PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25120206-0 2014 Correlations of (18)F-fluorothymidine uptake with pathological tumour size, Ki-67 and thymidine kinase 1 expressions in primary and metastatic lymph node colorectal cancer foci. alovudine 22-37 thymidine kinase 1 Homo sapiens 86-104 25003822-0 2014 Phosphorylation status of thymidine kinase 1 following antiproliferative drug treatment mediates 3"-deoxy-3"-[18F]-fluorothymidine cellular retention. alovudine 97-130 thymidine kinase 1 Homo sapiens 26-44 23229746-0 2013 Evaluation of 3"-deoxy-3"-[18F]-fluorothymidine (18F-FLT) kinetics correlated with thymidine kinase-1 expression and cell proliferation in newly diagnosed gliomas. alovudine 14-47 thymidine kinase 1 Homo sapiens 83-101 22995377-2 2012 3"-deoxy-3"-fluorothymidine (FLT), a specific exogenous substrate for TK1, is phosphorylated by TK1 in the presence of a phosphorylating buffer, therefore the conversion of FLT to 3"-deoxy-3"-fluorothymidine monophosphate (FLT-MP) can be measured to assess serum TK1 activity. alovudine 0-27 thymidine kinase 1 Homo sapiens 70-73 22995377-2 2012 3"-deoxy-3"-fluorothymidine (FLT), a specific exogenous substrate for TK1, is phosphorylated by TK1 in the presence of a phosphorylating buffer, therefore the conversion of FLT to 3"-deoxy-3"-fluorothymidine monophosphate (FLT-MP) can be measured to assess serum TK1 activity. alovudine 0-27 thymidine kinase 1 Homo sapiens 96-99 22995377-2 2012 3"-deoxy-3"-fluorothymidine (FLT), a specific exogenous substrate for TK1, is phosphorylated by TK1 in the presence of a phosphorylating buffer, therefore the conversion of FLT to 3"-deoxy-3"-fluorothymidine monophosphate (FLT-MP) can be measured to assess serum TK1 activity. alovudine 0-27 thymidine kinase 1 Homo sapiens 96-99 22995377-2 2012 3"-deoxy-3"-fluorothymidine (FLT), a specific exogenous substrate for TK1, is phosphorylated by TK1 in the presence of a phosphorylating buffer, therefore the conversion of FLT to 3"-deoxy-3"-fluorothymidine monophosphate (FLT-MP) can be measured to assess serum TK1 activity. alovudine 29-32 thymidine kinase 1 Homo sapiens 70-73 22995377-2 2012 3"-deoxy-3"-fluorothymidine (FLT), a specific exogenous substrate for TK1, is phosphorylated by TK1 in the presence of a phosphorylating buffer, therefore the conversion of FLT to 3"-deoxy-3"-fluorothymidine monophosphate (FLT-MP) can be measured to assess serum TK1 activity. alovudine 29-32 thymidine kinase 1 Homo sapiens 96-99 22995377-2 2012 3"-deoxy-3"-fluorothymidine (FLT), a specific exogenous substrate for TK1, is phosphorylated by TK1 in the presence of a phosphorylating buffer, therefore the conversion of FLT to 3"-deoxy-3"-fluorothymidine monophosphate (FLT-MP) can be measured to assess serum TK1 activity. alovudine 29-32 thymidine kinase 1 Homo sapiens 96-99 22020872-0 2012 3"-deoxy-3"-[18F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: a pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response. alovudine 0-32 thymidine kinase 1 Homo sapiens 166-184 22572708-1 2012 Although [(18)F]fluorothymidine positron emission tomography (FLT-PET) permits estimation of tumor thymidine kinase-1 expression, and thus, cell proliferation, high physiological uptake of tracer in liver tissue can limit its utility. alovudine 16-31 thymidine kinase 1 Homo sapiens 99-117 21925976-2 2011 Here, we describe a robust alternative method that monitors proliferating cell thymidine kinase 1 (TK1) activity via LC-MS/MS quantification of 3"-deoxy-3"-fluorothymidine (FLT) and its monophosphate metabolite FLT-MP. alovudine 144-171 thymidine kinase 1 Homo sapiens 79-97 21925976-2 2011 Here, we describe a robust alternative method that monitors proliferating cell thymidine kinase 1 (TK1) activity via LC-MS/MS quantification of 3"-deoxy-3"-fluorothymidine (FLT) and its monophosphate metabolite FLT-MP. alovudine 144-171 thymidine kinase 1 Homo sapiens 99-102 21925976-2 2011 Here, we describe a robust alternative method that monitors proliferating cell thymidine kinase 1 (TK1) activity via LC-MS/MS quantification of 3"-deoxy-3"-fluorothymidine (FLT) and its monophosphate metabolite FLT-MP. alovudine 173-176 thymidine kinase 1 Homo sapiens 79-97 21925976-2 2011 Here, we describe a robust alternative method that monitors proliferating cell thymidine kinase 1 (TK1) activity via LC-MS/MS quantification of 3"-deoxy-3"-fluorothymidine (FLT) and its monophosphate metabolite FLT-MP. alovudine 173-176 thymidine kinase 1 Homo sapiens 99-102 21764789-0 2011 Tumor 3"-deoxy-3"-(18)F-fluorothymidine ((18)F-FLT) uptake by PET correlates with thymidine kinase 1 expression: static and kinetic analysis of (18)F-FLT PET studies in lung tumors. alovudine 