PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33764366-11	2021	In summary, our results showed that nab-paclitaxel increased the expression of CCL26 in CAFs, and CCL26 enhanced the invasive potential of pancreatic cancer cells by activating the PI3K/AKT/mTOR axis.	nab	36-39	AKT serine/threonine kinase 1	Homo sapiens	186-189	
18455826-6	2008	However, blocking Akt activity by expressing its dominant negative form remarkably promoted NaB and GCV-mediated cytotoxicity via a thymidine kinase (TK)-independent mechanism.	nab	92-95	AKT serine/threonine kinase 1	Homo sapiens	18-21	
18455826-8	2008	These results suggest that interfering with either the Akt or MEKK1 signaling pathway may be a useful therapeutic strategy to increase the sensitivity of EBV-positive tumor cells to the combination of NaB and GCV.	nab	201-204	AKT serine/threonine kinase 1	Homo sapiens	55-58	
31836471-9	2020	Moreover, the PI3K/Akt/mTOR pathway was significantly inhibited and cell apoptosis was activated by NaB.	nab	100-103	AKT serine/threonine kinase 1	Homo sapiens	19-22	
31836471-11	2020	Collectively, NaB causes alpha-Synuclein degradation by an Atg5-dependent and PI3K/Akt/mTOR-related autophagy pathway.	nab	14-17	AKT serine/threonine kinase 1	Homo sapiens	83-86	
23696823-9	2013	Pharmacological studies and siRNA knockdown experiments showed that NaB-mediated AMPK activation induced the phosphorylation and nuclear translocation of Sirtuin 1, leading to the increased assembly of mammalian TOR complex 2 and phosphorylation of AKT at Ser473 and subsequent induction of Nrf2 expression and activation.	nab	68-71	AKT serine/threonine kinase 1	Homo sapiens	249-252	
33897442-14	2021	In conclusion, NaB could attenuate OA progression by restoring impaired autophagy and autophagic flux via the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway, both in vitro and in vivo, implying that NaB could represent a novel therapeutic approach for OA.	nab	15-18	AKT serine/threonine kinase 1	Homo sapiens	161-164