PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25305505-0	2015	Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production.	alisporivir	0-11	peptidylprolyl isomerase A	Homo sapiens	37-49	
24227937-6	2013	Because of antiviral activity, the CypA inhibitors have been tested for the treatment of chronic hepatitis C. Nonimmunosuppressive Cyp inhibitors such as NIM811, SCY-635, and Alisporivir have attracted more interests for appropriating CypA for antiviral chemotherapeutic target on HCV infection.	alisporivir	175-186	peptidylprolyl isomerase A	Homo sapiens	35-39	
24227937-6	2013	Because of antiviral activity, the CypA inhibitors have been tested for the treatment of chronic hepatitis C. Nonimmunosuppressive Cyp inhibitors such as NIM811, SCY-635, and Alisporivir have attracted more interests for appropriating CypA for antiviral chemotherapeutic target on HCV infection.	alisporivir	175-186	peptidylprolyl isomerase A	Homo sapiens	235-239	
22902549-9	2013	Cyp inhibitors such as cyclosporine A (CsA) or non-immunosuppressive derivates such as alisporivir and SCY-635, prevent IRF9-CypA complex formation.	alisporivir	87-98	peptidylprolyl isomerase A	Homo sapiens	125-129	
16199531-2	2005	To address this issue, we sought viruses for CypA independence using Debio-025, a cyclosporine A (CsA) analog that disrupts CypA-capsid interaction.	alisporivir	69-78	peptidylprolyl isomerase A	Homo sapiens	45-49	
16199531-2	2005	To address this issue, we sought viruses for CypA independence using Debio-025, a cyclosporine A (CsA) analog that disrupts CypA-capsid interaction.	alisporivir	69-78	peptidylprolyl isomerase A	Homo sapiens	124-128	
30198892-0	2018	X-ray structure of alisporivir in complex with cyclophilin A at 1.5 A resolution.	alisporivir	19-30	peptidylprolyl isomerase A	Homo sapiens	47-60	
22973029-7	2012	Furthermore, the difference in CyPA dependence between a subgenomic and a full-length replicon of JFH-1 was due, at least in part, to an additional role that CyPA plays in HCV assembly, a conclusion that is supported by experiments with the clinical CPI alisporivir.	alisporivir	254-265	peptidylprolyl isomerase A	Homo sapiens	31-35	
24900335-1	2011	Cyclosporine A (CsA) and its chemical analogues EthVal4Cs, MeVal4Cs, and Me(d-Ala)3EthVal4Cs (Alisporivir) all interact with cyclophilin A (CypA).	alisporivir	94-105	peptidylprolyl isomerase A	Homo sapiens	125-138	
24900335-1	2011	Cyclosporine A (CsA) and its chemical analogues EthVal4Cs, MeVal4Cs, and Me(d-Ala)3EthVal4Cs (Alisporivir) all interact with cyclophilin A (CypA).	alisporivir	94-105	peptidylprolyl isomerase A	Homo sapiens	140-144	
18212100-1	2008	Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity.	alisporivir	0-9	peptidylprolyl isomerase A	Homo sapiens	111-124	
18212100-1	2008	Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity.	alisporivir	0-9	peptidylprolyl isomerase A	Homo sapiens	126-130