase 1 Rattus norvegicus 109-112 21925239-9 2011 Furthermore, the amnesic effect of intra-VTA administration of muscimol was significantly decreased by intra-CA1 administration of sulpiride (0.5 and 1 mug/rat, intra-CA1), but not SCH23390. Muscimol 63-71 carbonic anhydrase 1 Rattus norvegicus 167-170 16624534-3 2007 Intra-CA1 administration of the GABA(A) receptor agonist, muscimol (0.25, 0.5 and 1 microg/rat) significantly inhibited the morphine (5 mg/kg, s.c.)-induced CPP. Muscimol 58-66 carbonic anhydrase 1 Rattus norvegicus 6-9 18410948-4 2008 The additive neuroprotection could be obtained in the hippocampal CA1 pyramidal cells prominently when muscimol and baclofen were co-applied. Muscimol 103-111 carbonic anhydrase 1 Rattus norvegicus 66-69 16624534-6 2007 Furthermore, the muscimol-induced inhibition of morphine response was reversed by bicuculline (1 microg/rat, intra-CA1) administration. Muscimol 17-25 carbonic anhydrase 1 Rattus norvegicus 115-118 16624534-7 2007 On the other hand, the bilateral intra-CA1 injections of muscimol (0.25, 0.5 and 1 microg/rat) or bicuculline (0.5, 1 and 2 microg/rat) significantly decreased the expression of morphine-induced CPP. Muscimol 57-65 carbonic anhydrase 1 Rattus norvegicus 39-42 17999204-8 2007 After knockdown, Ca2+ influx was suppressed as both NMDA and muscimol-stimulated Ca2+ permeability of the immature CA1 was blocked in ex-vivo slices measured with FURA-2AM optical dye imaging. Muscimol 61-69 carbonic anhydrase 1 Rattus norvegicus 115-118 15885255-4 2005 Although muscimol (GABA(A+)) (0.1, 0.5 and 1 microg/rat, intra-CA1) produced dose dependent increase in %OAT and a slight increase in %OAE, bicuculline (GABA(A-)), (1, 2 and 4 microg/rat, intra-CA1) failed to change the anxiety profile. Muscimol 9-17 carbonic anhydrase 1 Rattus norvegicus 63-66 15885255-4 2005 Although muscimol (GABA(A+)) (0.1, 0.5 and 1 microg/rat, intra-CA1) produced dose dependent increase in %OAT and a slight increase in %OAE, bicuculline (GABA(A-)), (1, 2 and 4 microg/rat, intra-CA1) failed to change the anxiety profile. Muscimol 9-17 carbonic anhydrase 1 Rattus norvegicus 194-197 12917381-0 2003 Different reactions of control and epileptic rats to administration of APV or muscimol on thalamic or CA3-induced CA1 responses. Muscimol 78-86 carbonic anhydrase 1 Rattus norvegicus 114-117 12917381-8 2003 The duration of the PSP as well as the amplitude and number of spikes were reduced by administration of APV or muscimol into CA1 in both control and epileptic rats. Muscimol 111-119 carbonic anhydrase 1 Rattus norvegicus 125-128 9832927-4 1998 STM was unaffected by any of the treatments given into PRE, and was inhibited by CNQX or muscimol given into CA1, PP and EC and by scopolamine given into PP, and enhanced by SCH given into CA1. Muscimol 89-97 carbonic anhydrase 1 Rattus norvegicus 109-112 12781999-10 2003 In the current experiment, we documented that muscimol exposure on postnatal days 0 and 1 leads to fewer neurons in the male and female rat hippocampus (CA1, CA2/3, and dentate gyrus) on postnatal day 21. Muscimol 46-54 carbonic anhydrase 1 Rattus norvegicus 153-156 12617940-6 2003 Muscimol given 30 min before killing significantly increased the number of neurons exhibiting phosphorylated cyclic AMP response element binding protein in newborn male hypothalamus and CA1 hippocampus but decreased phosphorylated cyclic AMP response element binding protein in most brain regions in females. Muscimol 0-8 carbonic anhydrase 1 Rattus norvegicus 186-189 11222088-4 2001 While bath application of muscimol, DZP, or baclofen suppressed spontaneous activity in CA1 neurons not previously exposed to TMPP, subsequent application of TMPP (10 microM) reversed the actions of muscimol and diazepam, but not baclofen. Muscimol 26-34 carbonic anhydrase 1 Rattus norvegicus 88-91 10828527-6 2000 Muscimol injection to the supramammillary