PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32555166-13 2020 In conclusion, we demonstrated that NaB prevents excessive ROS through NOX2 suppression and SOD1 upregulation by p21/NRF2 pathway, which is critical for inhibiting BACE1-dependent amyloidogenesis in neuronal cells exposed to high cholesterol environment. nab 36-39 H3 histone pseudogene 16 Homo sapiens 113-116 32555166-10 2020 We demonstrated that NaB increased the expression levels of p21 under high cholesterol, contributing to p21/NRF2 (Nuclear factor erythroid 2-related factor 2) colocalization, which leads to NRF2 stabilization. nab 21-24 H3 histone pseudogene 16 Homo sapiens 60-63 32555166-10 2020 We demonstrated that NaB increased the expression levels of p21 under high cholesterol, contributing to p21/NRF2 (Nuclear factor erythroid 2-related factor 2) colocalization, which leads to NRF2 stabilization. nab 21-24 H3 histone pseudogene 16 Homo sapiens 104-107 16800929-5 2006 NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone. nab 0-3 H3 histone pseudogene 16 Homo sapiens 146-149 16800929-5 2006 NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone. nab 53-56 H3 histone pseudogene 16 Homo sapiens 146-149 16800929-5 2006 NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone. nab 53-56 H3 histone pseudogene 16 Homo sapiens 146-149 16800929-5 2006 NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone. nab 53-56 H3 histone pseudogene 16 Homo sapiens 146-149 15498118-4 2004 It is concluded that the NaB effect on cell proliferation/differentiation may be linked to its ability to induce expression of p21 mRNA and inhibit the cyclin D-CDK complexes. nab 25-28 H3 histone pseudogene 16 Homo sapiens 127-130 16343270-11 2006 Treatment with NaB increased the expression of p21 in JeKo-1 and Hbl-2 cells, while in Granta 519 cells no effect was noted. nab 15-18 H3 histone pseudogene 16 Homo sapiens 47-50 14709802-5 2003 Treatment of cells with 1 mM NaB or 1 nM TGF 1 for 4 d decreased cell proliferation with a concomitant increase in the cell cycle protein p21. nab 29-32 H3 histone pseudogene 16 Homo sapiens 138-141 1652685-5 1991 Clonal analysis of this population demonstrated that the increased NAb binding was associated with tumorigenic conversion and ras-p21 expression. nab 67-70 H3 histone pseudogene 16 Homo sapiens 130-133 11668507-3 2001 NaB-mediated p21 might arrest endometrial and ovarian cancer cells at the G0/G1 phase by eliciting pRb unphosphorylation. nab 0-3 H3 histone pseudogene 16 Homo sapiens 13-16 11668507-8 2001 This suggested that NaB had the potential to elicit SLPs through p21-mediated withdrawal from cell cycle progression. nab 20-23 H3 histone pseudogene 16 Homo sapiens 65-68