PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32056265-6 2020 INS and/or INS+GDP treatments, which markedly increased the insulinemia, increased the p-Akt: total Akt ratio and prevented the increased p-HSLSer552 : total HSL ratio in the retroperitoneal fat of tumor-bearing rats, without changing the INS resistance and increased expression of factor tumor necrosis-alpha (TNF-alpha) in this tissue. Dipeptides 15-18 AKT serine/threonine kinase 1 Rattus norvegicus 89-92 34036924-1 2021 BACKGROUND: A dimeric dipeptide mimetic of the BDNF loop 4, bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106), which activates TrkB, PI3K/AKT, MAPK/ERK and PLC-gamma1 was created at the V.V. Dipeptides 22-31 AKT serine/threonine kinase 1 Rattus norvegicus 156-159 32056265-7 2020 INS and INS+GDP also increased the p-Akt: total Akt ratio, whereas GDP and INS+GDP increased the GLUT4 glucose transporter gene expression, in the gastrocnemius muscle of the tumor-bearing rats. Dipeptides 12-15 AKT serine/threonine kinase 1 Rattus norvegicus 37-40 31201630-1 2019 Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. Dipeptides 37-46 AKT serine/threonine kinase 1 Rattus norvegicus 167-170 31720014-2 2019 A dipeptide mimetic of NGF loop 4, bis(N-succinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2), developed at the Zakusov Research Institute of Pharmacology, has the NGF-like ability to activate TrkA receptors, but unlike NGF, GK-2 activates mainly the PI3K/AKT pathway associated with neuroprotection and has no effect on the MAPK cascade associated with hyperalgesia, the main side effect of NGF. Dipeptides 2-11 AKT serine/threonine kinase 1 Rattus norvegicus 261-264 31024748-0 2019 A Novel Dipeptide NGF Mimetic GK-2 Selectively Activating the PI3K/AKT Signaling Pathway Promotes the Survival of Pancreatic beta-Cells in a Rat Model of Diabetes. Dipeptides 8-17 AKT serine/threonine kinase 1 Rattus norvegicus 67-70