PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33152341-4	2021	NaB administration inhibited total HDAC activity and enhanced acetylation level of histones specifically in histone H4, accompanying the increase of transcription levels of immediate-early genes (IEGs) (c-fos and Arc) and neurotrophins (BDNF and NT-4) crucial for neuroplasticity in the motor cortex.	nab	0-3	brain derived neurotrophic factor	Mus musculus	237-241	
34890760-8	2022	NaB treatment upregulated the expression of the growth factor-related factors PPARgamma, CREB, and BDNF in the brain tissues of HFD-fed mice.	nab	0-3	brain derived neurotrophic factor	Mus musculus	99-103	
32377164-6	2020	In addition, by acting on the GPR109A receptor, NaB regulates the expression of AD-related genes such as APP, NEP, and BDNF.	nab	48-51	brain derived neurotrophic factor	Mus musculus	119-123	
30145846-8	2018	The combined treatment with NaB + Nico resulted in increased BDNF level and higher PI3K, APE1, and the downstream NF-kappaB activation, which were blocked by pretreatment with their respective inhibitors.	nab	28-31	brain derived neurotrophic factor	Mus musculus	61-65	
26957230-6	2016	However, NaB treatment significantly ameliorated behavioral deficits of the CUMS-induced mice, increased 5-HT concentration, increased BDNF expression, and up-regulated Occludin and zonula occludens-1(ZO-1) protein levels in the hippocampus, which demonstrated that NaB could partially restore CUMS-induced blood-brain barrier (BBB) impairments.	nab	9-12	brain derived neurotrophic factor	Mus musculus	135-139	
26957230-8	2016	In conclusion, these results demonstrated that NaB significantly improved depression-like behaviors in CUMS-induced mice and its antidepressant actions might be related with, at least in part, the increasing brain 5-HT concentration and BDNF expression and restoring BBB impairments.	nab	47-50	brain derived neurotrophic factor	Mus musculus	237-241	
26064905-10	2015	10 mg/kg NaB treatment also remarkably inhibited the apoptosis, decreasing the levels of caspase-3 and Bax and increasing the levels of Bcl-2, p-Akt, and BDNF.	nab	9-12	brain derived neurotrophic factor	Mus musculus	154-158	
26064905-11	2015	This study suggested that NaB exerts neuroprotective effects on cerebral I/R injury by antioxidant, anti-inflammatory, and antiapoptotic properties and BDNF-PI3K/Akt pathway is involved in antiapoptotic effect.	nab	26-29	brain derived neurotrophic factor	Mus musculus	152-156	
32109532-10	2020	Concomitantly, BDNF and TrkB expression, which was decreased by sevoflurane, was also restored by NaB.	nab	98-101	brain derived neurotrophic factor	Mus musculus	15-19	
23615664-5	2013	We demonstrate that the enabling effects of exercise and NaB on subthreshold OLM learning are dependent on hippocampal BDNF upregulation, and are blocked by hippocampal infusion of BDNF short-interfering RNA.	nab	57-60	brain derived neurotrophic factor	Mus musculus	119-123	
23615664-5	2013	We demonstrate that the enabling effects of exercise and NaB on subthreshold OLM learning are dependent on hippocampal BDNF upregulation, and are blocked by hippocampal infusion of BDNF short-interfering RNA.	nab	57-60	brain derived neurotrophic factor	Mus musculus	181-185	
23615664-6	2013	Exercise and NaB increased bdnf transcripts I and IV, and the increases were associated with BDNF promoter acetylation on H4K8 but not H4K12.	nab	13-16	brain derived neurotrophic factor	Mus musculus	27-31	
23615664-6	2013	Exercise and NaB increased bdnf transcripts I and IV, and the increases were associated with BDNF promoter acetylation on H4K8 but not H4K12.	nab	13-16	brain derived neurotrophic factor	Mus musculus	93-97	
23475543-6	2013	Furthermore, activation of cAMP response element binding (CREB) protein, but not NF-kappaB, by NaB, abrogation of NaB-induced expression of neurotrophic factors by siRNA knockdown of CREB and the recruitment of CREB and CREB-binding protein to the BDNF promoter by NaB suggest that NaB exerts its neurotrophic effect through the activation of CREB.	nab	114-117	brain derived neurotrophic factor	Mus musculus	248-252	
34101131-9	2021	NaB significantly decreased the CVS-induced anxiety level by elevating acetyl-H3K9 and BDNF expression.	nab	0-3	brain derived neurotrophic factor	Mus musculus	87-91