PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24902787-9	2014	Treatment of INS-1 cells with paroxetine (5 and 10 mumol/L) significantly inhibited insulin secretion, decreased the intracellular insulin, 5-HT, Insulin-2 mRNA and Tph-1 mRNA levels.	Paroxetine	30-40	tryptophan hydroxylase 1	Rattus norvegicus	165-170	
28968985-5	2017	Immunohistochemical analyses of TPH1/2 showed less TPH1 and TPH2 expression, specifically TPH2, in the brain, liver and kidney of the depressive rats than in the healthy rats; In addition, the two TPH isoforms, TPH1 and TPH2, had different spatial distributions,the mRNAs of the TPH1/2 genes were significantly decreased and TPH1/2 were highly methylated in the depressive model rat, but treatment with paroxetine ameliorated the expression and methylation of TPH1/2.	Paroxetine	403-413	tryptophan hydroxylase 1	Rattus norvegicus	32-35	
28968985-6	2017	All together, stress was able to inhibit expression of TPH1/2 in brain tissue and decrease concentration of 5-HT, the mechanism maybe involve in increasing the methylation of TPH2 genes promoter; Paroxetine has a role in confronting the effect of stress in depressive rat model.	Paroxetine	196-206	tryptophan hydroxylase 1	Rattus norvegicus	55-61