PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21803585-1 2011 Previously, we reported potent pentapeptidic BACE1 inhibitors with the hydroxymethylcarbonyl isostere as a substrate transition-state mimic. isostere 93-101 beta-secretase 1 Homo sapiens 45-50