PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34896331-10 2022 Notably, NaB activated autophagy pathway through upregulating PGC-1alpha expression. nab 9-12 PPARG coactivator 1 alpha Rattus norvegicus 62-72 34896331-11 2022 More importantly, NaB promoted the levels of histone 3 lysine 9 acetylation (H3K9Ac) and histone 3 lysine 27 acetylation (H3K27Ac) at PGC-1alpha promoter region, indicating that NaB promotes PGC-1alpha expression via histone acetylation modification. nab 18-21 PPARG coactivator 1 alpha Rattus norvegicus 134-144 34896331-11 2022 More importantly, NaB promoted the levels of histone 3 lysine 9 acetylation (H3K9Ac) and histone 3 lysine 27 acetylation (H3K27Ac) at PGC-1alpha promoter region, indicating that NaB promotes PGC-1alpha expression via histone acetylation modification. nab 18-21 PPARG coactivator 1 alpha Rattus norvegicus 191-201 34896331-11 2022 More importantly, NaB promoted the levels of histone 3 lysine 9 acetylation (H3K9Ac) and histone 3 lysine 27 acetylation (H3K27Ac) at PGC-1alpha promoter region, indicating that NaB promotes PGC-1alpha expression via histone acetylation modification. nab 178-181 PPARG coactivator 1 alpha Rattus norvegicus 134-144 34896331-11 2022 More importantly, NaB promoted the levels of histone 3 lysine 9 acetylation (H3K9Ac) and histone 3 lysine 27 acetylation (H3K27Ac) at PGC-1alpha promoter region, indicating that NaB promotes PGC-1alpha expression via histone acetylation modification. nab 178-181 PPARG coactivator 1 alpha Rattus norvegicus 191-201 34896331-12 2022 In conclusion, NaB can protect against rotenone-induced toxicity through activation of the autophagy pathway by upregulating PGC-1alpha expression via epigenetic modification. nab 15-18 PPARG coactivator 1 alpha Rattus norvegicus 125-135 32459091-4 2020 In particular, NaB promoted the activity of mitochondrial antioxidant enzymes and energy metabolism, preserved bone microstructure and calcium homeostasis, and activated bone metabolism, as shown by increased Nrf2/GSK-3beta signaling and the upregulation of PGC-1alpha and TFAM. nab 15-18 PPARG coactivator 1 alpha Rattus norvegicus 258-268