PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14520599-4 2003 It is suggested that suppression of GnRH/LH release under muscimol treatment may result from activation of GABAA receptors on GnRH nerve terminals and through GABAA receptor mechanism activated beta-endorphinergic and dopaminergic neurons in the VEN/NI. Muscimol 58-66 gonadotropin releasing hormone 1 Homo sapiens 36-40 23719807-7 2013 Whereas the GABAA receptor agonist muscimol evoked excitatory, inhibitory, or mixed effects on GnRH neuron firing, the GABAA receptor antagonist picrotoxin resulted in a consistent suppression of firing. Muscimol 35-43 gonadotropin releasing hormone 1 Homo sapiens 95-99 18434046-1 2009 The effect of prolonged, intermittent infusion of GABA(A) receptor agonist (muscimol) or GABA(A) receptor antagonist (bicuculline) into the third cerebral ventricle on the expression of GnRH gene and GnRH-R gene in the hypothalamus and GnRH-R gene in the anterior pituitary gland was examined in follicular-phase ewes by real-time PCR. Muscimol 76-84 gonadotropin releasing hormone 1 Homo sapiens 186-190 18434046-4 2009 The decrease or increase of GnRH-R mRNA in the anterior pituitary gland and LH secretion in the muscimol- or bicuculline-treated ewes, respectively, is probably a consequence of parallel changes in the release of GnRH from the hypothalamus activating GnRH-R gene expression. Muscimol 96-104 gonadotropin releasing hormone 1 Homo sapiens 28-32 14520599-4 2003 It is suggested that suppression of GnRH/LH release under muscimol treatment may result from activation of GABAA receptors on GnRH nerve terminals and through GABAA receptor mechanism activated beta-endorphinergic and dopaminergic neurons in the VEN/NI. Muscimol 58-66 gonadotropin releasing hormone 1 Homo sapiens 126-130 10718911-9 2000 When cells were pretreated with muscimol this increased the spike phase of the [Ca2+]i response to subsequent stimulation with gonadotropin-releasing hormone (GnRH). Muscimol 32-40 gonadotropin releasing hormone 1 Homo sapiens 127-157 12654529-5 2003 The suppressive influence of muscimol in the MPOA on GnRH release might be considered a net result of its direct inhibitory effect on GnRH release, indirect inhibitory influence on GnRH release through activation of the beta-endorphinergic system, and facilitation of GnRH neurons by increasing noradrenaline release. Muscimol 29-37 gonadotropin releasing hormone 1 Homo sapiens 53-57 12654529-5 2003 The suppressive influence of muscimol in the MPOA on GnRH release might be considered a net result of its direct inhibitory effect on GnRH release, indirect inhibitory influence on GnRH release through activation of the beta-endorphinergic system, and facilitation of GnRH neurons by increasing noradrenaline release. Muscimol 29-37 gonadotropin releasing hormone 1 Homo sapiens 134-138 12654529-5 2003 The suppressive influence of muscimol in the MPOA on GnRH release might be considered a net result of its direct inhibitory effect on GnRH release, indirect inhibitory influence on GnRH release through activation of the beta-endorphinergic system, and facilitation of GnRH neurons by increasing noradrenaline release. Muscimol 29-37 gonadotropin releasing hormone 1 Homo sapiens 134-138 12654529-5 2003 The suppressive influence of muscimol in the MPOA on GnRH release might be considered a net result of its direct inhibitory effect on GnRH release, indirect inhibitory influence on GnRH release through activation of the beta-endorphinergic system, and facilitation of GnRH neurons by increasing noradrenaline release. Muscimol 29-37 gonadotropin releasing hormone 1 Homo sapiens 134-138 10718911-9 2000 When cells were pretreated with muscimol this increased the spike phase of the [Ca2+]i response to subsequent stimulation with gonadotropin-releasing hormone (GnRH). Muscimol 32-40 gonadotropin releasing hormone 1 Homo sapiens 159-163 10718911-10 2000 Similar amplification was seen in muscimol-pretreated cells stimulated with GnRH in Ca2+-free medium, but not when cells were pretreated with muscimol in Ca2+-free medium. Muscimol 34-42 gonadotropin releasing hormone 1 Homo sapiens 76-80 9713333-9 1998 To substantiate the involvement of the GABAA receptor further, we tested the effects of muscimol, a selective agonist for this receptor, which suppressed GnRH release. Muscimol 88-96 gonadotropin releasing hormone 1 Homo sapiens 154-158 10095042-0 1999 Concentration-dependent effects of muscimol to enhance pulsatile GnRH release from GT1-7 neurons in vitro. Muscimol 35-43 gonadotropin releasing hormone 1 Homo sapiens 65-69 10095042-1 1999 Immortalized GT1-7 neurons were used to characterize the effect of muscimol, a GABAA receptor agonist, to enhance pulsatile gonadotropin-releasing hormone (GnRH) release. Muscimol 67-75 gonadotropin releasing hormone 1 Homo sapiens 124-154 10095042-1 1999 Immortalized GT1-7 neurons were used to characterize the effect of muscimol, a GABAA receptor agonist, to enhance pulsatile gonadotropin-releasing hormone (GnRH) release. Muscimol 67-75 gonadotropin releasing hormone 1 Homo sapiens 156-160 10095042-8 1999 Our results also demonstrated that the GABAA receptor agonist, muscimol, enhances pulsatile GnRH release from GT1-7 neurons in culture. Muscimol 63-71 gonadotropin releasing hormone 1 Homo sapiens 92-96 10095042-10 1999 The effects of 5 microM muscimol to increase GnRH pulsatility were blocked by co-exposure to the GABAA receptor antagonist, bicuculline. Muscimol 24-32 gonadotropin releasing hormone 1 Homo sapiens 45-49 10095042-12 1999 GnRH pulse amplitude (mean-area for each pulse) was increased during exposure to muscimol but not during the pre- or post-muscimol periods. Muscimol 81-89 gonadotropin releasing hormone 1 Homo sapiens 0-4 2544412-4 1989 Both GABA and muscimol at different concentrations induced an increase in LHRH release, but did not affect the release of arginine vasopressin and oxytocin. Muscimol 14-22 gonadotropin releasing hormone 1 Homo sapiens 74-78 2544412-6 1989 Muscimol-stimulated LHRH release was not affected by the presence of phentolamine, suggesting that the stimulatory effect of GABA-A receptors on LHRH release is not mediated by interactions with the noradrenergic system. Muscimol 0-8 gonadotropin releasing hormone 1 Homo sapiens 20-24 2544412-6 1989 Muscimol-stimulated LHRH release was not affected by the presence of phentolamine, suggesting that the stimulatory effect of GABA-A receptors on LHRH release is not mediated by interactions with the noradrenergic system. Muscimol 0-8 gonadotropin releasing hormone 1 Homo sapiens 145-149 2544412-7 1989 PGE2 has been shown to be a potent secretagogue of LHRH from the median eminence in vitro, and in this model the stimulatory effect of PGE2 was enhanced by muscimol. Muscimol 156-164 gonadotropin releasing hormone 1 Homo sapiens 51-55