PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35429118-4 2022 NaB inhibited NRF2/NRF2-target genes and blocked NRF2-ARE signaling. nab 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 35429118-4 2022 NaB inhibited NRF2/NRF2-target genes and blocked NRF2-ARE signaling. nab 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 35429118-4 2022 NaB inhibited NRF2/NRF2-target genes and blocked NRF2-ARE signaling. nab 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 49-53 35429118-5 2022 NaB increased NRF2 negative regulator KEAP1 expression through inhibiting its promoter methylation. nab 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 32555166-10 2020 We demonstrated that NaB increased the expression levels of p21 under high cholesterol, contributing to p21/NRF2 (Nuclear factor erythroid 2-related factor 2) colocalization, which leads to NRF2 stabilization. nab 21-24 NFE2 like bZIP transcription factor 2 Homo sapiens 108-112 32555166-10 2020 We demonstrated that NaB increased the expression levels of p21 under high cholesterol, contributing to p21/NRF2 (Nuclear factor erythroid 2-related factor 2) colocalization, which leads to NRF2 stabilization. nab 21-24 NFE2 like bZIP transcription factor 2 Homo sapiens 114-157 32555166-10 2020 We demonstrated that NaB increased the expression levels of p21 under high cholesterol, contributing to p21/NRF2 (Nuclear factor erythroid 2-related factor 2) colocalization, which leads to NRF2 stabilization. nab 21-24 NFE2 like bZIP transcription factor 2 Homo sapiens 190-194 34106394-11 2021 NaB also suppressed the BAX nuclear translocation and modulated Nrf-2, HO-1 and MnSOD expression in neuroblastoma cells. nab 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 64-69 32555166-13 2020 In conclusion, we demonstrated that NaB prevents excessive ROS through NOX2 suppression and SOD1 upregulation by p21/NRF2 pathway, which is critical for inhibiting BACE1-dependent amyloidogenesis in neuronal cells exposed to high cholesterol environment. nab 36-39 NFE2 like bZIP transcription factor 2 Homo sapiens 117-121 23696823-9 2013 Pharmacological studies and siRNA knockdown experiments showed that NaB-mediated AMPK activation induced the phosphorylation and nuclear translocation of Sirtuin 1, leading to the increased assembly of mammalian TOR complex 2 and phosphorylation of AKT at Ser473 and subsequent induction of Nrf2 expression and activation. nab 68-71 NFE2 like bZIP transcription factor 2 Homo sapiens 291-295