PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32788915-4 2020 The aim of this study was to investigate the effect of sodium butyrate (NaB) as a histone deacetylase inhibitor (HDACi) on the expression of the HDAC8 gene in the colorectal cancer cell line, and the molecular docking of the LHX1 transcription factor with NaB. nab 72-75 histone deacetylase 8 Homo sapiens 145-150 32788915-9 2020 Based on Real-time-PCR results, the concentration of 150 mM of NaB after 24 hours in HT-29 and HCT-116 cell lines caused a significant reduction in mRNA expression of HDAC8 (P<0.05). nab 63-66 histone deacetylase 8 Homo sapiens 167-172 26876786-9 2016 Further, SAHA and NaB can inhibit the association of HDAC8 and YY1, increase acetylation of residues 170-200 of YY1, then decrease its transcription activities, and finally suppress YY1 induced p53 transcription. nab 18-21 histone deacetylase 8 Homo sapiens 53-58