24-39 thymidine kinase 1 Homo sapiens 82-100 21764789-1 2011 UNLABELLED: We report the first, to our knowledge, findings describing the relationships between both static and dynamic analysis parameters of 3"-deoxy-3"-(18)F-fluorothymidine ((18)F-FLT) PET and the expression of the proliferation marker Ki-67, and the protein expression and enzymatic activity of thymidine kinase-1 (TK1) in surgically resected lung lesions. alovudine 162-177 thymidine kinase 1 Homo sapiens 301-319 21764789-1 2011 UNLABELLED: We report the first, to our knowledge, findings describing the relationships between both static and dynamic analysis parameters of 3"-deoxy-3"-(18)F-fluorothymidine ((18)F-FLT) PET and the expression of the proliferation marker Ki-67, and the protein expression and enzymatic activity of thymidine kinase-1 (TK1) in surgically resected lung lesions. alovudine 162-177 thymidine kinase 1 Homo sapiens 321-324 20723540-0 2010 Induction of thymidine kinase 1 after 5-fluorouracil as a mechanism for 3"-deoxy-3"-[18F]fluorothymidine flare. alovudine 72-104 thymidine kinase 1 Homo sapiens 13-31 20395329-3 2010 3"-deoxy-3"-(18)F-fluorothymidine ((18)F-FLT) is a PET tracer that is phosphorylated by thymidine kinase 1 (TK-1) and, as such, reflects cellular proliferation. alovudine 0-33 thymidine kinase 1 Homo sapiens 88-106 20395329-3 2010 3"-deoxy-3"-(18)F-fluorothymidine ((18)F-FLT) is a PET tracer that is phosphorylated by thymidine kinase 1 (TK-1) and, as such, reflects cellular proliferation. alovudine 0-33 thymidine kinase 1 Homo sapiens 108-112 20359195-1 2010 Human cytosolic thymidine kinase (hTK1) has proven to be a suitable target for the noninvasive imaging of cancer cell proliferation using radiolabeled thymidine analogues such as [(18)F]3"-fluoro-3"-deoxythymidine ([(18)F]FLT). alovudine 186-213 thymidine kinase 1 Homo sapiens 34-38 18837546-1 2008 Human cytosolic thymidine kinase (hTK1) has proven to be a suitable target for noninvasive imaging of cancer cell proliferation using radiolabeled substrates such as [ (18)F]fluorothymidine ([ (18)F]FLT). alovudine 174-189 thymidine kinase 1 Homo sapiens 34-38 18665170-3 2008 3"-deoxy-3"-[18F]fluorothymidine uptake is dependent on thymidine kinase 1 (TK) activity, but the effects of chemotherapeutic agents are unknown. alovudine 0-32 thymidine kinase 1 Homo sapiens 56-74 18665170-3 2008 3"-deoxy-3"-[18F]fluorothymidine uptake is dependent on thymidine kinase 1 (TK) activity, but the effects of chemotherapeutic agents are unknown. alovudine 0-32 thymidine kinase 1 Homo sapiens 76-78 15093811-1 2004 The use of thymidine (TdR) and thymidine analogs such as 3"-deoxy-3"-fluorothymidine (FLT) as positron emission tomography (PET)-based tracers of tumor proliferation rate is based on the hypothesis that measurement of uptake of these nucleosides, a function primarily of thymidine kinase-1 (TK(1)) activity, provides an accurate measure of cell proliferation in tumors. alovudine 57-84 thymidine kinase 1 Homo sapiens 271-296 11929696-1 2002 The usefulness of radiolabeled 3"-fluoro-3"-deoxythymidine (FLT), a thymidine derivative with affinity to cytoplasmic thymidine kinase 1 (TK1), as a tumor proliferation marker was evaluated using [3H]FLT and 22 cultured tumor cell lines. alovudine 31-58 thymidine kinase 1 Homo sapiens 118-136 11929696-1 2002 The usefulness of radiolabeled 3"-fluoro-3"-deoxythymidine (FLT), a thymidine derivative with affinity to cytoplasmic thymidine kinase 1 (TK1), as a tumor proliferation marker was evaluated using [3H]FLT and 22 cultured tumor cell lines. alovudine 31-58 thymidine kinase 1 Homo sapiens 138-141 11929696-1 2002 The usefulness of radiolabeled 3"-fluoro-3"-deoxythymidine (FLT), a thymidine derivative with affinity to cytoplasmic thymidine kinase 1 (TK1), as a tumor proliferation marker was evaluated using [3H]FLT and 22 cultured tumor cell lines. alovudine 60-63 thymidine kinase 1 Homo sapiens 118-136 11929696-1 2002 The usefulness of radiolabeled 3"-fluoro-3"-deoxythymidine (FLT), a thymidine derivative with affinity to cytoplasmic thymidine kinase 1 (TK1), as a tumor proliferation marker was evaluated using [3H]FLT and 22 cultured tumor cell lines. alovudine 60-63 thymidine kinase 1 Homo sapiens 138-141 28551637-1 2017 The proliferation status of tumor cells can be imaged using [18F]fluorothymidine ([18F]FLT), which is trapped by cell cycle-dependent thymidine kinase 1 (TK1). alovudine 65-80 thymidine kinase 1 Homo sapiens 134-152 28551637-1 2017 The proliferation status of tumor cells can be imaged using [18F]fluorothymidine ([18F]FLT), which is trapped by cell cycle-dependent thymidine kinase 1 (TK1). alovudine 65-80 thymidine kinase 1 Homo sapiens 154-157