nucleus prevented Fos expression in the CA1-CA3 region and reduced that in the forebrain regions with the latest Fos expression, but did not affect Fos expression in other forebrain regions with early Fos expression. Muscimol 0-8 carbonic anhydrase 1 Rattus norvegicus 82-85 9779197-9 1998 When hypoxia was combined with CHI, significant increase in [3H] GLU binding to NMDA receptors and significant decrease in [3H]-muscimol binding to GABAA receptors were observed in CA1 and CA3 at 1 h and 24 h post-insult. Muscimol 128-136 carbonic anhydrase 1 Rattus norvegicus 181-184 9042566-6 1997 Treatment with 1 mg/kg muscimol led to further significant decreases of Fos expression in CA1-3 pyramidal neurons and the disappearance of Fos induction in the cerebral cortex above the rhinal fissure, reticular thalamic nucleus, claustrum, fundus striati, ventral pallidum, septal nucleus, lateral habenular nucleus, and lateral amygdaloid nucleus. Muscimol 23-31 carbonic anhydrase 1 Rattus norvegicus 90-93 9166743-3 1997 We have shown previously that muscimol-evoked 36Cl- efflux and paired-pulse inhibition (involving GABA(A)-mediated recurrent inhibition) were decreased persistently in the CA1 region of hippocampal slices from chronic intermittent ethanol (CIE)-treated rats. Muscimol 30-38 carbonic anhydrase 1 Rattus norvegicus 172-175 9409710-9 1997 Muscimol (100 microM) produced either depolarizing or hyperpolarizing effects on Vm with an input resistance decrease in CA1-PCs, and it depolarized Vm with an input resistance decrease in DG-GCs. Muscimol 0-8 carbonic anhydrase 1 Rattus norvegicus 121-124 8590044-4 1995 In hippocampal slices, muscimol (50 microM)-evoked 36Cl- efflux was higher in CA1 (112.5 +/- 27.9% above basal efflux rate) than in DG slices (29.7 +/- 5.6%). Muscimol 23-31 carbonic anhydrase 1 Rattus norvegicus 78-81 8590044-5 1995 In the presence of ZnCl2, the muscimol effect on efflux rate in CA1 and DG regions was decreased to 10.6 +/- 5.4% and 6.9 +/- 4.9%, respectively. Muscimol 30-38 carbonic anhydrase 1 Rattus norvegicus 64-67 7760041-1 1995 Muscimol-stimulated radiotracer 36CI- uptake in synaptoneurosomes was used to investigate the function of the GABAA receptor complex in the CA1-3 area and fascia dentata (granular and molecular layers and hilus) of rats kindled by stimulation, twice a day, of the Schaffer collateral fibers. Muscimol 0-8 carbonic anhydrase 1 Rattus norvegicus 140-143 7760041-4 1995 In FK animals, the muscimol-stimulated 36CI- uptake was significantly reduced by 21% in the CA1-3 area in comparison with nonstimulated controls, whereas a significant increase of 29% was found in the fascia dentata. Muscimol 19-27 carbonic anhydrase 1 Rattus norvegicus 92-97 7760041-6 1995 The observed changes in muscimol-stimulated 36CI- uptake at the FK stage closely parallel the recently observed changes in [3H]muscimol binding in the CA1 area and fascia dentata. Muscimol 24-32 carbonic anhydrase 1 Rattus norvegicus 151-154 7760041-6 1995 The observed changes in muscimol-stimulated 36CI- uptake at the FK stage closely parallel the recently observed changes in [3H]muscimol binding in the CA1 area and fascia dentata. Muscimol 127-135 carbonic anhydrase 1 Rattus norvegicus 151-154 8058123-4 1994 In the fully kindled group, the binding over the complete range of tested [3H]muscimol concentrations was significantly increased by 30-50% in the fascia dentata, while the binding was significantly decreased by 10-25% in the CA1 area. Muscimol 78-86 carbonic anhydrase 1 Rattus norvegicus 226-229 8353606-2 1993 The GABA-evoked change of [Ca]i was mimicked by muscimol and not by baclofen, but was only minimally affected by picrotoxin or bicuculline, indicating that this effect of GABA is not likely to be mediated by activation of GABAB receptor or by a conventional chloride-linked GABAA receptor. Muscimol 48-56 carbonic anhydrase 1 Rattus norvegicus 27-31